Joel Credle

𝗖𝗼𝗵𝗼𝗿𝘁 𝘀𝘁𝘂𝗱𝘆 𝗼𝗳 𝘁𝗵𝗲 𝘄𝗲𝗲𝗸 “𝗦𝗼𝗰𝗶𝗮𝗹 𝗱𝗶𝘀𝗮𝗱𝘃𝗮𝗻𝘁𝗮𝗴𝗲 𝗮𝗰𝗰𝗲𝗹𝗲𝗿𝗮𝘁𝗲𝘀 𝗮𝗴𝗶𝗻𝗴” Nature Med 2025 by @mikakivimaki.bsky.social & Joni V. Lindbohm links 14-protein plasma signatures to accelerated aging & disease risk via immune pathways.
#ProteomicSignatures #AgingBiomarkers #Reactome
www.nature.com/articles/s41...

Cohort Study of the Week: Oh & Wyss-Coray from Stanford University show in Nature Medicine that the CSF YWHAG:NPTX2 ratio predicts cognitive decline years before Alzheimer’s symptoms, outperforming traditional biomarkers.

#AlzheimerDisease #CSFBiomarkers #Proteomics

www.nature.com/articles/s41...

🌟 Cohort Study of the Week! 🌟 From derosalab.bsky.social Gut dysbiosis linked to survival in 955 cancer patients. The balance of Akkermansia & sMAdCAM-1 are crucial for prognosis. Important #PrecisionOncology!

pubmed.ncbi.nlm.nih.gov/40189749/
#CancerResearch #Microbiome #Oncology

Infinity Bio’s Cohort of the Week: Bos & Zambrana find inapparent DENV; Kasbergen & Koopmans track ZIKV. Multiplex serology reveals infection dynamics.
www.thelancet.com/journals/lan...
academic.oup.com/jid/advance-...

#CohortOfTheWeek A pivotal study on the association of anti-viral antibodies & neural autoantibodies in psychiatric disorders. Analyzing CSF/serum from patients, they found a significant link, suggesting CNS viral infection could trigger autoantibody generation
pubmed.ncbi.nlm.nih.gov/40382511/

New #CohortOfTheWeek from Infinity Bio! Latent #EBV infection surprisingly impacts #Type1Diabetes treatment efficacy! Yale researchers found EBV-positive patients show improved responses to teplizumab. #Immunology #AutoimmuneDisease
[Link: www.nature.com/articles/s41...

Plasma proteome variation and its genetic determinants in children and adolescents - Nature Genetics This mass spectrometry-based proteomic study profiles the plasma proteome in 2,147 children and adolescents and reveals its association with age, sex, puberty, body mass index and genetics.

Cohort study: “Plasma proteome variation and its genetic determinants in children and adolescents” by @liliniu.bsky.social Simon Rasmussen, Torben Hansen, mannlab.bsky.social maps 1,200+ proteins & genetic drivers in 2,100+ youth
#MassSpectroscopy #Plasma #Proteomics www.nature.com/articles/s41...

Cohort study of the week “Proteomic changes upon treatment with semaglutide in individuals with obesity” (Nature Medicine Jan 2025) by Lasse Maretty, Abd Tahrani & Milan Geybels reveals proteomic shifts in STEP 1 & 2 trials #Semaglutide #GLP1ReceptorAgonist #Proteomics www.nature.com/articles/s41...

𝗖𝗼𝗵𝗼𝗿𝘁 𝘀𝘁𝘂𝗱𝘆 𝗼𝗳 𝘁𝗵𝗲 𝘄𝗲𝗲𝗸: “Preclinical Protein Signatures of Crohn’s Disease and Ulcerative Colitis” by Dr. Oscar Grännö & Jonas Halfvarson reveals blood-based proteomic biomarkers that precede IBD diagnosis.

#IBDResearch #Proteomics #Biomarkers

lnkd.in/eTr8TWtH

Cohort study: "Multi-cohort CSF proteomics identifies robust molecular signatures in Alzheimer's disease" by Muhammad Ali & Carlos Cruchaga. Large-scale analysis uncovers molecular signatures associated with Alzheimer's.
#Proteomic #Antibody #EarlyDetectionAD
www.cell.com/neuron/fullt...

The first authors developed an integrative model, Mal-ID.To address a gap in current diagnostic medical practices, which do not yet utilize the adaptive immune system’s B cell receptor (BCR) and T cell receptor (TCR) sequences in diagnosis.

https://onlinelibrary.wiley.com/doi/10.1002/ana.27157

Cohort study of the week: Atlas of Cerebrospinal Fluid Immune Cells Across Neurological Diseases by Heinz Wiendl, Gerd Meyer zu Hörste, & Michael Heming. This analysis of cerebrospinal fluid & blood samples explores immune cell profiles across neurological conditions.

I've temporarily revived my X account. No science or chit chat. Purely to boost the resistance against the misinformation and anti science propaganda.

