CFlores-Lab

This was possible to our collaborators & the efforts of @beaguilleng.bsky.social. We are also in debt with the funding agencies making this possible ACIISI-GobCan, @isciiisalud.bsky.social y.social , @cienciagob.bsky.social b.bsky.social , ITER-Cabildo de Tenerife, & @ciberisciii.bsky.social

Genome-wide association studies and rare exonic variant analyses supported the association of HMGCR, previously linked to cholesterol metabolism, evidencing the potential of the pathway as a target for treatments. Check it out!

Genome-wide association study of susceptibility to acute respiratory distress syndrome A common variant near HMGCR was associated with ARDS risk, suggesting a link between cholesterol metabolism and ARDS risk. Validation in independent studies is needed.

We now present a new study completing a genetic screening of sepsis-associated ARDS including patients from five studies and exome sequencing analysis on prioritized regions. www.thelancet.com/journals/ebi...

Sepsis-associated acute respiratory distress syndrome in individuals of European ancestry: a genome-wide association study A common variant within the FLT1 gene is associated with sepsis-associated ARDS. Our findings support a role for the vascular endothelial growth factor signalling pathway in ARDS pathogenesis and iden...

Back in 2020, we showed that variants of the VEGF axis, particularly FLT1 variants, are associated with risk to sepsis-associated ARDS. www.thelancet.com/journals/lan...

Sepsis develops as a systemic severe response to an infection causing organ dysfunction and is associated with a high mortality rate and long-term sequelae among survivors. The lungs are among the organs more frequently affected, causing acute distress syndrome (ARDS).

By now, it would not surprise anyone to understand that there are host genetic variants governing severe infection outcomes.

Want to better understand what interstitial lung diseases are and what do we aim for with the project PRECISION-ILD funded by @isciiisalud.bsky.social involving the participation of many researchers from Spain and abroad? Check the project's webpage: precisionepid.com

Want to better understand what interstitial lung diseases are and what do we aim for with the project PRECISION-ILD funded by @isciiisalud.bsky.social involving the participation of many researchers from Spain and abroad? Check the project's webpage: precisionepid.com