Targeting the Hippo pathway
Targeting the Hippo pathway in cancer www.nature.com/articles/s41...
rdcu.be/et8aj
This new Review discusses emerging Hippo pathway-targeted therapies for cancer, particularly those that target TEAD DNA binding proteins and their interaction with the YAP/TAZ transcription co-activators
30.06.2025 14:26 — 👍 3 🔁 1 💬 0 📌 0
Targeting the Hippo pathway in cancer
Nature Reviews Drug Discovery - The Hippo signalling pathway fulfils a vital role in the regulation of tissue homeostasis and organ development and its dysregulation is associated with several...
Pleased to share our review in @natrevdrugdiscov.nature.com. 20+ years after the Hippo pathway was discovered in Drosophila, the first targeted therapies are in clinical trials for cancer and heart disease.
Big thanks to co-author Tracy Tang from Vivace Therapeutics. #TEADinhibitors
rdcu.be/et2NL
02.07.2025 23:50 — 👍 2 🔁 1 💬 0 📌 0
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