Multiomics reveal key inflammatory drivers of severe obesity: IL4R, LILRA5, and OSM Chen et al. analyzed gene expression in Hispanic Latino individuals with severe obesity (BMI ≥40 kg/m2) in comparison to controls, following up their 124 findings with subcutaneous adipose tissue expr...

Interesting study by Kari E. North & Jennifer E. Below from @uncpublichealth.bsky.social & vumedicine.bsky.social ChenHungHsin & Heather M. Highland uncover IL4R, LILRA5 & OSM as inflammatory drivers in severe obesity via #multiomics. Could #antibody profiling add deeper immune insights? #Inspiring

👋 We're Infinity Bio Inc, and We Read Antibodies 🔬 Decoding the antibody reactome with our unique MIPSA tech: complete immune target panels, cutting-edge data science, and top-notch quality. Learn more: www.infinitybio.com #antibodies #immunology #proteomics #datascience #MIPSA

Infinity Bio Launches Comprehensive Mouse Antibody Reactome Profiling Service Infinity Bio is pleased to announce the release of their MuSIGHT™ mouse autoantibody reactome service offering. Defining an animal’s autoantibody reac

Big news for #preclinical #research! 🐭 Unveiling MuSIGHT™: comprehensive mouse autoantibody analysis powered by MIPSA! Explore the entire mouse proteome with 273,000+ sequences. Learn more & advance your #immunology work: businesswire.com/news/home/20... & infinitybio.com/musight/ #antibody #immune

🔬 Join Ben Larman, CSO of Infinity Bio, to explore frameworks transforming biotech. Discover DNA barcoding, AI-driven breakthroughs, and the art of impactful storytelling.

🎙️ Listen now! https://buff.ly/4121uj0

#Biotech #AI #Innovation #Leadership

Dual Probe Ligation In Situ Hybridization with Rolling-Circle Amplification for High-Plex Spatial Transcriptomics New biological insights are increasingly dependent upon a deeper understanding of tissue architectures. Critical to such studies are spatial transcriptomics technologies, especially those amenable to ...

Another amazing paper out of Ben Larman's lab out of JHU-SOM

“Exciting progress in spatial transcriptomics! A new method, LISH-LnR, enables detailed high-plex mRNA analysis in FFPE. #Biotech #Research #SpatialTranscriptomics

www.biorxiv.org/content/10.1...

Hillary ran so that future women could win.

She took all the arrows, fought the good fight, and put 65 million cracks in that glass ceiling.

No one is more deserving of the Presidential Medal of Freedom. Congratulations, Secretary Clinton. 💙

President Biden just announced the newest recipients of the Presidential Medal of Freedom. Names include:

Hillary Clinton
José Andrés
Jane Goodall
George Soros
Earvin "Magic" Johnson
Bono
Fannie Lou Hammer
Bill Nye
George Romney
Denzel Washington
Anna Wintour

Cervical cancer deaths drop among younger women; study credits HPV vaccine The HPV vaccine has led to a significant drop in cervical cancer deaths among younger women, with a 62 percent decline in mortality over the last decade.

#Vaccines. www.washingtonpost.com/wellness/202...
Need we say more about the benefits of vaccines.

Global immunization efforts have saved at least 154 million lives over the past 50 years A major landmark study reveals that global immunization efforts have saved an estimated 154 million lives – or the equivalent of 6 lives every minute of every year – over the past 50 years. The vast m...

www.who.int/news/item/24...
For those who don't know or refuse to accept, here are some facts about #vaccines.

With the new administration taking office and the potential for RFK Jr., who is not a #scientist, to oversee the #HHS including the #CDC, #FDA, #NIH, and Disease Registry, #ARPA, and several other key agencies—I wanted to preserve certain information that may soon become less accessible.

New to Bluesky and haven't posted anything yet but here it goes as we crash into 2025.......

This is Ronald Rowe, the Director of the United States Secret Service and a 30-year veteran of law enforcement. Today, GOP Rep. Pat Fallon politicized the victims of 9/11 to launch a disgusting attack against him.

REPOST if you stand with Director Rowe against the GOP!

Covid oggi Italia, bollettino e dati ultima settimana Casi, decessi e dati dal 21 al 27 novembre

Italy: 2,122 new infections and 47 deaths were reported in the last week.

From 21 November to 27 November 2024:

🔹Reported cases: 2,122 (-17%)
🔹Deaths: 47 (-23%)
🔹Positivity rate: 3.6% (-0.6%)

🔸Hospitalised: 1,357 (-2%)
🔸ICU: 58 (-6%)

#COVID19Italy

www.adnkronos.com/salute/covid...

Study confirms face masks' effectiveness in reducing disease transmission, calls for improved public understanding Researchers reviewed the benefits, practicalities, and harms of masks and masking, finding that masks are effective in reducing respiratory disease transmission despite some adverse effects, and empha...

When the mask mandate was lifted from Mass General Brigham in May '23, hospital transmission of resp virus went up. When the mandate was re-instituted in Jan '24, infection rates went down. www.news-medical.net/news/2024052...