Lionel Le Bourhis

I came here to say this.
I like kurzgesagt, but i was disappointed that they didn't even mention immigration as a partial solution.

L’intervention de Mme Primas a été d’une vacuité intersidérale.

Those Holiday parties were epic. Bet they still are. 😁

Please add me if you can. Thanks

Today was the annual Remind Getaid meeting of French clinical and translational research on Inflammatory Bowel Diseases.
There were great discussion and a vibrant hommage to Nicolas Barnich.

Mature tuft cell phenotypes are sequentially expressed along the intestinal crypt-villus axis following cytokine-induced tuft cell hyperplasia Intestinal tuft cells are epithelial sentinels that trigger host defense upon detection of parasite-derived compounds. While representing interesting targets for immunomodulatory therapies in inflamma...

New work on #tuft cells, rare guardians of our #gut against invaders. How they work is not known. We show that intestinal tuft types 1&2 are sequentially expressed phenotypes during differentiation. And…we can now generate mature immune-related tuft-2’s in #organoids for more 🔬🧫🧬🔥
shorturl.at/EImjA

Hello. Would like to be added. Thanks

would love to be added to the list.
thanks!

We didn’t test because of alloreactivity. But Tcell from CD tend to be more agressive against spheroids from a cell line.

Indeed! Thank you. Will correct that in version 2.0

The Cure is long lasting and still very powerful 40 years later

Would like to be added if possible! Thanks

I would like to be added

Please, have a read and don't hesitate to comment!

Second, this differentiation was more marked in organoids from CD patients.
Third, T cells from CD patients interacted more with organoids than in control conditions and induced increased epithelial cell death. Importantly, this phenotype was observed after multiple passages of the organoids.

First, we show that T cells induce differentiation of epithelial cells towards secretory lineages in control conditions. organoids from ileal had more Paneth cells while colon organoids showed more Goblet cells.

T cell mediated impairment of epithelial integrity in Crohn's disease T lymphocytes play a major role in intestinal homeostasis, with a particular impact on the balance between self-renewal and differentiation of intestinal epithelial cells (IECs). In Crohn's disease (C...

Very proud of this one. Sarah Hamoudi, PhD student in the lab, developed autologous cocultures between mucosal T cells and epithelial organoids from control or from patients with Crohn's disease.
www.biorxiv.org/content/10.1...

T cell mediated impairment of epithelial integrity in Crohn's disease https://www.biorxiv.org/content/10.1101/2024.11.12.621219v1 T lymphocytes play a major role in intestinal homeostasis, with a particular impact on the balance b

T cell mediated impairment of epithelial integrity in Crohn's disease https://www.biorxiv.org/content/10.1101/2024.11.12.621219v1