apreston243.bsky.social

Two putative Enterococcus faecalis fabG genes do not encode β-ketoacyl-acyl carrier protein reductases Enterococcus faecalis encodes three putative Escherichia coli β-ketoacyl-acyl carrier protein (ACP) reductases (FabG). The fabG1 gene is located within the operon that encodes most of the fatty acid s...

New paper alert! Enterococcus faecalis FabG1 is the only β-ketoacyl-acyl carrier protein (ACP) reductase, even though it encodes two other homologues. @microbiologysociety.org www.microbiologyresearch.org/content/jour...

Increase in lipid portion of Phycomyces blakesleeanus biomass induced by vanadate uptake and accumulation Fungi are ubiquitous micro-organisms involved in various environmental processes, with a particularly important role in the transformation of metals and minerals, bioremediation and biomining. Filamen...

New paper alert. Vanadate sequestration by Phycomyces blakesleeanus is accompanied by an increase in cellular lipid content. @microbiologysociety.org www.microbiologyresearch.org/content/jour...

The EMBL PhD programme is open until 13th October (entry ~Sep 2026):
www.embl.org/about/info/e...

We have three positions in microbial genomics at EMBL-EBI, including one in my group. Please do apply, or if you know anyone that would be interested pass on to them

The interaction between IL-17 and gut microbiota contributes to cholestatic liver disease in children The pathogenesis of cholestatic liver disease (CLD) is unknown, but the influence of gut microbiota and inflammation cannot be ignored. In this study, we attempted to provide theoretical insights for ...

New paper alert! Changes to gut microbiome profiles associate with inflammatory markers in children with cholestatic liver disease. Is dysbiosis driving the pathology? @microbiologysociety.org www.microbiologyresearch.org/content/jour...

Common food preservatives induce an oxidative stress response in Salmonella enterica serovar Typhimurium Despite their frequent use, the mechanisms of action of common food preservatives are poorly understood. As there is a drive to develop alternative preservatives, understanding the mechanisms of actio...

New paper alert! Another good read from @webberma.bsky.social. Different food preservatives induce similar responses in Salmonella typhimurium, including oxidative stress responses. @microbiologysociety.org www.microbiologyresearch.org/content/jour...

Cyclic-di-GMP signalling mutants drive ecological succession and self-generated diversity in experimentally evolved biofilms of Pseudomonas aeruginosa Biofilms represent a discrete form of microbial life which are physiologically distinct from free-living planktonic cells. The altered phenotypic manifestations of the biofilm may also elicit lifestyl...

New paper alert! Serial selection for hyper-biofilm production identifies c-di-GMP as central to genetic control and phenotypic dynamics. @microbiologysociety.org @webberma.bsky.social www.microbiologyresearch.org/content/jour...

Investigating pathogenicity in zoonotic Streptococcus suis at University of Cambridge on FindAPhD.com PhD Project - Investigating pathogenicity in zoonotic Streptococcus suis at University of Cambridge, listed on FindAPhD.com

www.findaphd.com/phds/project...

Microbial Primer: Biosurfactants – the ABCs of microbial surface-active metabolites Microbial surfactants (biosurfactants) are low-molecular-weight amphiphilic secondary metabolites synthesized by a wide range of micro-organisms, including bacteria, yeasts and fungi. These compounds ...

New Primer alert! And now with the correct link, apologies @dezieleric.bsky.social! Microbial Primer on the essentials of biosurfactants. @microbiologysociety.org www.microbiologyresearch.org/content/jour...

I think I'd prefer a rejection in seconds compared to one in months from people who clearly haven't read it.

Role of AprA and pyocyanin from Pseudomonas aeruginosa on Staphylococcus aureus tolerance to silver The opportunistic pathogens Staphylococcus aureus and Pseudomonas aeruginosa are often found together causing persistent infections where they exhibit complex interactions that affect their virulence ...

New paper alert! Complex interactions between Pseudomona aeruginosa and Staph aureus involved in tolerance to silver of Staph. @microbiologysociety.org www.microbiologyresearch.org/content/jour...

Assistant Professor (Research and Education) in Bacterial Genomics at University of Birmingham Apply now for the Assistant Professor (Research and Education) in Bacterial Genomics role on jobs.ac.uk - the leading job board for higher education jobs. View details.

We have a position for an Assist Prof in Microbial Genomics in our School of III.

