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Synthesis Workshop

@synthesisworkshop.bsky.social

An open access content creation initiative in chemistry, featuring video podcast episodes, courses, problem sets, virtual research posters, and more. Homepage: synthesis-workshop.com

146 Followers  |  25 Following  |  42 Posts  |  Joined: 23.11.2024  |  2.097

Latest posts by synthesisworkshop.bsky.social on Bluesky

Ligand Design for Light-driven Nickel Catalysis with Dr. Lucia Anghileri
YouTube video by Synthesis Workshop Videos Ligand Design for Light-driven Nickel Catalysis with Dr. Lucia Anghileri

Join us this week on Synthesis Workshop as Dr. Lucia Anghileri shares her work on ligand design for light-driven nickel catalysis!!

Link: youtu.be/-4ggoK4ACUk

Key paper:
J. Am. Chem. Soc. 2025, 147, 13169.
doi.org/10.1021/jacs...

Thanks to Dr. Alicia Wagner for hosting!

31.01.2026 15:09 β€” πŸ‘ 2    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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Tune in this week as Dr. Terrence-Thang Nguyen shares his work on asymmetric C-H functionalization and the synthesis of (-)-dragocin D!!

Link: youtu.be/Gh1qxy7Z7K0

@jacs.acspublications.org 2025, 147, 31, 28098–28106.
doi.org/10.1021/jacs...

Thanks to Kathleen for hosting!

24.01.2026 20:36 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

Another fantastic Chemical Science paper being highlighted by @synthesisworkshop.bsky.social!

Check out the video and make sure to read the paper at pubs.rsc.org/en/content/a...!

23.01.2026 12:11 β€” πŸ‘ 3    πŸ” 2    πŸ’¬ 0    πŸ“Œ 0
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Once you've seen the episode, head over to synthesis-workshop.com/problem-sets to check out the accompanying problem and solution set!!

17.01.2026 20:29 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
Bio-inspired Total Synthesis of Daphnepapytone A with Joan Pereira
YouTube video by Synthesis Workshop Videos Bio-inspired Total Synthesis of Daphnepapytone A with Joan Pereira

Tune in this week as Joan Pereira shares his work on a bio-inspired total synthesis of daphnepapytone A!!

Link: youtu.be/rhhpewmsRBc

Big thanks to Reem for hosting and editing!

17.01.2026 20:29 β€” πŸ‘ 3    πŸ” 1    πŸ’¬ 2    πŸ“Œ 1
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Tune in for our first Research Spotlight of 2026, where Dr. Ruocheng Sang shares his work on a radical approach to the boron-to-copper transmetalation problem!!

Link: youtu.be/EVtEZwUSrbU

@jacs.acspublications.org doi.org/10.1021/jacs...

03.01.2026 14:45 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
Redox-powered Autonomous Directional C–C Bond Rotation Under Enzyme Control with Jordan Berreur
YouTube video by Synthesis Workshop Videos Redox-powered Autonomous Directional C–C Bond Rotation Under Enzyme Control with Jordan Berreur

Join us this week as Jordan Berreur shares his work on redox-powered autonomous directional C–C bond rotation under enzyme control, published this year in @nature.com!! Thanks to Xingfeng for hosting!

Link: youtu.be/2InU6iFBYFQ

Nature 2025, 644, 96–101.
doi.org/10.1038/s415...

21.12.2025 18:06 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
Introduction to Prebiotic Chemistry: Prebiotic Peptide Synthesis with Dr. Benji Thoma
YouTube video by Synthesis Workshop Videos Introduction to Prebiotic Chemistry: Prebiotic Peptide Synthesis with Dr. Benji Thoma

Tune in today as Dr. Benji Thoma returns for the second installment in our mini-course on prebiotic chemistry, this time focusing on prebiotic peptide synthesis!!

Link: youtu.be/BDuyOmrTsqI

Also check out the first installment on nucleic acid synthesis! youtu.be/Mi6ybPFtt7w

13.12.2025 15:17 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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Cyclic Bifunctional Reagents Enabling a Strain-Release-Driven Formal [3 + 2] Cycloaddition of 2H-Azirines by Cascade Energy Transfer The energy transfer (EnT)-catalyzed ring opening and further decarboxylation of isoxazole-5(4H)-ones enables the in situ generation of strained 2H-azirines. Subsequent selective C(sp2)–C(sp3) bond cle...

Curious to hear the story behind this paper?

doi.org/10.1021/jacs...

