@chandra-lab.bsky.social
Scientist-Mentor-Educator
Thank you @nmdcunha.bsky.social for hosting me for the CARAT lecture at University of Canberra. It was a pleasure interacting with you and your team.
20.06.2025 13:38 — 👍 1 🔁 1 💬 0 📌 0
#ANZSGM 2025 , Sydney
Beautiful talk by Dr. Richard Lindley on stroke management with aging
📢 BMAS Paper of the Month - May 2025
🧬 "KIAA1199 (CEMIP) regulates adipogenesis and whole-body energy metabolism" by Chen et al., published in Bone Research. KIAA1199 as a key player in understanding bone-fat crosstalk!
👏 Congrats to @kmeblab.bsky.social & Moustapha Kassem!
📖 lnkd.in/eQKBDAU5
The International Bone Marrow Adiposity Society (BMAS) invites you to our 7th BMAS Webinar, featuring Dr. Clifford J. Rosen, MD., who currently oversees the Rosen Musculoskeletal Laboratory #RosenLab at the Main Health Institute for Research, USA.
The registration link will come soon. Stay tuned!
Announcing the @BMA_Society Paper of the Month for April 2025 ! Published in @OACJournal, this study identifies a previously unrecognized role of #BMAT #lipolysis in the sub-chondral neo-osteogenesis associated with hand #osteoarthritis.
30.04.2025 11:50 — 👍 1 🔁 1 💬 0 📌 0Using histological and biochemical analyses, this new work by Mauro Maniglio, @LeaLoisay, Diego de Haro, Alexander Antoniadis, Thomas Hügle and @OA_Lab_CHUV from @RheumaLab_CHUV sheds light on a previously overlooked role of BMAT in osteoarthritis.
(Link: www.oarsijournal.com/article/S106...
This paper (www.oarsijournal.com/article/S106... ) is posted at bma-society.org, and will be archived with prior #BMAS #PoTM
30.04.2025 11:52 — 👍 1 🔁 1 💬 0 📌 0
Post 2:
Register at: umn-private.zoom.us/meeting/regi...
This seminar will discuss the regulation of both regulated and constitutive #BMAT within the context of all #adipose tissues, and how this regulatory system evolves in states such as end stage starvation and cachexia.
Post 1:
Exciting news! The 6th @BMA_Society Webinar "Neural Regulation of Marrow Adipose Tissue is coming up on April 14, 2025 at 11 AM EDT / 5PM CEST featuring Dr. Erica Scheller (@schellerlab) from @wustlcrm @WashU_MRC and Moderated by Thomas Ambrosi and @LingQin6
@bma-society.bsky.social
The International BMAS is proud to highlight -Paper of the Month (March, 2025) -published in JBMR Plus! This study explores how a high-protein diet under caloric restriction affects muscle, bone, and marrow adipose tissue (MAT). doi.org/10.1093/jbmr...
🚨 @bma-society.bsky.social is excited to announce the 3rd BMAS Summer School 2025, held virtually from 24-26 September! Registration opens March 15th. This event is for graduate students, postdocs and young researchers interested in bone marrow adiposity. For more details visit our webpage 🗣️🖥️.
06.03.2025 10:13 — 👍 6 🔁 4 💬 0 📌 0
📢 @bma-society.bsky.social Paper of the Month (February 2025): "Deep learning and genome-wide association meta-analyses of bone marrow adiposity" in @naturecomms.bsky.social This is a groundbreaking study!
@naturecomms.bsky.social @BMATscientists from @EdinUniCVS and co-authors.