Hod Joan Geoghegan will be happy to field questions if you are interested. No specific area of microbial genomics preferred so please do consider it

www.jobs.ac.uk/job/DOO184/a...

Enterococcus faecalis requires unsaturated fatty acids to overcome toxicity of environmental saturated fatty acids Enterococcus faecalis synthesizes phospholipids from either de novo synthesized or exogenous fatty acids. However, environmental saturated fatty acids are toxic to E. faecalis. The mechanism of toxici...

New paper alert! Nice insight into the basis for the toxicity of environmental saturated fatty acids towards Enterococcus faecalis. @microbiologysociety.org www.microbiologyresearch.org/content/jour...

Phosphate sensing by PhoPR regulates the cytotoxicity of Staphylococcus aureus Staphylococcus aureus has evolved a complex regulatory network to coordinate expression of virulence factors, including cytolytic toxins, with host environmental signals. Central to this network are t...

New paper alert! Novel insight into regulation of Staph aureus toxicity by phosphate via PhoPR, including a role for the unphosphorylated response regulator. @microbiologysociety.org @masseylab.bsky.social www.microbiologyresearch.org/content/jour...

Fantastic PhD project available (I'm biased obviously) with me and the wonderful Stefano Pagliara at Exeter and @jodymmason.bsky.social at Bath. Bioinformatics, metabolic modelling, single cell imaging and new antibiotics. Who could want more? Apply now! gw4biomed.ac.uk/bacterial-hu...

Fluconazole resistance and CDR1 expression in Candida albicans mediated by the hyperactive Tac1-5 transcriptional activator requires Tlo proteins Candida albicans is an opportunistic fungal pathogen associated with superficial and systemic infections in humans. Azole antifungal resistance in C. albicans is of clinical concern, and both oral and...

New paper alert! Selective TLO gene families are required for expression of Tac-1 mediated fluconazole resistance in Candida albicans. Towards understanding drug resistance in this important pathogen. @microbiologysociety.org @gazmoran.bsky.social www.microbiologyresearch.org/content/jour...

Fantastic PhD project available (I'm biased obviously) with me and the wonderful @PagliaraExeter and @JodyMMason. Bioinformatics, metabolic modelling, single cell imaging and new antibiotics. Who could want more? Apply now! gw4biomed.ac.uk/bacterial-hu...

Assessing the effect of temperature on Rhodococcus metabolite production Rare actinomycetes are increasingly recognised as a valuable yet underexplored source of bioactive compounds with significant biomedical potential. While it is well established that bacteria have evol...

New paper alert. Insight into metabolic shifts in response to temperature in marine strains of Rhodococcus. Implications for mining the biochemistry of rare Actinomycetes. @microbiologysociety.org @kateduncan.bsky.social www.microbiologyresearch.org/content/jour...

Type VI secretion system activity at lethal antibiotic concentrations leads to overestimation of weapon potency Competition assays are a mainstay of modern microbiology, offering a simple and cost-effective means to quantify microbe–microbe interactions in vitro. Here, we demonstrate a key weakness of this meth...

New paper alert! Toxins can skew the results of competition assays, fascinating short communication from @prokaryota.bsky.social and @willpjsmith.bsky.social. @microbiologysociety.org www.microbiologyresearch.org/content/jour...

Bacteriophage resistance evolution in a honey bee pathogen Honey bee (Apis mellifera) larvae are susceptible to the bacterial pathogen Paenibacillus larvae, which causes severe damage to bee colonies. Antibiotic treatment requires veterinary supervision in th...

New paper alert! Resistance to phage in Paenibacillus larvae comes at a cost. Important consideration for developing phage therapy to tackle foul brood. @microbiologysociety.org www.microbiologyresearch.org/content/jour...

Genome-wide mapping of cAMP receptor protein binding in enteroaggregative Escherichia coli reveals targeting of virulence-associated genes Bacterial pathogens employ a diverse array of virulence factors to colonize and subsequently elicit disease in their host. These factors are often subject to extensive regulation at the transcriptiona...

New paper alert! CRP is co-opted to regulate expression of virulence genes in enteroaggregative E. coli, linking virulence state to metabolism. @microbiologysociety.org www.microbiologyresearch.org/content/jour...

The combined effects of tick defensin persulcatusin with conventional antibiotics and antimicrobial proteins/peptides against Staphylococcus aureus Persulcatusin (IP) is a tick defensin isolated from Ixodes persulcatus and is composed of 38 aa (molecular weight of 4,200). IP exhibits potent antimicrobial activity against Staphylococcus aureus, in...

