Diorge Souza

So happy to see this come together! Huge congratulations to my friend @javierespadas.bsky.social and everyone involved. Amazing job!

Javier has done beautiful work (following on from the study he did with Diorge Souza), showing how Asgard Escrt-III likely cut membranes. The answer: with Hofund.

Fantastic work from Javier @javierespadas.bsky.social in collaboration with @buzzbaum.bsky.social and @kaksonen.bsky.social labs, thank you Chris Toret, thank you Diorge @diorgeps.bsky.social!

Molecular basis for cellular compartmentalization by an ancient membrane fission mechanism The emergence of cell compartmentalization depends on membrane fission to create the endomembrane compartments. In eukaryotes, membrane fission is commonly executed by ESCRT-III, a protein complex con...

New preprint from the lab!!🎉
We show that Asgard archaea ESCRT-III proteins can trigger membrane fission and reveal its molecular mechanism, offering clues to how these cells may have built internal compartments. But do these organisms even have these compartments?
www.biorxiv.org/content/10.1...

Extremely happy to see our work finally out!🎉 Great collaboration between @rouxlab.bsky.social @buzzbaum.bsky.social labs and a real pleasure to work and share co-first authorship with incredible scientists and friends @diorgeps.bsky.social @sami-c.bsky.social. Big thanks to the rest of the authors!

Evolution, structure and membrane remodelling function of the ESCRT-III superfamily in eukaryotes and their closest relatives Asgard archaea. The two subfamilies, B-type and A-type, have distinct structural properties to perform sequential steps of the membrane remodelling pathway.

New research on ancient Asgard archaeal ESCRT-III proteins reveals evolutionary secrets of membrane remodelling.
Diorge Souza, Javier Espadas and Sami Chaaban, investigated the ESCRT-III proteins with Buzz Baum and Aurelien Roux.
Read more: www2.mrc-lmb.cam.ac.uk/asgard-archa...
#LMBResearch (1/2)

ESCRT-III is an ancient complex, present in Archaea, with only two proteins and all membrane remodelling functions. Great work by @javierespadas.bsky.social, @diorgeps.bsky.social, @sami-c.bsky.social, thanks to the @buzzbaum.bsky.social lab! Drawing by Julie Polge.
www.science.org/doi/10.1126/...

Thanks Harry!

Great Oriol! Congrats!

Adding a shout out to @tweethinking.bsky.social and @emoody.bsky.social! Thanks again to the amazing phylogenetics team! And our unique @mrclmb.bsky.social @cellbiol-mrclmb.bsky.social

Also had the pleasure of collaborating with the great Edmund Moody, Tom Williams, Tomoyuki Hatano and @sporemohan.bsky.social! Please check out the original preprint thread on the other 👎 platform x.com/diorge_souza...

The highlight of this project was the collaboration between @buzzbaum.bsky.social and @rouxlab.bsky.social labs, especially working with my incredible friends @javierespadas.bsky.social and @sami-c.bsky.social ! You both rock! 🤜🤛🍻💪

Asgard archaea reveal the conserved principles of ESCRT-III membrane remodeling Asgard archaea have two ESCRT-III subunits with the conserved traits that drive stepwise membrane remodeling in eukaryotes.

Happy to share our paper’s final version on the evolution, structure, and membrane binding / remodeling of Asgard ESCRT-III proteins! And my first 🦋 post! www.science.org/doi/10.1126/...