Joshua Tran

Mum's anti-chemotherapy views influenced Paloma Shemirani's death Paloma Shemirani died after refusing chemotherapy despite a diagnosis of non-Hodgkin lymphoma.

I had non-Hodgkin lymphoma more than 20 years ago. Thankfully I chose chemo over coffee enemas www.bbc.co.uk/news/article...

Molecular basis for the regulation of membrane proteins through preferential lipid solvation - Nature Chemical Biology Static protein structures can capture the association of lipids, but it is unclear whether the association is due to lipids acting as long-lived ligands or the solvation of preferred lipids around the protein. A computational-experimental framework has now shown that for the protein CLC-ec1, it is the change in lipid solvation energies that drives dimerization, with preferred lipids around the protein modulating this driving force.

Are the lipids associated with static protein structures there as long-lived ligands or an effect of preferential solvation? This computational-experimental framework shows the way! #lipidtime #compchem

www.nature.com/articles/s41...

ICYMI: This collection aims to improve the reliability and #reproducibility of studies produced by and for the cell biology community. Further articles in this series are planned and will be added to this collection when they are published. 👉 rupress.org/jcb/collecti...

Now published in @natcomms.nature.com! 🥳

👉 rdcu.be/eATn3

We developed image analysis tools to capture the nematic orientation field of 3D tissue surfaces. Tested on epithelial aggregates, zebrafish hearts, myoblasts on spheres & micro-vessels, we combined soft matter physics with exp. biology.

Indeed! And they’re hard at work 🤩

Good day doing CryoEM and escaping from the heatwave ❄️

Tubulin autoregulation tunes microtubule dynamics to support multicellular architecture and viability Alpha- and beta-tubulin heterodimers dynamically assemble into microtubules, key cytoskeletal elements involved in intracellular trafficking, cell adhesion and division. The availability of free tubul...

🔎New preprint!
We reveal a physiological role for tubulin autoregulation, fine-tuning microtubule dynamics and preserving 3D cellular architecture.
Big thanks to @ivanagasic.bsky.social and team!
Link below for all #cytoskeleton & #spheroid enthusiasts👇(1/5)
www.biorxiv.org/content/10.1...

I am so proud of @jezcarlton.bsky.social . What a magnificent inaugural lecture, many congratulations Professor Carlton!

Frontiers | Dictyosteliumdiscoideum–Mycobacterium marinum infection model: a powerful high-throughput screening platform for anti-infective compounds Tuberculosis is among the world’s deadliest diseases, causing approximately 2 million deaths annually. The urgent need for new antitubercular drugs has been ...

Check our latest methods chapter on how to use Dictyostelium–Mycobacterium marinum as a high-throughput screening platform for anti-infective compounds 👇

www.frontiersin.org/journals/mic...

@nabilhanna3.bsky.social

It was a great pleasure to host @lizmillercu.bsky.social here in Geneva on behalf of the PhD Association!

Phenomenal science. Engaging discussions. And plenty of laughs along the way. What more can you ask for?

Thanks, Liz, for such an insightful and fun visit!

What a fantastic ESCRT meeting, the field is going strong and full of exciting science. Many thanks to @rouxlab.bsky.social @cellarchlab.com @jujumathieu.bsky.social @magromayor.bsky.social @majarad.bsky.social for organising such a a great event

#YeastNomenclature reminder: Protein Name Format

#Yeast proteins are referred to by the relevant gene symbol, non-italic, initial letter uppercase and with the suffix ‘p’ (for example, Ade5p). The suffix can be omitted if the word 'protein' is appended (for example, the Ade5 protein).

Localization of WDS proteins and fimbrin in three fungal species.

How do cells switch on the actin assembly at endocytic sites? How can this on-switch evolve? Check out our new preprint!
www.biorxiv.org/content/10.1...

Justin Krish Williams, Randy Schekman et al. @ucberkeleyofficial.bsky.social show that human cells shed extracellular vesicles in order to repair their membranes. rupress.org/jcb/article/...

#EVs #Exosomes

Congratulations! 🤩

🤩 Last week I successfully defended my PhD!
It was such a special day, made even better by having friends, family, and colleagues there with me. Thanks for all the support and kind words!
Huge thanks to my jury members for the thoughtful feedback and conversations.

@soldatilab.bsky.social

What a conference! It was such a great pleasure to share my research & discuss with amazing cell biologists from all parts of the world at #CellBio2024 . I am inspired by the community & grateful for all the amazing interactions. Looking forward to next time!

@ascbiology.bsky.social

Don’t miss out on TODAY’S session, “Surfing the Surface: Navigating the waves of Membrane Dynamics” at the @ascbiology.bsky.social EMBO #CellBio2024 ! Join us for fascinating talks in Room 30C at 8h45.

#CellBio24

It was a great pleasure to present my work at the In Vitro Organelles Subgroup at #CellBio2024 ! Many thanks to the organizers and everyone who came!

I have my poster, B163, on Tuesday, the 17th at 11h15, to discuss more about membrane bending!

@ascbiology.bsky.social
@rouxlab.bsky.social

I am pleased to be sharing my work in the @rouxlab.bsky.social at ASCB & EMBO Cell Bio 2024!

If you’re interested in membrane bending, crowding, curvature and of course the ESCRT machinery, pass by my talk on Saturday, Dec. 14th and/or my poster on Tuesday, Dec. 17th!

#CellBio2024

🚨 For all membrane dynamics and trafficking enthusiasts attending ASCB|EMBO #CellBio2024!

I will be chairing the session “Surfing the Surface: Navigating the Waves of Membrane Dynamics” on Tuesday, Dec. 17 at 08h45 in Room 30C.

Come join for these amazing talks!

Hi all! 👋 I’m Oriol, PhD student at
@rouxlab.bsky.social , studying how forces impact stem cell behavior and development. Excited to connect and discuss science!!

#Biophysics #StemCells #DevelopmentalBiology

Great talk by Roberto Zoncu from @ucberkeleyofficial.bsky.social on lysosomal integrity and repair hosted by @rouxlab.bsky.social ! I had the pleasure of taking MCB 100B with Roberto during my studies and it was so nice to see the phenomenal research being done!

Hey everyone! Just joined Bluesky! 👋
I’m a postdoc at @rouxlab.bsky.social, working with minimal reconstituted in vitro systems to study the mechanical properties of membranes and how they undergo remodeling.
Expect posts mostly about science, with some curiosity and fun sprinkled in. Let’s connect!

YouTube video by HHMI's Janelia Research Campus Eric Betzig: "Confessions of a Frustrated Optical Microscopist."

Impressive lecture on ( #super-resolution ) #microscopy by Nobel laureate Eric Betzig in Janelia earlier this year. His arguments and data are unbeatable, but also unusual, and his clear point of view is really refreshing.
www.youtube.com/watch?v=OhCV...

Imagine a method capable of obtaining precise quantitative 3D information about a structure or molecular distribution from 2D sections in just a few minutes with only 200 simple counts. This almost magical method - ‘stereology’ - exists and is surprisingly underused. doi.org/10.1002/aja....

Honored to be the recipient of the GSV Prize 2024 for my thesis on +TIP phase separation in the Aumeier lab at the University of Geneva ☺️

First post on BlueSky! Looking forward to sharing and discussing exciting science and more!

Just wanted to share some yeast electron microscopy I’ve done recently :) more science and cool images on the way!