High-resolution microscopy of a mesenchymal cancer cell that has been killed by inactivating the CDS2 gene. Prior to cell death, tiny lipid droplets accumulated, which are still visible as cyan-colored dots, visualized using fluorescence microscopy. The DNA of the dead cancer cells (magenta) is dispersed throughout the surrounding area.
Processed image by Tim Arnoldus, Gemma Driessen and Marjolein Mertz. Legend: magenta = DNA from dead cancer, cyan = lipid droplets
In a new Nature Genetics paper our researchers identified a synthetic lethal interaction in 50% of cancers. Tumors lacking CDS1 depend entirely on CDS2. Blocking CDS2 kills cancer cells while sparing healthy tissue ➡️ www.nki.nl/news-events/...
07.07.2025 09:29 — 👍 8 🔁 1 💬 0 📌 0
Society Melanoma Research Congress
The SMR 2025 Annual Congress (Amsterdam Oct 25-28) covers basic, preclinical & translational melanoma research of international top investigators. It is a very enjoyable conference with top faculty and now improved with ample opportunity for young investigators to network. Join us! smrcongress.org
04.07.2025 12:23 — 👍 8 🔁 5 💬 1 📌 4
https://www.nature.com/articles/s41588-025-02221-2
Major congratulations to my PhD student Tim Arnoldus @nkinl.bsky.social @oncodeinstitute.bsky.social on publishing his exciting discovery today in Nature Genetics! 🎉
By computational mining Tim found a synthetic lethal target that may impact future treatment of half of all cancers.👏
t.co/cQdeYQinsX
04.07.2025 09:48 — 👍 2 🔁 0 💬 0 📌 0
Congrats to Sofía Ibáñez Molero @NKI_nl and
@oncodeinstitute for excellently defending her PhD thesis, on functional interactions between cancer and the immune system, with several interesting papers already published and under review. Great work Sofía and best of luck with your postdoc!
24.01.2025 10:56 — 👍 12 🔁 0 💬 0 📌 0
NKI PhD program 2025 | Cancer Biology | Netherlands Cancer Institute
We are looking for outstanding candidates who want to become our new generation of ambitious PhD students, and join our lively international research community.
📢 Applications for the NKI PhD program now open till Feb 28. Several exciting positions available, including one in my lab on discovering new biology and therapeutic opportunities of a population of enriched tumor-reactive T cells we recently identified.
www.nki.nl/careers-stud...
14.01.2025 11:39 — 👍 3 🔁 1 💬 0 📌 0
More knowledge about immunotherapy, advanced diagnostics, and reducing overtreatment. Thanks to financial support from KWF Dutch Cancer Society, 13 research teams from the Netherlands Cancer Institute are launching new projects ➡️ www.nki.nl/news-events/...
13.12.2024 13:59 — 👍 21 🔁 3 💬 0 📌 0
📢 Applications for the NKI PhD program open from Jan 1 - Feb 28. Join our international research community in Amsterdam, working in cancer biology, AI research & life sciences with leading scientists and top facilities #PhD #CancerResearch More info: bit.ly/3O4bOjq
29.11.2024 08:36 — 👍 26 🔁 16 💬 0 📌 6
Nature Genetics is a monthly journal publishing high impact research in genetics and genomics. Part of @natureportfolio.bsky.social
Repost/like=interesting/relevant, not necessarily endorsement.
Cancer Research UK Career Development Fellow at the Wellcome Sanger Institute - gene editing - drug resistance - cancer
Professor and Chair, cancer biologist. I care about science, equity and cooking. Opinions (lots of them) my own.
Accelerating Cancer Immunotherapy Research. A free weekly digest of the latest findings in #cancer #immunotherapy. We spotlight promising research and attend major meetings. We also make cool images :)
Research group leader @ the 'JaJa' lab on Telomere & Genome Integrity at the Netherlands Cancer Institute @nkinl
Bluesky account for the journal Nature Reviews Immunology https://www.nature.com/nri/ Skyquakes from the editors.
Cancer biologist interested in metabolism and signaling, hopeless optimist and coffee addict. 🏳️🌈
T cell Immunologist, with a passion for RNA biology and translation control, working at Sanquin Blood Supply, Amsterdam
Oncode Institute investigator
Medical Oncologist
Netherlands Cancer Institute
Cell Therapy
Prof of Med Onc #Sarcoma #AYA cancer #RareCancers @Netherlands Cancer Institute; ErasmusMC;
President @EORTC Brussels;
Chairman Dutch AYA cancer network #MedSky #OncSky #SARCsky #AYACSM
Computational & Genomics Lab studying 3D genome function and dynamics @ Netherlands Cancer Institute
Cancer Evolution and Genome Instability Lab Francis Crick Institute. Views my own
Immunologist. T cell exhaustion, immunotherapy, Immune Health.
Cancer Immunometabolism - Professor - Director, Tumor Microenvironment Center - CoFounder, Novasenta - EiC, WILEY Immunology
Prof @ucsf/immunox, co-founder Solvingfor.org, partner Founderyinnovations.com, Immunologist,Immunotherapy pioneer,believer in the power of curiosity,striving to make sense of complicated things, typically enthusiastic.
Husband to Pam Sharma. Immunologist. Nobel Laureate.
Professor of Immunology /Cancer Research UK Senior Fellow @MRC_LMCB @UCL | Lymphoid tissue biology #immunity #cancer | #SciArt | @CRUKresearch
Publishing the best of biotech science and business. Find us on Twitter, Facebook & Instagram. Part of @natureportfolio.nature.com.
Director of Children's Research Institute at UT Southwestern (@cri_utsw.bsky.social) & Howard Hughes Medical Institute Investigator. My lab studies stem cells & cancer. I sit at a computer, grateful that I can "do" science. Views are mine. 🇨🇦🇺🇸
Breast Oncologist and translational researcher @nki, Immunotherapy and immune cell lover, Mother, 🍀🌿
