Chase Francis

December 5, 2025 Dear Colleague: We are writing to reaffirm our commitment to ensuring widespread access to vaccines in Maryland and to following evidence-based vaccination guidance, including to the extensive evidence that supports the safety and effectiveness of routine administration of hepatitis B vaccine to newborns and completing the full vaccination series in accordance with the American Academy of Pediatrics' Recommended Child and Adolescent Immunization Schedule. As detailed in a statement by the Northeast Public Health Collaborative, of which Maryland is a member, hepatitis B is a viral infection that attacks the liver and can cause both acute and chronic disease, including cirrhosis, liver failure, liver cancer, and death.' Hepatitis B infection is particularly devastating to infants? Of infants infected with the virus in the first year of life, 90% develop chronic hepatitis B. One in four people infected with hepatitis B virus during childhood die from liver cirrhosis or liver cancer in later life. This can be prevented by vaccination. The hepatitis B vaccine has been tested extensively for safety and efficacy, and when administered within 24 hours of birth (birth dose), is highly effective in preventing newborn infection. Hepatitis B vaccine has a strong safety profile, with adverse effects that are typically mild and transient. According to post-licensure monitoring, the most frequently reported reactions include localized pain, erythema, or swelling at the injection site, as well as low-grade fever and fatigue, all of which generally resolve within 24-48 hours. Large meta-analyses and systematic reviews that include millions of children have consistently found no link between vaccines and autism. 5,6 Severe adverse reactions are estimated to occur at a rate of 1.1 per million doses, consistent with the overall rate of anaphylaxis to vaccines.? Among healthy infants, 25%, 63% and 95% achieve anti-HBs levels ≥10 mlU/mL after the first,

Sad that it was necessary but grateful to be in a state that is a member of Northeast Public Health Collaborative to provide clear, evidence based recommendations to clinicians and the patients they care fore

Analysis: OpenAI is a loss-making machine, how can it survive? Don't call it a bubble! Loss-making monster OpenAI is on the hook for $1.4 trillion (with a T) in compute commitments. How can this go on?

"All of this falls apart if humans don't adopt the tech. This is why you've seen Meta cram its lame chatbots into WhatsApp and Instagram. This is why Notepad and Paint now have useless Copilot buttons on Windows. This is why Google Gemini wants to "help you" read and reply to your emails."

‘Nature’s original engineers’: scientists explore the amazing potential of fungi Unique properties of fungi have led to groundbreaking innovations in recent years, from nappies to electronics

The future is fungal

www.theguardian.com/science/2025...

Continued damage to scientific independence from political interference - NIH is now asserting the authority to terminate any grant at any time, for any reason, at the discretion of the awarding agency. (grants.nih.gov/grants/guide...).

HHS devises legal playbook for future grant terminations, internal memo shows Exclusive: HHS devises a legal playbook for future research grant terminations, an internal memo shows.

Update on a significant development NIH grant terms.

On 10/1, a change to grant making regs went into effect that gives NIH more power to terminate grants for policy reasons.

But to use this power, new grant terms must include specific language. See @aniloza.bsky.social w/ the story from July.

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Young brain researchers ponder other careers amid federal funding cuts Cuts and disruptions to federal research funding are causing many young brain scientists to reconsider their career choice.

On NPR's nationally syndicated radio program "All Things Considered," three SfN members speak about the funding and career challenges facing the neuroscience community.

🔗 vist.ly/4enax

#NeuroAdvocate #SfN25 #neurosky #neuroskyence

Superior colliculus projections drive dopamine neuron activity and movement but not value To navigate dynamic environments, animals must rapidly integrate sensory information and respond appropriately to gather rewards and avoid threats. It is well established that dopamine (DA) neurons in...

Check out our latest, online now at @sfnjournals.bsky.social www.jneurosci.org/content/earl...

Director Bhattacharya "Let's fund emerging investigators"

Yeah, who's the idiot running NIH who allowed 15% or few fewer early stage investigators be funded in FY2025 compared to FY2024?

(Estimate: The official numbers are not yet available (at least publicly)

The Next Terrorist Attack And What Comes After (Updated)

Far more frightening than anything Halloween-related is pondering what @timothysnyder.bsky.social writes on here. open.substack.com/pub/snyder/p...

