Valérie Borde

AI-generated MLH1 small binder improves prime editing efficiency A compact, AI-generated suppressor of DNA mismatch repair can enhance prime editing in vivo and in vitro and can be integrated into a variety of prime editing architectures.

Now online! AI-generated MLH1 small binder improves prime editing efficiency

RPA directly stimulates Mer3/HFM1 helicase processivity to ensure normal crossover formation in meiosis Meiotic crossover formation is critical for generating viable gametes and enhancing genetic diversity. The helicase Mer3 (HFM1 in humans) is a highly conserved factor essential for promoting crossover...

www.biorxiv.org/content/10.1...

Organizational principles governing assembly and activation of the meiosis-specific Red1-Hop1-Mek1 complex In mitosis, sister chromatids are preferred repair templates for homologous recombination, whereas in meiosis interhomolog-based repair is promoted. How this switch, which is a defining event in sexua...

Revised version of our original Red1-Hop1-Mek1 story, together with @jweir.bsky.social lab now online @biorxivpreprint.bsky.social

Check it out: www.biorxiv.org/content/10.1...

We are hiring!
We are looking for a motivated and enthusiastic postdoc to study mammalian DSB repair using innovative genomic approaches.
Our lab is at the Curie Institute in Paris and offers vibrant scientific environnement and cutting edge platforms.
Please repost or apply here:
lnkd.in/eJ9q3QrR

We’re happy to present a new preprint from the lab, where we identify new mechanisms that drive the recruitment of Mre11 to recombination sites during meiosis. Work led by star student Priyanka Priyadarshini with help from colleagues and funded by the ERC and FNRS.

www.biorxiv.org/content/10.1...

Great work!

Register now for the 7th German-French DNA Repair Meeting, which will take place at the Campus Pierre et Marie Curie of Sorbonne University in Paris, France, from 5–7 November 2025. premc.org/dnarepair202...

A three year postdoctoral position is available in my group, investigating plant centromere structure, function and evolution @camplantsci.bsky.social
www.jobs.cam.ac.uk/job/51488/

Please see our latest paper on the role of EXO1 in meiosis: "EXO1 promotes the meiotic MLH1-MLH3 endonuclease through conserved interactions with MLH1, MSH4 and DNA". Congratulations to both first authors, Megha Roy and Aurore Sanchez and thanks to all our collaborators!

#JobOffer

💼 Ingénieur d’étude H/F en biologie moléculaire
📍 Equipe Prioleau
📅 1e septembre 2025
🔗 emploi.cnrs.fr/Offres/CDD/U...

Candidatez avant le 19 mai 2025

The Genome Integrity Webinar Series continues on Tuesday, May 6th at 5PM (Rome) / 11AM (New York) with an exciting discussion on DNA damage response and repair @kajastelab.bsky.social
Join via Zoom: uniroma1.zoom.us/j/95149984403

We have a complete program !

meiosis.cornell.edu/mayosis2025/...

The #Mayosis25 seminar series will open with a tribute to Scott Hawley by @jeffsekelsky.bsky.social.

Congrats to all the selected speakers and we look forward to hearing about your fantastic science !

#Meiosis4ever

A must for all DNA repair aficionados!

Egmond DNA Repair Meeting → April 19–24, 2026 🇳🇱
✔️ Confirmed top speakers
✔️ Ample opportunities for talks & posters

Don’t miss it: dnarepairmeeting-egmond2026.com

Check out our review on DNA end resection! With Raphael Ceccaldi, www.nature.com/articles/s41...

!! Postdoc position available to study homologous recombination in live cells through advanced microscopy analyses in a collaboration between our lab and Angela Taddei's lab, both at @institutcurie.bsky.social in Paris.
Apply to : job-ref-ib8q3lnnxn@emploi.beetween.com

📣 Last days to register to the "Physics meet Genome" summer school in beautiful Cargèse, Corsica, June 2nd to 6th 2025. Discover the full program and register by March 8th here: iesc-inscriptions.fr

training.institut-curie.org/courses/geno...