Tune in today on Synthesis Workshop to hear from Dr. Alessia Petti about this exciting advance: youtu.be/optSQ_YY5jE

@jacs.acspublications.org

06.12.2025 15:12 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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Join us today as Dr. Mikus Purins shares his work recently published in @science.org on bridging the pyridine-pyridazine synthesis gap using skeletal editing!

Link: youtu.be/k2nOfYnNk6U

Key paper:
Science 2025, 389(6757), 295-298.
www.science.org/doi/10.1126/...

Thanks to Karim for hosting!!

29.11.2025 20:37 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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πŸ”¬ You know a young innovator in #organicsynthesis? Great!
Nominate them for the Thieme–IUPAC Prize 2026!
πŸŽ–οΈ €5,000 prize
πŸ“© Deadline: Dec 12, 2025
πŸ“€ Send to: marcus.white@thieme.de
More: thieme.de/en/thieme-ch...
@synlettjournal.bsky.social @synthesisworkshop.bsky.social @orgsynth.bsky.social

25.11.2025 11:53 β€” πŸ‘ 1    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0

Do make sure to check out this Synthesis Workshop video to discover how aluminyl anions can have enhanced reactivity which enables selective C-H activation! πŸ§ͺ #ChemSky

20.10.2025 10:55 β€” πŸ‘ 3    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0
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Is it possible to form a stereogenic carbon with four heteroatom substituents? Would it be configurationally stable? Tune in today to find out in a brand new episode with Olivier Viudes, hosted by Alicia Wagner!

Link: youtu.be/-pyvGu56Suo

@jacs.acspublications.org 2025, 147, 21121.

08.11.2025 15:52 β€” πŸ‘ 2    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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We have a brand new Research Spotlight episode, as well as a Problem Set and Solution set dropping today!! Tune in to learn about diastereoselective umpolung cyclization reactions with Dr. Giulia Iannelli!

Link: youtu.be/uyKZgUbB5Fk
Link to our problem sets: synthesis-workshop.com/problem-sets.

01.11.2025 14:34 β€” πŸ‘ 2    πŸ” 1    πŸ’¬ 0    πŸ“Œ 1
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Tune in today for a brand new Research Spotlight episode with Charlotte O’Donnell, focusing on her recent total synthesis of aspidospermidine!

Link: youtu.be/lzDv8cJRTyQ

18.10.2025 15:34 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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Tune in today to hear Dr. Fabian Kallmeier explain how to enhance the nucleophilicity of aluminum anions, which he recently published in @chemicalscience.rsc.org, in a brand new Research Spotlight episode!

Link: youtu.be/6XBF6Iqi3vE

Key paper:
doi.org/10.1039/D5SC...

11.10.2025 14:03 β€” πŸ‘ 4    πŸ” 1    πŸ’¬ 0    πŸ“Œ 1
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Join us today to learn about controlled anionic polymerizations with Paige Jacky, focusing on her recently published work in Nature Chemistry!!

Link: youtu.be/6XD7dBUByyQ

Nat Chem. 2025, 17, 1076-1082.
doi.org/10.1038/s415...

06.09.2025 13:48 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 2
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This talk also comes with a great hands on tutorial activity designed by the speaker - check it out at synthesis-workshop.com/courses!

23.08.2025 13:47 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
A Crash Course on Cheminformatics with Dr. Fu Kit (Frederick) Sheong
YouTube video by Synthesis Workshop Videos A Crash Course on Cheminformatics with Dr. Fu Kit (Frederick) Sheong

Join. us today as we kick off a brand new course, "Cheminformatics and Computational Chemistry", with an excellent introductory talk on cheminformatics by Dr. Fu Kit Sheong!! If you're interested in contributing to this course, reach out!

Link: youtu.be/Hx8kVIsRlO4

23.08.2025 13:47 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0
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Reimagining Advanced Chemistry Education: A Community-based Approach to Course Design for Modern Learners Chemistry education at the graduate level and beyond faces the formidable challenge of a boundless and constantly expanding frontier of knowledge on many fronts. While modern learners have an increasi...

Today after years of work and a tight collaboration between >40 chemists in academia and industry, we are thrilled to share the story of how our Advanced Organic Chemistry course and other courses were created in the Journal of Chemical Education!

Link: doi.org/10.1021/acs....

