Melissa Mavers, MD, PhD

Welcome to our 2 new lab members--Margaret Bohm and Bibiana Barrios!! Also want to recognize all of Emily Landy's hard work! #NationalPostdocAppreciationWeek
#iNKT #iNKTcells #GVHD #CellTherapy #immunology #GVHDsm #bmtsm @washumedicine.bsky.social @sitemancenter.bsky.social

Deeply grateful to our funding sources for this work, including the St. Baldricks Foundation and the NIH (NHLBI & NCI).

Our comprehensive analysis of human iNKT cells from multiple immunologically relevant hematologic tissues provides critical insights into their transcriptional heterogeneity and an invaluable resource for future research and development of iNKT-based therapies to optimize their safety & efficacy.

We saw 2 transcriptionally distinct CD8+ iNKT cell populations, one naïve/precursor-like & one Th1/17/NK-like, & several distinct CD4+ populations, including a Th1/17/NK-like one. These findings suggest that CD4 & 8 expression (or lack thereof) does not always correlate with functional propensity.

A combined Th1/17 transcriptional signature was detected in some human iNKT cells (verified by co-expression of Tbet & RORgt protein)--similar to human MAIT cells, yet different than mouse iNKT cells. We further uncover unique transcription factor dynamics and identify TEMRA-like iNKT cells.

We analyzed human iNKT cells from several immunologically relevant hematologic tissues & saw 3 main transcriptional signatures: naïve/precursor, transitional, and Th1/17/NK-like, providing new insights into iNKT development & functional potential, with similarities & differences to mouse iNKT cells.

#Immunology #GVHDsm #bmtsm @washumedicine.bsky.social @sitemancenter.bsky.social

Single-cell transcriptomic profiling reveals diversity in human iNKT cells across hematologic tissues Invariant natural killer T (iNKT) cells are evolutionarily conserved innate lymphocytes important for protection against pathogens, malignancies, and …

Our study on human #iNKT cell diversity across hematologic tissues-now out! @cp-cellreports.bsky.social
#iNKTcells: important in immunity & potential #CellTherapy for cancer & #GVHD, so learning their biology is👍
Kudos to @dhollingsworth1996.bsky.social & all!🧵
www.sciencedirect.com/science/arti...

We analyzed human iNKT cells from several immunologically relevant hematologic tissues & saw 3 main transcriptional signatures: naïve/precursor, transitional, and Th1/17/NK-like, providing new insights into iNKT development & functional potential, with similarities & differences to mouse iNKT cells.

#Immunology #GVHDsm #bmtsm @washumedicine.bsky.social @sitemancenter.bsky.social

#Immunology #GVHDsm #bmtsm @washumedicine.bsky.social @sitemancenter.bsky.social

So honored to receive the inaugural Best Abstract/Talk Award at the Consortium for #iNKT Research & Therapy's 1st Meeting! Very thankful to the organizers for an amazing conference! #iNKTcells #GVHD #CellTherapy #Immunology #GVHDsm #bmtsm @washumedicine.bsky.social @sitemancenter.bsky.social

Thanks @stevestonedraws.bsky.social! I love your drawings (and your interest in our work) so much!

This might be the coolest thing I’ve ever seen on Pubmed!

So excited for the 1st meeting of the #CiRT Consortium for #iNKT Research & Therapy in beautiful Prague! Honored to share our work w/ others who love #iNKTcells too & work together to bring iNKT #celltherapy for cancer & #GVHD. #bmtsm #cartcells @sitemancenter.bsky.social @washumedicine.bsky.social

Oh great, thank you, and thanks for taking the time to put this together!

Been looking for something like this, thank you! (Viewers, feel free to add me too.)

This gave me a chuckle I needed this morning!

So excited for #ASH24! Come see Emily Landy’s amazing work on human #iNKTCells biology so we can make better #celltherapy for cancer & fight #GVHD. Sat 12/12 at 5:30 Poster #1159 #iNKT #CART #CARTcells #immunity @ash-hematology.bsky.social @sitemancenter.bsky.social @washumedicine.bsky.social