Mouse brain coronal section with tyrosine hydroxylase stained with gfp fluorescence in the ventral tegmental area and substantia nigra

Told myself I was going to stay away from the midbrain but the data keeps pushing me towards it. Happy fluorescence friday!
Credit to post doc Dr. Desh Deepak Ratna

How New Trump Multiyear Policy Makes NIH Grants Even Harder To Get The new Trump administration multiyear funding policy for NIH grants has dropped National Cancer Institute grant funding rates from one in 10 applicants to one in 25.

#TobRegSky #PedSky #MedSky #EpiSky #addictionsci #policysky #polisky #neuroskyence #neurosci 🧪🛟🫁

Excellent reporting by @bruceylee.bsky.social in @forbes.com about the new NIH multi year funding policy decimating US biomedical research.

www.forbes.com/sites/brucel...

Higher education fails at collective action In the latest development in the ongoing combat between universities in the United States and the Trump administration, the Department of Education has presented them with what it calls a “compact.” I...

"It's past time to recognize that university administrators aren't going to lead the way out of this, [setting] the stage for leadership... from faculty, staff, & students, [where] most if not all progress in higher ed over the past 100 yrs has occurred."
www.science.org/doi/10.1126/...
#AcademicSky

Python was awarded a funding grant, funding grant asked Python foundation to remove all diversity and inclusion initiatives they have.

Python foundation said no and rejected the grant.

If you use Python, send a few dollars to the charity to keep it going. I’m pushing a dono on behalf of ScamGuard.

NIH Leadership Is Failing Early Career Researchers Halted training programs, funding chaos, and hiring freezes jeopardize advancement options for early career researchers.

Thoughtful and well-informed op-ed from @ianlmorgan.bsky.social

Definitely worth a read!

www.the-scientist.com/nih-leadersh...

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‘Fear and hopelessness’: study finds one in four professors consider leaving US south Survey by American Association of Professors shows nearly quarter of respondents are switching due to states’s politics

Discussing this phenomenon w/ a group of profs. Someone morbidly joked, “& northern profs are fleeing the country.” The next person said…”even if we were all willing & able to abandon this place there are not enough jobs for us globally and the U.S. employs a huge # of international scholars too.”

Cutting the NIH—The $8 Trillion Health Care Catastrophe This JAMA Forum discusses the recent budget cuts to National Institutes of Health (NIH), the effects of these cuts on scientific research and health of individuals in the US, and the prospects for cha...

Two Harvard economists forecast the impact of the administration’s proposed NIH budget cuts- stunning losses in new therapies, life expectancy, and economic output with a “social cost 16 times greater than the savings the administration is attempting to achieve."

jamanetwork.com/journals/jam...

"What have we learned, Palmer?" "I don't know, sir." "I don't know either. I guess we learned not to do that again."

What reading the news feels like every damn day now:

Autism does not need to be cured

Ableism does

The end

Pretty clear illustration of "you may as well stand up for what you believe in, they're coming for you anyway."

(1/10) We’re excited to share our new preprint (doi.org/10.1101/2025...), which uncovers the spatiomolecular landscape of the human nucleus accumbens (NAc), by integrating snRNA-seq with Visium spatial transcriptomics across 10 control donors. 🧠 #NAcLIBD #snRNAseq #10xVisium

But starting in the late 1980s, that investment in basic science began to pay off, driving a revolution in the molecular biology of cancer. Though it took decades, the cancer investment increase in the 1970s has led to a cornucopia of new cancer cures today. Immunotherapies, CAR-T cell treatments, checkpoint inhibitors, and precision drug targeting are all a product of that basic science work. And that progress has contributed to increased quality of life. Between 1991 and 2019, the risk of dying of cancer dropped by 31%. This is a common story for basic scientific research: it's a long-term investment, one that only governments have the time horizon to make, and it brings enormous payoffs. The payoffs are both economic, generating jobs, and in better health, generating cures. And the US scientific research system is complex, painstakingly constructed, and easy to

The VC model is the antithesis of good basic science.

Basic science is best when many labs are funded over the long-term, when many different scientists pursue their own ideas. Let a thousand flowers bloom —and support them.

VC investment is about relentless, exponential growth.

The way the mainstream media is treating Charlie Kirk’s bigotry is the way a highly dysfunctional family treats racist crazy pedo grandpa. “Oh come on, that’s just how he is, he doesn’t mean It, that doesn’t count.”