15.08.2025 14:17 β€” πŸ‘ 5    πŸ” 2    πŸ’¬ 0    πŸ“Œ 1
Preview
Synthesis Workshop Videos Synthesis Workshop is a channel dedicated to presenting advances in synthetic organic chemistry in an open-access format with concise explanations and clear visuals. Created by Matthew Horwitz, Ph.D.

The @synthesisworkshop.bsky.social channel covers a whole host of publications and cutting edge research in the area of organic chemistry.

Highly recommended if you are in this area and would like to keep up to date with the field:
www.youtube.com/@SynthesisWo...

11.08.2025 08:06 β€” πŸ‘ 4    πŸ” 1    πŸ’¬ 1    πŸ“Œ 0
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Join us today to hear from Ann-Sophie Paschke and Stefanie Schiele from the @morandilab.bsky.social about their work on C-to-N atom swapping reactions!! Thanks to Karim for hosting and editing!

Link: youtu.be/D513hX1gOTg

@chemicalscience.rsc.org
doi.org/10.1039/D5SC...

09.08.2025 13:38 β€” πŸ‘ 6    πŸ” 2    πŸ’¬ 0    πŸ“Œ 1
Non-enzymatic Methylcyclization of Alkenes with Immanuel Plangger
YouTube video by Synthesis Workshop Videos Non-enzymatic Methylcyclization of Alkenes with Immanuel Plangger

Join us this week on Synthesis Workshop as Immanuel Plangger shares his work on the development of a non-enzymatic methylcyclization reaction!! Thanks to Fabrizio Politano for hosting and editing!

Link: youtu.be/fnFfw9T5DTM

Key paper:
Nat. Chem. 2025, 17, 904–910.
doi.org/10.1038/s415...

19.07.2025 22:15 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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Very excited to announce that our recent review has been featured on the cover of Synthesis!!

If you haven't had a chance to check it out yet, here is a link to the review: doi.org/10.1055/a-26...

18.07.2025 14:31 β€” πŸ‘ 3    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0
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Join us this week as Jonathan Gruhin @alexanian-lab.bsky.social shares his work on the homologation of carboxylic acids! Thanks to Alicia Wagner for hosting and editing!!

Link: youtu.be/hbrrRyy0zfU

Key paper:
J. Am. Chem. Soc. 2024, 146, 48, 32919–32924
doi.org/10.1021/jacs...

12.07.2025 19:08 β€” πŸ‘ 2    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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Dive into chiral #DrugDevelopment πŸ’Š This review by Álvarez-Calero & Horwitz @synthesisworkshop.bsky.social highlights efficient, scalable #API synthesis for new drug substances. Discover how asymmetric synthesis drives #pharma innovation via diverse case studies 🧬

πŸ‘‰ buff.ly/ganycgH

02.07.2025 07:01 β€” πŸ‘ 1    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0
Concise Synthesis of Isosteroidal Alkaloids with Michael Zott and Daniel Zuschlag
YouTube video by Synthesis Workshop Videos Concise Synthesis of Isosteroidal Alkaloids with Michael Zott and Daniel Zuschlag

Join us today as Michael Zott and Daniel Zuschlag share their work with Prof. Dirk Trauner on the synthesis of isosteroidal alkaloids!!

youtu.be/Be-vVFLuGzE

Key reference: J. Am. Chem. Soc. 2025, 147, 3010-3016. doi.org/10.1021/jacs...

21.06.2025 14:39 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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Today Γ–mer TaşpΔ±nar joins us to share his work from the Clayden group on asymmetric intramolecular arylation reactions in a virtual research poster!!

Check out the full paper, published under a month ago in Angewandte Chemie here: doi.org/10.1002/anie...

04.06.2025 19:42 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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This is just one example of the problems you'll find in our latest problem set on covalent and noncovalent organocatalysis!! Check out the full set at synthesis-workshop.com in the Problem Sets or Courses section (see the Asymmetric Organocatalysis course).

26.04.2025 20:42 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
Introduction to Asymmetric Organocatalysis: Non-covalent Organocatalysis
YouTube video by Synthesis Workshop Videos Introduction to Asymmetric Organocatalysis: Non-covalent Organocatalysis

Check out the latest installment in our Asymmetric Organocatalysis course!!

Link: youtu.be/pwtS9YWxldI

Once you're done, head over to synthesis-workshop.com and check out the corresponding problem and solution set! You can find it either in the Problem Sets or Courses section.

26.04.2025 20:40 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

@synthesisworkshop is following 20 prominent accounts