Dilek Mercan

Selectively vulnerable deep cortical layer 5/6 fast-spiking interneurons in Alzheimer’s disease models in vivo Papanikolaou et al. show that deep-layer cortical neurons exhibit abnormally prolonged Ca2+ transients early in Alzheimer’s mouse models. This is linked to suppressed activity and altered tuning of fa...

Selectively vulnerable deep cortical layer 5/6 fast-spiking interneurons in Alzheimer’s disease models in vivo: Neuron www.cell.com/neuron/fullt...

Discovery of AZD4144, a Selective and Potent NLRP3 Inhibitor for the Treatment of Inflammatory Diseases Inflammatory disease is a major burden on health care, and new treatments are needed to manage exaggerated inflammatory responses. The NLRP3 inflammasome is a key player in inflammation, the activatio...

Discovery of AZD4144, a Selective and Potent NLRP3 Inhibitor for the Treatment of Inflammatory Diseases | Journal of Medicinal Chemistry pubs.acs.org/doi/10.1021/...

Response of spatially defined microglia states with distinct chromatin accessibility in a mouse model of Alzheimer’s disease - Nature Neuroscience The dynamics of microglia states adjacent to or far from amyloid-beta plaques are unclear. Here the authors show that non-plaque-associated microglia modulate the cell population expansion in response...

Response of spatially defined microglia states with distinct chromatin accessibility in a mouse model of Alzheimer’s disease

www.nature.com/articles/s41...

Alzheimer’s disease patient-derived high-molecular-weight tau impairs bursting in hippocampal neurons In mouse models, tau impairs neuronal complex spike bursting and associated network processes in hippocampus CA1 alongside CaV2.3 downregulation. Soluble high-molecular-weight tau species drive these ...

Alzheimer’s disease patient-derived high-molecular-weight tau impairs bursting in hippocampal neurons: Cell www.cell.com/cell/fulltex...

Had a great time teaching "Intracranial injections in the mouse brain" to Master of Neuroscience students from @unibonn.bsky.social It’s always very nice to work with such motivated and curious students. Looking forward to their progress in the Neuronal Circuit Dysfunction module 🧠 @dzne.science

The APOE isoforms differentially shape the transcriptomic and epigenomic landscapes of human microglia xenografted into a mouse model of Alzheimer’s disease - Nature Communications APOE is the strongest risk gene for late onset Alzheimer’s disease and its expression is upregulated in microglia in response to amyloid beta. Here, the authors show that the APOE isoforms show differ...

www.nature.com/articles/s41...

Spatial genomics of AAV vectors reveals mechanism of transcriptional crosstalk that enables targeted delivery of large genetic cargo - Nature Biotechnology Profiling transcriptional crosstalk between promoters and cell-type-specific enhancers allows large gene cargo delivery.

go.nature.com/4k7XfJw
Spatial genomics of AAV vectors reveals mechanism of transcriptional crosstalk that enables targeted delivery of large genetic cargo

Amyloid-β induces lipid droplet-mediated microglial dysfunction via the enzyme DGAT2 in Alzheimer’s disease Why microglia stop reducing amyloid deposits from Alzheimer’s disease (AD) brains is unknown. Prakash, Manchanda, et al. show that microglia increase their lipid droplets and lose their phagocytic cap...

www.cell.com/immunity/abs...

A dynamic and multimodal framework to define microglial states - Nature Neuroscience Sankowski and Prinz propose a classification framework for microglia states that considers the contextual plasticity of microglia. Their multimodal classification aligns a robust terminology with biol...

www.nature.com/articles/s41...

Had a great time at the Venusberg Meeting on Neuroinflammation — inspiring talks, great discussions, and excellent posters. I really enjoyed presenting our work from @dzne.science, reconnecting with old friends, and meeting many amazing researchers. Thanks to the organizers for this fantastic event!

APOE genotype determines cell-type-specific pathological landscape of Alzheimer’s disease Using single-nucleus RNA sequencing on post-mortem brains from control subjects and Alzheimer’s disease patients, Li et al. revealed APOE-genotype-specific molecular alterations across distinct brain ...

www.cell.com/neuron/abstr...

Enhancing the Cre-loxP system: Two new genetic tools – roxCre and loxCre – can improve the performance of the Cre-loxP system for making genetic modifications in vivo.
elifesciences.org/reviewed-pre...

Decoding microglial immunometabolism: a new frontier in Alzheimer's disease research - Molecular Neurodegeneration Alzheimer’s disease (AD) involves a dynamic interaction between neuroinflammation and metabolic dysregulation, where microglia play a central role. These immune cells undergo metabolic reprogramming i...

Decoding microglial immunometabolism: a new frontier in Alzheimer's disease research
molecularneurodegeneration.biomedcentral.com/articles/10....

Microglia aggregates define distinct immune and neurodegenerative niches in Alzheimer's disease hippocampus - Acta Neuropathologica In Alzheimer’s disease (AD), microglia form distinct cellular aggregates that play critical roles in disease progression, including Aβ plaque-associated microglia (PaM) and the newly identified coffin...

Microglia aggregates define distinct immune and neurodegenerative niches in Alzheimer's disease hippocampus
link.springer.com/article/10.1...

Plasma p‐tau217 identifies cognitively normal older adults who will develop cognitive impairment in a 10‐year window INTRODUCTION We assessed the prognostic accuracy of plasma p-tau217 in predicting the progression to mild cognitive impairment (MCI) in cognitively unimpaired (CU) individuals over a mean follow-up .....

alz-journals.onlinelibrary.wiley.com/doi/10.1002/...

Longitudinal analysis of a dominantly inherited Alzheimer disease mutation carrier protected from dementia - Nature Medicine A rare case of asymptomatic dominantly inherited Alzheimer’s reveals confined tau pathology and unique proteomic features, highlighting potential resilience mechanisms decades beyond expected onset.

Longitudinal analysis of a dominantly inherited Alzheimer disease mutation carrier protected from dementia
www.nature.com/articles/s41...

A man was destined for early Alzheimer’s ― these genes might explain his escape Scientists identify nine genetic variants that could have helped a man avoid dementia at least two decades longer than expected.

www.nature.com/articles/d41...

Congrats Róisín 👏🏼