Fraser Aitken

New layer fMRI book chapter on the value of layer-fMRI for understanding psychiatric disorders.

by J Haarsma and P Kok @jhaarsma.bsky.social @peterkok.bsky.social

doi.org/10.1007/7854...

Beautiful paper by the brilliant @jhaarsma.bsky.social exploring how false and veridical percepts converge and diverge. Turns out both share content-specific and confidence signals; and hellohello pre-stimulus alpha... what are you up to with false percepts?

Overview of the simulation strategy and analysis. a) Pial and white matter boundaries surfaces are extracted from anatomical MRI volumes. b) Intermediate equidistant surfaces are generated between the pial and white matter surfaces (labeled as superficial (S) and deep (D) respectively). c) Surfaces are downsampled together, maintaining vertex correspondence across layers. Dipole orientations are constrained using vectors linking corresponding vertices (link vectors). d) The thickness of cortical laminae varies across the cortical depth (70–72), which is evenly sampled by the equidistant source surface layers. e) Each colored line represents the model evidence (relative to the worst model, ΔF) over source layer models, for a signal simulated at a particular layer (the simulated layer is indicated by the line color). The source layer model with the maximal ΔF is indicated by “˄”. f) Result matrix summarizing ΔF across simulated source locations, with peak relative model evidence marked with “˄”. g) Error is calculated from the result matrix as the absolute distance in mm or layers from the simulated source (*) to the peak ΔF (˄). h) Bias is calculated as the relative position of a peak ΔF(˄) to a simulated source (*) in layers or mm.

🚨🚨🚨PREPRINT ALERT🚨🚨🚨
Neural dynamics across cortical layers are key to brain computations - but non-invasively, we’ve been limited to rough "deep vs. superficial" distinctions. What if we told you that it is possible to achieve full (TRUE!) laminar (I, II, III, IV, V, VI) precision with MEG!

Congrats all!

Communication of perceptual predictions from the hippocampus to the deep layers of the parahippocampal cortex High-resolution neuroimaging reveals stimulus-specific predictions sent from hippocampus to the neocortex during perception.

Our study using layer fMRI to study the direction of communication between the hippocampus and cortex during perceptual predictions is finally out in Science Advances! Predicted-but-omitted shapes are represented in CA2/3 and correlate specifically with deep layers of PHC, suggesting feedback. 🧠🟦

Hope it goes well in the new role Joost.

best of luck George

In vivo reconstruction of Duvernoy's postmortem vasculature images

- Fast, high-res imaging: Whole-brain 0.35 mm MRI in <7 min at 7 T
- Vessel-type specific podt-processing: Capturing large leptomeningeal, pial, and intracortical meso-veins

PDF: doi.org/10.1101/2025...

Newcastle United are rolling through the city with their prized possession — the Carabao Cup 🏆

Bruno wont be going anywhere

Tapping into the Rhythms That Lead to Predictions in the Brain André Bastos' work is giving researchers a new window into the brain rhythms that lead to predictive processing.

Tapping into the Rhythms That Lead to Predictions in the Brain
www.cogneurosociety.org/tapping-into...
#neuroscience

Real bound

A detailed theory of thalamic and cortical microcircuits for predictive visual inference A generative vision model offers a detailed theory for cortical columns, thalamus, and computations in cortical circuits.

Happy to have this published …https://www.science.org/doi/10.1126/sciadv.adr6698

Nottingham Forest are only the second side in Premier League history to lose a game by 5+ goals and then follow it up by immediately winning their next game in the competition by 5+ goals.

Who was the first?

at this rate, yes

New layer-fMRI manuscript describing the predictive processing across layers of auditory areas. By
Lonike Faes et al.
biorxiv.org/lookup/doi/1...

This holiday season, take a moment to visit your local bookstore. It’s about more than finding a great book—it’s about supporting the small businesses that keep our communities thriving.

Been great for us but cant have a player with this level of missed games.

Huge game for Eddie. Leicester in league and then Brentford in league cup must win games.