New paper alert! A tick defensin, persulcatsuin, augments antibiotic effect against Staph aureus. @microbiologysociety.org www.microbiologyresearch.org/content/jour...

Engineering the TCA cycle regulator GarA to increase erythromycin production in Saccharopolyspora erythraea Actinobacteria are important for industrial production of antibiotics, fine chemicals and food and a source of new compounds for drug discovery. Their central metabolism is regulated by a conserved pr...

New paper alert! Engineered GarA increases erythromycin production from Saccharopolyspora erythraea. Metabolic engineering for antibiotic production. @microbiologysociety.org www.microbiologyresearch.org/content/jour...

Storage stability of non-encapsulated pneumococci in saliva is dependent on null-capsule clade, with strains carrying aliC and aliD showing a competitive disadvantage during culture enrichment Non-encapsulated Streptococcus pneumoniae (NESp) represent up to 19% of circulating pneumococci and exhibit high rates of genetic exchange and antimicrobial resistance. Saliva is increasingly used as ...

New paper alert! In depth characterisation of non-encapsulated pneumococci in saliva: stability, detection and recovery. Important findings for using saliva samples for carriage studies. @microbiologysociety.org @annewyllie.bsky.social www.microbiologyresearch.org/content/jour...

KpSC-ID: a multiplex real-time PCR assay for the simultaneous detection of the Klebsiella pneumoniae species complex and specific identification of Klebsiella pneumoniae, Klebsiella quasipneumoniae an... The Klebsiella pneumoniae species complex (KpSC) comprises five closely related bacterial species, namely Klebsiella pneumoniae, Klebsiella quasipneumoniae, Klebsiella variicola, Klebsiella quasivarii...

New paper alert! A real time PCR assay to detect and distinguish Klebsiella pneumonia, quasipneumoniae and variicola. @microbiologysociety.org @sylvainbrisse.bsky.social www.microbiologyresearch.org/content/jour...

Pectobacterium atrosepticum SCRI1043 flagella mediate adherence to potato plants indirectly through motility Flagella are widely distributed appendages in bacteria with well-characterized functions in motility and chemotaxis. They also interact directly with hosts and, due to their ubiquity, are potent immun...

New paper alert! Flagella mediated adherence of Pectobacterium atrosepticum to potato plants requires flagella motility. @microbiologysociety.org @nicholden.bsky.social www.microbiologyresearch.org/content/jour...

Microbial Primer: agr-mediated quorum sensing in Gram-positive pathogens Gram-positive bacteria commonly employ autoinducing peptide (AIP) signal molecules to co-ordinate gene expression at the population level. This primer provides a basic overview of agr-dependent quorum...

New paper alert! Microbial Primer on agr-mediated quorum sensing in Gram-positive pathogens, from the absolute authority on the subject, Paul Williams. @microbiologysociety.org www.microbiologyresearch.org/content/jour...

Fab postdoc job opportunity!

Improved efficiency of two-step amplicon PCR using an acoustic liquid handler The improvement in next-generation sequencing technologies has reduced the costs of sequencing significantly. However, library preparation costs for amplicon sequencing have remained largely unchanged...

New paper alert! Bringing acoustic liquid handling to two-step amplicon PCR: greater efficiency permits greater throughput. @microbiologysociety.org @barneygeddes.bsky.social www.microbiologyresearch.org/content/jour...

Prevalence of mutations associated with tolerance to chlorhexidine and other cationic biocides among Proteus mirabilis clinical isolates Proteus mirabilis is a frequent cause of catheter-associated urinary tract infection and often exhibits high tolerance to chlorhexidine (CHD), a biocide used widely in healthcare settings. We previous...

New paper alert! Insights into tolerance to biocides among Proteus mirabilis isolates. @microbiologysociety.org @gingermicrobe.bsky.social @vickyb-micro.bsky.social www.microbiologyresearch.org/content/jour...

Use of bioaerosol stakeholder mapping and engagement for the development of future strategic collaborations: a UK perspective Stakeholder mapping is a process that involves identifying, characterizing and visualizing the connections between stakeholders. It is important to understand the main influencers and those with an in...

New paper alert! Approaches to stakeholder mapping as demonstrated for the bioaerosol field. @microbiologysociety.org www.microbiologyresearch.org/content/jour...