Abstract: Under the banner of progress, products have been uncritically adopted or even imposed on users — in past centuries with tobacco and combustion engines, and in the 21st with social media. For these collective blunders, we now regret our involvement or apathy as scientists, and society struggles to put the genie back in the bottle. Currently, we are similarly entangled with artificial intelligence (AI) technology. For example, software updates are rolled out seamlessly and non-consensually, Microsoft Office is bundled with chatbots, and we, our students, and our employers have had no say, as it is not considered a valid position to reject AI technologies in our teaching and research. This is why in June 2025, we co-authored an Open Letter calling on our employers to reverse and rethink their stance on uncritically adopting AI technologies. In this position piece, we expound on why universities must take their role seriously toa) counter the technology industry’s marketing, hype, and harm; and to b) safeguard higher education, critical thinking, expertise, academic freedom, and scientific integrity. We include pointers to relevant work to further inform our colleagues.

Figure 1. A cartoon set theoretic view on various terms (see Table 1) used when discussing the superset AI (black outline, hatched background): LLMs are in orange; ANNs are in magenta; generative models are in blue; and finally, chatbots are in green. Where these intersect, the colours reflect that, e.g. generative adversarial network (GAN) and Boltzmann machine (BM) models are in the purple subset because they are both generative and ANNs. In the case of proprietary closed source models, e.g. OpenAI’s ChatGPT and Apple’s Siri, we cannot verify their implementation and so academics can only make educated guesses (cf. Dingemanse 2025). Undefined terms used above: BERT (Devlin et al. 2019); AlexNet (Krizhevsky et al. 2017); A.L.I.C.E. (Wallace 2009); ELIZA (Weizenbaum 1966); Jabberwacky (Twist 2003); linear discriminant analysis (LDA); quadratic discriminant analysis (QDA).

Table 1. Below some of the typical terminological disarray is untangled. Importantly, none of these terms are orthogonal nor do they exclusively pick out the types of products we may wish to critique or proscribe.

Protecting the Ecosystem of Human Knowledge: Five Principles

Finally! 🤩 Our position piece: Against the Uncritical Adoption of 'AI' Technologies in Academia:
doi.org/10.5281/zeno...

We unpick the tech industry’s marketing, hype, & harm; and we argue for safeguarding higher education, critical
thinking, expertise, academic freedom, & scientific integrity.
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How RFK Jr.’s misguided science on mRNA vaccines is shaping policy − a vaccine expert examines the false claims Chaos at the CDC and the sharp move away from mRNA vaccines has public health experts alarmed.

If you’re wondering how much of what RFK Jr said yesterday about vaccines was true—almost none of it was.

@FullerLab_UW is one of the most accomplished vaccinologists out there and her article is required reading to separate truth from falsehoods.

theconversation.com/how-rfk-jr-s...

Don’t trust the experts”? That’s not democracy, that’s recklessness.

On a plane, I want a pilot.
In a hospital, I want doctors and scientists who understand the evidence.

Expertise isn’t religion or authoritarianism — it’s training, accountability, and data.

Ignore it and we all pay the price.

Establishing a Fixed Time Period of Admission and an Extension of Stay Procedure for Nonimmigrant Academic Students, Exchange Visitors, and Representatives of Foreign Information Media Unlike most nonimmigrant classifications, which are admitted for a fixed time period, aliens in the F (academic student), J (exchange visitor), and most I (representatives of foreign information media...

Very few PhD students finish within 4 years. But international students will need to do that if US proposed visa rules change go through.

Sound reasonable to you?

Fed register is accepting comments for next month. Details at the link & comment button

www.federalregister.gov/documents/20...

Tell the Supreme Court: No Stay. Hands off NIH The Supreme Court is poised to allow Trump to illegally terminate NIH grants. Let's speak out. There is not much time.

Important new document available regarding SCOTUS and NIH grants.

scienceandfreedomalliance.substack.com/p/tell-the-s...

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Improving Oversight of Federal Grantmaking By the authority vested in me as President by the Constitution and the laws of the United States of America, and to improve the process of Federal

1. Federal funding for research promotes tech, biomedical, and scientific discovery in the US, and provides training for the sci/tech workforce that has brought immeasurable wealth to the US over the past 75 years.

Today's executive order includes a provision that will obliterate both functions.

Disenchanted PI and post doc with boxes over their head, one with an angry face drawn on the box, the other with a dead face and tongue out. They are standing in front of chemical hoods and surrounded by boxes, totally not losing their minds.

Packing our lab up and headed to Baltimore and @um-mind.bsky.social next week! I'd say packing is going well...