Reconstitution of SPO11-dependent double-strand break formation - Nature Reconstitution of recombinantly expressed SPO11–TOP6BL complex recapitulates its DNA cleavage function and together with structural modelling and biochemical experiments, provides insights into the re...

Also see two accompanying papers by the labs of Scott Keeney and Ming-Han Tong reporting similar findings, focusing on the SPO11-TOP6BL complex.
www.nature.com/articles/s41...
www.nature.com/articles/s41...

And here is a nice News&views by Mendez Diaz and Corbett.
www.nature.com/articles/d41...

Elvan Böke, Felicity Jones, Francesca Cole and Ofer Rog

Hear hear, our 4 keynote speakers! #MAYosis

May 7th: Elvan Böke @crg.eu
May 14th: Felicity Jones @unigroningen.bsky.social
May 21st : Ofer Rog @theroglab.bsky.social @utah.edu
May 28th: Francesca Cole @francescacole.bsky.social @mdanderson.bsky.social

meiosis.cornell.edu/mayosis2025/...

🧵⬇️

PRDM9 drives the location and rapid evolution of recombination hotspots in salmonid fish PRDM9 is a DNA-binding protein that helps determine the location of recombination hotspots in many mammals. This study of several species of salmonid fish reveals that PRDM9 function is conserved acro...

PRDM9 drives the location and rapid evolution of recombination hotspots in salmonid fish
journals.plos.org/plosbiology/... interesting findings on PRDM9 polymorphism and hotspot erosion

We have a research laboratory technician post available in my group - the role will support plant work, and molecular biology, associated with our research on centromeres.
www.jobs.cam.ac.uk/job/47342/

Happy new year everyone!

We are please to announce the return of MAYosis in 2025!

Every Wednesday in May at 4pm CET, come hear the latest #meiosis4ever stories!

Abstract sub deadline: March 8 (end of day wherever you are)

meiosis.cornell.edu/mayosis2025/

Please RT. Join the sixth edition of our Training Unit @institut_curie
international course on Genome Instability & Human Disease open to master students, PhDs and researchers! Amazing program. Registration dead line 2nd March 2025 at training.institut-curie.org/courses/geno...

📣 Registration for the 20th course on epigenetics is now open! Explore gene regulation, diseases, and innovations with Alumni now leading the field worldwide. 🌍 This special anniversary edition features a dedicated program, discover it now: training.institut-curie.org/courses/epig...

Meiosis: Exploring diversity to discover the fundamentals Meiosis is an essential cell division for sexual reproduction and fertility across eukaryotes. It involves a series of tightly regulated processes, including entry into meiosis, pairing of homologs, …

Registration now open for the 2025 EMBO workshop on Meiosis! June 22-26, 2025, Engelberg, Switzerland.
Deadline for abstract submissions and registration is Feb 15th, 2025. Lots of speaker slots will be selected from abstracts, so apply now! meetings.embo.org/event/25-mei...

Woo hoo 👍👍👍

Meiosis: Exploring diversity to discover the fundamentals Meiosis is an essential cell division for sexual reproduction and fertility across eukaryotes. It involves a series of tightly regulated processes, including entry into meiosis, pairing of homologs, …

Official website for EMBO meiosis 2025 is live now! Looking forward to seeing you in Switzerland next June! #meiosis4eva

meetings.embo.org/event/25-mei...

Experimental results showing DNA break formation by purified SPO11 protein. Above is an image of an electrophoresis gel, below is a graph showing quantification of the DNA cleaving activity

Hi Bluesky. For my first post, I'd like to advertise the latest preprint from my lab, describing at long last our reconstitution of SPO11-dependent double-strand break formation from purified recombinant proteins. Outstanding work from PhD student Zhi (Zack) Zheng.