Rosen Lab

We are SO excited that Dr. Victoria DeMambro successfully defended her PhD 🎉 Dr. DeMambro’s thesis, entitled “Tissue Nonspecific Alkaline Phosphatase: more than a pro-mineralizing enzyme”, focused on hypophosphatasia 🦴

We are SO excited to welcome Dr. Madhura Nijsure @madhura0327.bsky.social to the Rosen lab this week! As a postdoc, she is excited to explore how diet and nutrition influence bone health and homeostasis at the molecular level. Stay tuned for her amazing research!

Semaglutide for Type I Diabetes — A New Twist on an Old Story The obesity epidemic is about three decades old, and it has taken a devastating toll across the world, leading to an increase in type 2 diabetes, worsened cardiovascular outcomes, and increased rat...

Can the new wave of GLP1 medications be useful for treating Type 1 Diabetes? Check out this editorial and the associated articles in the @nejm.org to learn more!
evidence.nejm.org/doi/abs/10.1...

Looking for a fun Friday read? Check out our most recent paper exploring the inflammatory responses and lipid metabolism in bone marrow adipocytes after high calorie feeding and fasting in humans! Huge congratulations to Dr. Costa & team for such exciting work!
doi.org/10.3389/fend...

We are excited to welcome #UNECOM student Stephanie Lam to the Rosen lab! Stephanie will be working with @carolynchlebek.bsky.social to understand the effects of calorie restriction on bone and other organ systems.

Congratulations to the @asbmr.bsky.social Harold M. Frost Young Investigator Award recipients! We are excited to see our own @carolynchlebek.bsky.social among the awardees 🎉 Attend the @orssociety.bsky.social Musculoskeletal Biology Workshop to hear from the awardees about their exciting research!

Last week, we said goodbye to Dr. Costa, but we cannot wait to hear about her amazing postdoctoral research ahead at the University of Pittsburgh! Congratulations again to Dr. Costa on a fantastic thesis and research career at MaineHealth! You will be missed!

Such a bittersweet day in the lab - so proud of you @madhura0327.bsky.social! 🙌🏻

I’m so excited to see everything you’ll discover next with @cjrosenlab.bsky.social!

We can’t wait for you to start! So much exciting research ahead! 🦴🎉

🚨 Join us for the 3rd @BMAS Summer School 2025, a virtual event from Sept 24–26! Dive into cutting-edge talks, connect globally, and advance research in #BoneMarrowAdiposity 🗺️. ⏳ Deadline to apply: June 20! Submit your abstract + motivation letter now! 🧬

Curious about how follicle-stimulating hormone FSH contributes to the development of osteoporosis, obesity, and cognitive decline? Check out this recent review published in @cp-trendsmolecmed.bsky.social
www.cell.com/trends/molec...

Have you ever dreamed of isolating primary bone marrow adipocytes but were unsure of how? Check out our recent chapter in Bone Research Protocols detailing the isolation! Huge congrats to lead author, Dr. Samantha Costa! doi.org/10.1007/978-...

Curious about Long Covid? Check out this recent review summarizing the pathophysiology and clinical manifestations of Long Covid: www.id.theclinics.com/article/S089...

The Rosen lab successes continue flowing in! Shoutout to UNE Medical Student James Gray, who was recently awarded the Kahn Family Research Fellowship. James will be investigating the brain-bone connection in the context of spaceflight health, working with postdoc @carolynchlebek.bsky.social 🧠🦴👨‍🚀👩‍🚀

Huge congratulations to Dr. Samantha Costa, who placed 1st in the Fast Pitch Graduate Student Showcase through the Bioscience Association of Maine! 🎉 and right of the heels of a successful thesis defense!

We are SO excited that Dr. Samantha Costa successfully defended her PhD 🎉 Dr. Costa’s thesis, entitled “The New Obesity Paradox: How bone marrow immunosuppression leads to obesity-related bone loss and peripheral inflammation”, includes a wealth of exciting data that we will share here soon! 🦴

Maine stands up for science, and so does the Rosen lab! Science funding saves lives!

🚨Two days left to register for the upcoming Gordon Research Conference on IGF and Insulin! 🚨
Join this amazing group of researchers committed to advancing our understanding of the IGF axis's role in health and disease. Registration closes Feb 23!
www.grc.org/igf-and-insu...

Huge congratulations to Ben Aaronson and Jefferson Poserio, who placed 1st and 2nd, respectively, in the Basic Science Presentations at the Maine Osteopathic Association 2025 Midwinter Symposium last week! 🥇🥈 We love to see your hard work recognized! 🎉

New paper alert! A real team effort; collab w/ Dr. Shoshana Yakar. The SGLT2i canagliflozin (CANA) reduced cortical bone remodeling in males. CANA also caused sex-specific changes to the bone tissue metabolome that correlated with gene expression. @carolynchlebek.bsky.social doi.org/10.2337/db24...

BMAS - Shared passion for bone marrow adipose tissue We are the sole international society focusing on research of bone marrow adipose tissue (BMAT) in health and disease (musculoskeletal, metabolic, cancer)

Hi, BlueSky! We´re the International Bone Marrow Adiposity Society – The premier #international research society focusing on the role of bone marrow #adipose tissue in #health and disease.

Learn more: bma-society.org

Canagliflozin-induced adaptive metabolism in bone Sodium-glucose transporter-2 inhibitor (SGLT2i) drugs are widely used for lowering blood glucose levels independent of insulin. Beyond this, these drugs in

A detailed interrogation of how canagliflozin impacts bone metabolism and markers of bone formation and resorption in male vs. female 6-month-old genetically heterogeneous UM-HET3 mice diabetesjournals.org/diabetes/art...

Does sex affect the risk of developing long COVID? Unfortunately, yes! New research from RECOVER demonstrates that compared to males, females have increased risk of developing long COVID. #JAMANetworkOpen
doi:10.1001/jamanetworkopen.2024.55430

We are ending our week by celebrating lab member, Phuong Le, for all her amazing work in the MaineHealth community! Congratulations, Phuong! We appreciate all your hard work, both in the lab and around the institute!

We are excited to welcome James Gray, a medical student from #UNECOM, to the Rosen lab! James will be working with @carolynchlebek.bsky.social to investigate skeletal changes relevant to astronauts 🚀🦴

Did you know that >70% of patients in the US with fragility fractures did not have documented osteoporosis? New research by a team of talented individuals, including our own Dr. Rosen, highlights underuse of osteoporosis drug therapies @endosocjournals.bsky.social #JCEM
doi.org/10.1210/clin...

In case you missed the December issue of JBMR Plus, be sure to check it out - we were psyched that our research was chosen as cover art! Huge thanks to Peter Caradonna, who helped process these samples 🎉 And congrats to lab member @carolynchlebek.bsky.social, who led this study!

Are you interested in the far-reaching effects of IGF? Nutritional Interventions, Inflammation, Central Nervous System, Cancer, and more! Join us in Ventura, CA to talk IGF! Register now www.grc.org/igf-and-insu...

🚨Postdoc Job Alert! 🚨 Join our team & work in beautiful coastal Maine! We are looking for a postdoc to start in 2025 who will investigate the interactions between metabolism & the skeleton. Interest in muscle is also welcome. Please share widely! mcusercontent.com/fc0c2f559847...

We are so excited to see our amazing leader, Dr. Cliff Rosen slated to give a talk during the Keynote session of the IGF & Insulin System in Physiology and Disease Gordon Conference! Register soon so you can learn about IGF and more! www.grc.org/igf-and-insu...