Aydogan Lab

Cancer Research Laboratory | Trumanlab | UNC Charlotte | United States The Trumanlab at UNC Charlotte incorporates protein biochemistry, molecular biology, proteomics, systems biology, bacterial and yeast genetics as well as cell culture technologies to identify novel an...

We are looking for talented graduate students to join our group for Fall 2026 studying the role and regulation of Hsp70 PTMs! If you are interested please check out www.trumanlab.org

To all lipid-curious cell biologists: check out this comprehensive overview of lipid-based methods by @gerryhammond.bsky.social and colleagues in @jcb.org — a school of Babel fish for #lipidtime:

rupress.org/jcb/article/...

Spatial barcoding reveals reaction radii and contact-dependent mechanism of proximity labeling - Nature Chemical Biology A DNA nanoruler platform enables precise measurement of the labeling radii of TurboID and APEX2, uncovering their contact-dependent mechanisms. These findings redefine the enzymology of proximity labe...

Proximity labeling users: check out this study by @zhixingchen2.bsky.social and Peng Zou, which establishes how much contact-dependence vs. diffusion is responsible for biotinylation — tl;dr TurboID has a much smaller effective radius! www.nature.com/articles/s41... 1/2

Modern biology research is biased towards investigating genes that are widely conserved and present in humans. What about genes that ARE widely conserved but NOT present in humans? Can genes missing from humans tell us something about what makes our biology different from that of other animals? 1/8

Interesting analysis, Jeremy! Do you see them being exclusively metabolism related genes, or do you find structural or otherwise housekeeping stuff? I feel that this is quite expected in metabolism since it's highly attuned to the feeding habits and extracellular milieu.

Bad antibodies are such a huge problem. It’s not just the money wasted on buying them. It’s the amount of time spent trying to validate them.

A still picture from the 1961 documentary on zebrafish development by J.V. Durden showing a 1 dpf zebrafish embryo.

I was today years old when I learned that there is a superb (freely available) documentary from 1961 on early zebrafish development by J.V. Durden. collection.nfb.ca/film/embryon... (1/2)

#Mastodon, the Command Center for Large-Scale Lineage-Tracing Microscopy Datasets, is finally heading for publication (well, let's see). To #cite or not to cite shall no longer be the question 🙃, because the #preprint. Software is available in every #Fiji near you.

www.biorxiv.org/content/10.6...

I was just wondering about this the other day!! A timely print!

Didn’t we already know that for along time?? See this classic McIntosh piece from 2001 (Figure 2C)

www.pnas.org/doi/10.1073/...

The final night at #CellBio25! Ended the day with wonderful talks at the centrosomes in cell division session - the field is strong 💪 💪 Sponsored by @jcellsci.bsky.social
& @nikonmicroanz.bsky.social!

Thanks to the amazing organizers Tim Megraw, Renata Basto, @lablerit.bsky.social & Chad Pearson!

Oxidative phosphorylation complexes contain subunits encoded by both the nuclear and mitochondrial genomes. How do cells coordinate the synthesis and assembly of these complexes at the inner membrane? We teamed up with Martin Ott (@mitolab.bsky.social) to address this in two recent papers.

Rapid compensatory evolution within a multiprotein complex preserves telomere integrity Intragenomic conflict with selfish genetic elements spurs adaptive changes in subunits of essential multiprotein complexes. Whether and how these adaptive changes disrupt interactions within such comp...

How to keep in step when your (protein) partner speeds up…

Here we investigated the adaptive remodeling of a protein-protein interaction surface essential for telomere protection.

Congrats to whole team!

www.science.org/doi/10.1126/...

Summer Undergraduate Research Experience | HHMI The Cech Fellows Program is a paid, nine-week summer research experience empowering the next generation of scientific leaders.

@hhmi.org Summer Undergraduate Research Experience - #CechFellows named in honor of Prof Tom Cech
Deadline to apply: 12/22/2025
Spend 9 weeks in a paid, mentored biomedical research experience in an HHMI lab. See you next summer!!!
www.hhmi.org/programs/cec...