Combined Romosozumab and Raloxifene treatment targets impaired bone quality in a male murine model of diabetic kidney disease. Rachel Kohler et al. Bone 28 Jan 2025 tinyurl.com/r2nw3t46 …Romo increased whole-bone strength and RAL improved tissue-level mechanical properties
06.02.2025 09:13 — 👍 0 🔁 1 💬 0 📌 0
The physico-chemical characteristics of bone mineral remain heavily debated. On the nanoscale, bone mineral resides both inside and outside the collagen fibril as distinct compartments fused together into a cohesive continuum. On the micrometre level, larger aggregates are arranged in a staggered pattern described as crossfibrillar tessellation. Unlike geological and synthetic hydroxy(l)apatite, bone mineral is a unique form of apatite deficient in calcium and hydroxyl ions with distinctive carbonate and acid phosphate substitutions (CHAp), together with a minor contribution of amorphous calcium phosphate as a surface layer around a crystalline core of CHAp. In mammalian bone, an amorphous solid phase has not been observed, though an age-dependent shift in the amorphous-to-crystalline character is observed. Although octacalcium phosphate has been postulated as a bone mineral precursor, there is inconsistent evidence of calcium phosphate phases other than CHAp in the extracellular matrix. In association with micropetrosis, magnesium whitlockite is occasionally detected, indicating pathological calcification rather than a true extracellular matrix component. Therefore, the terms ‘biomimetic’ or ‘bone-like’ should be used cautiously in descriptions of synthetic biomaterials. The practice of reporting the calcium-to-phosphorus ratio (Ca/P) as proxy for bone mineral maturity oversimplifies the chemistry since both Ca2+ and PO43- ions are partially substituted. Moreover, non-mineral sources of phosphorus are ignored. Alternative compositional metrics should be considered. In the context of bone tissue and bone mineral, the term ‘mature’ must be used carefully, with clear criteria that consider both compositional and structural parameters and the potential impact on mechanical properties.
🔥Hot off the press🔥 "Revisiting the physical and chemical nature of the mineral component of bone" 🦴🔬
doi.org/10.1016/j.ac...
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#bone #biomaterials #apatite #mineral #biomineralization #collagen #calcium #phosphate #hydroxyapatite #osteocyte #biology #medicine #osteology #osteoarchaeology
Osteoporosis is a disorder of decreased bone density that increases the risk of fractures, especially after a fall.
This JAMA Patient Page describes osteoporosis and the USPSTF recommendations for screening for #osteoporosis.
ja.ma/4aVmn2C
#MedSky
Hi, BlueSky! We´re the International Bone Marrow Adiposity Society – The premier #international research society focusing on the role of bone marrow #adipose tissue in #health and disease.
Learn more: bma-society.org
@orssociety.bsky.social #ORS2025 🎉 Excited to present our Chandra Lab @chandra-lab.bsky.social poster on Targeting Senescence-Associated Secretome to Mitigate Radiation-Induced Bone Anomalies in Phoenix!
📅 Poster Session: PS2-130
📌 Poster #: 1698
Join us!
#BoneResearch #RadiationBiology #ChandraLab
#ORS2025 🎉 Excited to present our Chandra Lab @chandra-lab.bsky.social research on Radiation-induced P21+ Senescent Myeloid Cells & Neutrophils in Bone Loss in Phoenix!
📅 Feb 8, 2025 | 9:25-9:35 AM
📌 Session 004: Bone Health & Healing
Join us!
#BoneResearch #RadiationBiology #ChandraLab
A flyer for this session entitled "Evidence-Based Advocacy to Inform Science Policy Decisions: An Orthopaedics Case Study." The session will be held on Saturday, February 8th, 2025 from 12:45-1:45 PM MT (Room North 222). Hosted By The ORS Public Outreach Committee. The featured speakers are Drs. Mary Bouxsein (Harvard Medical School) and Jennifer Westendorf (Mayo Clinic). Organizers are Drs. Jason Marvin (Harvard Medical School), Erin Mannen (Boise State Univeristy), and Sade Clayton (Washington University in St. Louis) and Bonnie Walton (Vanderbilt).
Hey #ORS2025 Attendees,
The last two weeks have shown that we as scientists need to urgently join the conversation given the devastating disruptions to biomedical research.
Interested in learning more? Join our advocacy session this Saturday, Feb. 8 from 12:45-1:45 PM.
@orssociety.bsky.social
Telomere dysfunction-induced foci : a key hallmark of cellular senescence. Red- telomere, green - gamma H2AX and yellow is the TIF foci
28.01.2025 21:23 — 👍 1 🔁 1 💬 0 📌 0
