Aaron Wilber

Direction-selective laterodorsal thalamic nucleus encodes optic flow and turning in spatial navigation Vision is crucial for effective navigation. Li et al. reveal that the dorsolateral nucleus, a higher-order thalamic area linking visual and navigational networks, encodes direction of optic flow and t...

Direction-selective laterodorsal thalamic nucleus encodes optic flow and turning in spatial navigation: Neuron www.cell.com/neuron/fullt...

An optical brain-machine interface reveals a causal role of posterior parietal cortex in goal-directed navigation Relating neural circuitry to behavior is challenging due to closed loop interactions between neural activity, actions, and sensations. Sorrell et al. present evidence for a causal role of mouse PPC in...

An optical brain-machine interface reveals a causal role of posterior parietal cortex in goal-directed navigation: Cell Reports www.cell.com/cell-reports...

32. OREXIN 1 RECEPTOR ANTAGONISM EXACERBATES SLEEP DEFICITS AND REDUCES ANXIETY IN A TAU TRANSGENIC MOUSE MODEL OF ALZHEIMER'S DISEASE - The American Journal of Geriatric Psychiatry www.ajgponline.org/article/S106...

Glymphatic dysfunction in Alzheimer’s disease: A critical appraisal Thirteen years after the initial publication defining the glymphatic system, we critically reappraise the role of its dysfunction in Alzheimer’s disease (AD). Our understanding of glymphatic function ...

Glymphatic dysfunction in Alzheimer’s disease: A critical appraisal | Science www.science.org/doi/10.1126/...

Lemborexant ameliorates tau-mediated sleep loss and neurodegeneration in males in a mouse model of tauopathy - Nature Neuroscience Parhizkar et al. show that lemborexant, an orexin receptor antagonist, protects against neurodegeneration in male tau transgenic mice by preventing tau protein build-up and inflammation, highlighting ...

Lemborexant, a dual orexin receptor antagonist, ameliorates tau-mediated sleep loss and neurodegeneration in males in a mouse model of tauopathy

www.nature.com/articles/s41...

All I want for Christmas is a wireless device that continuously measures features of glymphatic function in humans - nice work Applied Cognition & colleagues; This could be really useful in #Parkinsons research
www.nature.com/articles/s41...

Sleep architecture and dementia risk in adults: An analysis of 5 cohorts from the Sleep and Dementia Consortium url:https://academic.oup.com/sleep/article/doi/10.1093/sleep/zsaf129/8133870

Projection-specific circuits of retrosplenial cortex with differential contributions to spatial cognition - Molecular Psychiatry Molecular Psychiatry - Projection-specific circuits of retrosplenial cortex with differential contributions to spatial cognition

Awesome pub looking at the unique role of AD- and M2-projecting RSC circuits from Xiaoxiao Lin et al.
#neuroskyence
www.nature.com/articles/s41...

A Hippocampal–Parietal Network for Reference Frame Coordination Navigating space and forming memories based on spatial experience are crucial for survival, including storing memories in an allocentric (map-like) framework and conversion into egocentric (body-cente...

ery excited to see Yicheng's 1st first-author paper out today! Not ignoring the bad things happening in Science and at FSU but still want to celebrate the product of all the hard work! "A Hippocampal–Parietal Network for Reference Frame Coordination" www.jneurosci.org/content/45/1...

Effects of sleep on the glymphatic functioning and multimodal human brain network affecting memory in older adults - Molecular Psychiatry Molecular Psychiatry - Effects of sleep on the glymphatic functioning and multimodal human brain network affecting memory in older adults

Poor sleep disrupts the glymphatic system in humans, which hastens dementia. Exercise improves glymphatic functioning (at least in mice).

The night’s watch: Exploring how sleep protects against neurodegeneration Parhizkar and Holtzman discuss how sleep disturbances may serve as both an early indicator and potential driver of neurodegenerative diseases, particularly in Alzheimer’s, while reviewing mechanisms u...

The night’s watch: Exploring how sleep protects against neurodegeneration: Neuron www.cell.com/neuron/fullt...

Dual orexin receptor antagonists as promising therapeutics for Alzheimer’s disease npj Biological Timing and Sleep - Dual orexin receptor antagonists as promising therapeutics for Alzheimer’s disease

Lots of NOT good things happening in the world that still shouldn't drown out the excitement of a 1st first author paper for Sydney Ragsdale! Not quite my usual work: DORAs, sleep and AD but I really enjoyed the collaboration that made this review possible! rdcu.be/ecIqo

Cell-type-specific manifold analysis discloses independent geometric transformations in the hippocampal spatial code Esparza et al. use cell-type-specific imaging and chemogenetics in freely moving mice to uncover distinct geometric and topological features of CA1 population activity during spatial navigation. Their...

Cell-type-specific manifold analysis discloses independent geometric transformations in the hippocampal spatial code: Neuron www.cell.com/neuron/fullt...

Navigational Frames of Reference as Critical Regulators of Hippocampal Interneuron Coding Properties Efficient spatial navigation relies on the hippocampus integrating local (proximal) and global (distal) cues, collectively called frames of reference, to guide behavior and support memory. Although th...

www.biorxiv.org/content/10.1...

Reinstatement and transformation of memory traces for recognition Direct brain recordings in humans show reinstatement and transformation of item-specific memory traces for recognition.

Reinstatement and transformation of memory traces for recognition | Science Advances www.science.org/doi/full/10....

Please RT - join us in Atlanta May 17-18 for the Conference for Research and Education in Navigation! Feat. navigation + space-related research (from human and animal expt. models to architectural design, robotics, and artificial agent memory and behavior)

gatech.co1.qualtrics.com/jfe/form/SV_...

Sleep microstructure organizes memory replay - Nature The temporal microstructure of the brain can multiplex distinct cognitive processes during sleep to support continuous learning.

Sleep microstructure organizes memory replay

www.nature.com/articles/s41...