Keller Lab

Whole-chromosome duplications drive antimicrobial resistance in Aspergillus fumigatus Aneuploidy causes genome plasticity and enables adaptive responses that confer drug resistance in eukaryotes ranging from fungal pathogens to human cancer cells. Aspergillus fumigatus is a soil-reside...

Excited to share our new preprint in collaboration with @kellerlab.bsky.social! We identified unstable aneuploidy in Aspergillus fumigatus and explore how aneuploidy-mediated transcriptional and metabolic changes influence antifungal resistance.

www.biorxiv.org/content/10.1...

Long-term monitoring of a North American cheese cave reveals mechanisms and consequences of fungal adaptation Using a unique longitudinal sampling approach, Louw et al. demonstrate how a cheese-associated Penicillium population has adapted in an artisan cheese production facility in Vermont, USA. Adaptation i...

Long-term monitoring of a North American cheese cave reveals mechanisms and consequences of fungal adaptation

Penicillium solitum over 8 years in a cheese cave => green-to-white shift

@currentbiology.bsky.social from @benwolfe.bsky.social with @kellerlab.bsky.social

www.cell.com/current-biol...

Importantly, we also show the strength of the zebrafish larval model to study virulence factors across fungal species.

Larval zebrafish burn wound infection model reveals conserved innate immune responses against diverse pathogenic fungi | mBio Secondary fungal infections within burn wound injuries are a significant problem that delays wound healing and increases the risk of patient mortality. Currently, little is known about how fungi colon...

New publication with the Huttenlocher Lab! Led by PhD candidate Nayanna Mercado Soto, we used zebrafish to study burn wound infections with Candida albicans & Aspergillus fumigatus, showing the innate immune response is highly conserved across fungal species. #fungi journals.asm.org/doi/10.1128/...