@schefflab.bsky.social
The goal of our research is to investigate whether therapy targeted to peripheral neurons in the cancer microenvironment can alleviate pain and slow tumor progression. https://schefflab.pitt.edu/ #cancerneuroscience #research
Cancer #pain isn't just a symptom, it can influence survival. Our new commentary in @cp-cancercell.bsky.social explores the idea that choosing the right analgesic could improve tumor immunity. Thanks to my co-authors for their support with this piece! #cancerneuroscience
www.cell.com/cancer-cell/...
www.biorxiv.org/content/10.1... New data from us on Botox-A effects on human DRG neurons, including some really surprising effects on DRG transcriptome. All of this work was led by Katherin Gabriel, and was a great collaboration with our friends at AbbVie.
25.06.2025 13:26 — 👍 9 🔁 1 💬 1 📌 0
#REVIEW 🚨
Amit et al. outline the reciprocal interactions among neurons, immune cells and tumour cells that regulate peripheral antitumour immune responses and discuss how these mechanisms could be leveraged to enhance immunotherapy.
📖 ⬇️
Thank to #RushtoCrush for a great weekend raising funds for #cancer #research!
21.05.2025 15:26 — 👍 0 🔁 0 💬 0 📌 0Thanks to @pcpr-pittpain.bsky.social and other sponsors for this event!
painday.pitt.edu
Graduate student Andre Martel Matos stands next to his poster entitled: Sympathetic Neurotransmission Contributes to Oral Cancer-Induced Spontaneous Pain.
Hannah White presents her poster entitled: Sensory Innervation in the Tumor Microenvironment of Breast Cancer.
Certificate awarding Andre Martel Matos with Best Poster Presentation in Pre-Clinical Research (predoctoral) category.
🎉Congratulations to @andremartel.bsky.social for winning BEST POSTER at yesterday's #painday, held at the University of Pittsburgh @cnup.bsky.social! Thanks to Hannah and @nehamokhasi.bsky.social for their excellent contributions.
08.05.2025 15:41 — 👍 4 🔁 0 💬 1 📌 0
Graduate student Andre Martel Matos presents his poster entitled "Sympathetic Neurotransmission Contributes to Oral Cancer-Induced Spontaneous Pain" to several conference attendees
Dr Nicole Scheff presents research poster entitled "Temporal characterization of radiation-induced oral pain using a mouse model" to two conference attendees
Thanks to @usasp.bsky.social for a great conference! Dr Scheff discussed reverse translation in #cancerpain and presented a poster detailing new work on radiation-induced pain and oral mucositis. @andremartel.bsky.social presented updates on his project on sympathetics and cancer pain. #research
06.05.2025 18:53 — 👍 4 🔁 0 💬 0 📌 0
@andremartel.bsky.social and I had an awesome time teaching at the inaugural Cold Spring Harbor Laboratory 2025 Methods in Cancer Neuroscience course this week! #cshl #cancerneuroscience. Wish we could have stayed but had to be home for the Stand Up For Science Event! @standupforscience.bsky.social
07.03.2025 15:35 — 👍 4 🔁 0 💬 0 📌 0
The Gulf Coast Consortia invites you to register for their Feb. 21, #Pain2025 workshop featuring Rita Allen Scholars, Kara Marshall, Baylor College of Medicine, and Katelyn Sadler, Univ. of Texas, Dallas. The event will occur via Zoom webinar on Feb. 21, from 1-2 pm (CST).
10.02.2025 14:58 — 👍 4 🔁 1 💬 1 📌 0Elegant paper from the Gereau lab examining intrinsic adaptive plasticity in mouse and human sensory neurons rupress.org/jgp/article/...
17.12.2024 17:44 — 👍 13 🔁 3 💬 0 📌 0
Proposed cycle between nociceptive input and autonomic output in cancer. Sensitization of nociceptive sensory neurons by the tumor microenvironment leads to propagation of orthodromic signaling towards the central nervous system (CNS).
📢New publication out: Sensory Neurotransmission and Pain in Solid Tumor Progression! This review article by first author @andremartel.bsky.social details recent work on the bidirectional relationship between sensory neurons and #cancer cells.
authors.elsevier.com/sd/article/S...
#neurobiology
🎉Excited to share that our application, “Breast Cancer Control of Neural Invasion Modulates Immunosurveillance” has been funded by The Magee Women’s Cancer Research and Education Funding Committee. We are grateful for the support to explore this new direction!
#breastcancer #neuroscience #immunology
What is the best time of the month to treat breast cancer? #Nature
"Breast Cancer: Menstrual cycle may affect chemotherapy sensitivity"
Open Access
www.nature.com/articles/s41...
📢Check out our new publication, Morphine treatment restricts response to immunotherapy in oral squamous cell carcinoma, out now in the Journal for ImmunoTherapy of Cancer! This article presents urgent work with implications for improving ICI therapy responses. jitc.bmj.com/content/12/1...
21.11.2024 18:33 — 👍 3 🔁 0 💬 0 📌 0
The application deadline is on December 6th: meetings.cshl.edu/courses.aspx...
Whether you're a neuroscientist or a cancer biologist, this is the training you’ve been waiting for!
#cancerneuroscience
Don't miss out on the chance to register for Neural Influence on Cancer and snag a $200 discount if you sign up by December 3, 11:59 pm MST. Secure your spot now at hubs.la/Q02YNzHH0. #KSNeuroCancer25 #CancerNeuroscience
20.11.2024 16:05 — 👍 5 🔁 3 💬 0 📌 0