SAVE THE DATE! Stoked to organize the 2026 Santa Cruz Developmental Biology Meeting with @rashmi-priya.bsky.social, @lowelab.bsky.social, and Shelbi Russell. Come learn about Biomedicine, Biomechanics, and the Biosphere, August 24-28, 2026. Registration dates, etc., coming soon! Please RT

Dylan, such a stunning video! Do you know if a portion of these cardiomyocytes are binucleated like you'd see postnatally in heart formation?

DNA REPAIR/GENOME STABILITY CONFERENCES

🧬 List of 2026 DNA repair and genome stability conferences, now updated. Please let me know if there is anything missing!
docs.google.com/spreadsheets...

Adipogenin promotes the development of lipid droplets by binding a dodecameric seipin complex The microprotein adipogenin (Adig) is predominantly expressed in adipose tissues. Here, we found that Adig interacts with seipin to form a stable, rigid complex. We present the structure of the seipin...

New paper in Science identifying adipogenin as a critical seipin regulator in LD biogenesis. So glad our lab could help a little in this monumental study. Congrats to all authors!

www.science.org/doi/10.1126/...

Happy Halloween! 🎃 Continuing my tradition of Nobel-prize-winning discoveries, this year's costume is Ubx!!!
It honors Edward B. Lewis, Christiane Nüsslein-Volhard, & Eric Wieschaus's work on the genetics of development 🧬🪰
(Please clap for the accuracy of those wing veins on *both* pairs of wings.)

Regulation of cell proliferation by a novel feedback system on Cdk function The proliferation of eukaryotic cells is regulated by a complex network of regulatory systems that promotes efficient cell cycle progression and ensures proper responses to the environment. Despite th...

Minimal CDK continues delivering 💥

www.biorxiv.org/content/10.1...

Still so much to learn!

So exciting!!! I hope all goes well Monica!

📣 We are moving to Barcelona to join the amazing @crg.eu and explore how centrosomes & cilia work, evolve & respond to the environment. We are looking for
PhD students www.crg.eu/en/content/t...
Postdocs gimm.pt/jobs/postdoc...
Other calls to open, also for an experienced lab manager.
Get in touch!

love these on the subway

Reaffirming the value of model organisms in training scientific minds - Nature Cell Biology As biomedical research prioritizes human models and translational promise, classic model organisms are increasingly dismissed. Here we argue that they have a lasting value, both in enabling discovery and in cultivating scientific thinking, by training researchers in systems reasoning, integrative thinking and independent inquiry.

PREACH!

www.nature.com/articles/s41...

Senior Director - Scientific Officer Primary Work Address: 4000 Jones Bridge Road, Chevy Chase, MD, 20815 Current HHMI Employees, click here to apply via your Workday account. The Howard Hughes Medical Institute (HHMI) advances the disco...

Great Job - Great Colleagues - Great Science👍
Help us pick the next generation of @hhmi.org Investigators, Freeman Hrabowski Scholars, Hanna Gray Fellows, Gilliam Fellows
Relocation to DC is required, perfect for academic PIs looking for their next chapter
hhmi.wd1.myworkdayjobs.com/External/job...

🥳🥳 Massive congrats, Ishmail!!

I’m extremely honored to be a recipient of the NIH Director’s Pioneer Award!

Sperm sequencing reveals extensive positive selection in the male germline - Nature A combination of whole-genome NanoSeq with deep whole-exome and targeted NanoSeq is used to accurately characterize mutation rates and genes under positive selection in sperm cells.

Now published! Our paper on:
(1) Accurate sequencing of sperm at scale
(2) Positive selection of spermatogenesis driver mutations across the exome
(3) Offspring disease risks from male reproductive aging
[1/n]
www.nature.com/articles/s41...

Looks very useful indeed! Thank you for sharing!