Davide Giampiccolo

(PDF) The inferior fronto-occipital fasciculus: bridging phylogeny, ontogeny and functional anatomy PDF | The inferior-fronto-occipital fasciculus is a long-range white matter tract that connects the prefrontal cortex with parietal, posterior temporal... | Find, read and cite all the research you ne...

9/ Finally, thank you so much to @EpilepsyInst to support this work!

🔗 Read the full article in @brain1878.bsky.social :

www.researchgate.net/publication/...
#neuroscience #brain #executivecontrol #neuroanatomy

8/ We believe this work offers new insights into the IFOF’s role beyond semantics and invites further exploration into its broad executive functions.

7/ Clinically, this pathway’s importance in neurosurgery is clear: it should be considered a key target for preservation in both hemispheres (against the myth of a non-dominant right hemisphere).

6/ This unified view links language, visual processing, motor cognition, theory of mind, reading, attention, and emotion recognition—grounding cognitive control in top-down modulation of visual features. It also posits a role for the right IFOF in social semantic control.

5/ Using stimulation, we propose it can be subdivided in two-layers:
🔹 Ventral IFOF: Cognitive control for conceptual/symbolic content (including language).
🔹 Dorsal IFOF: Cognitive control for perceptual content

4/ We propose that the IFOF overlays cortical regions involved in semantic control and the multiple demand system, representing an executive, prefrontal connection for top-down modulation of visual features. It is language-sensitive, but not language-specific.

3/ Our review challenges the idea that the IFOF evolved for language. Gathered data indicate that this pathway is present along the primate lineage—far earlier than language—suggesting it originally supported top-down cognitive control of visual features for goal-directed behaviour.

2/ Since then, the IFOF has been considered the major anatomical pathway linking language to meaning, but objections have emerged suggesting its function goes beyond language.

New insights into the anatomo-functional connectivity of the semantic system: a study using cortico-subcortical electrostimulations Abstract. Despite a better understanding of the organization of the cortical network underlying the semantic system, very few data are currently available

1/ Almost 20 years ago, we reported that the IFOF supports language semantics through causal, direct stimulation [Duffau et al., Brain (2005)]. This work laid the foundation for understanding its role in the ventral stream of language.

academic.oup.com/brain/articl...

🧵 Excited to share our latest review, published in @brain1878.bsky.social, on the inferior fronto-occipital fasciculus (IFOF)!

@ucl.ac.uk – paper at the end of the thread:

7/ Clinically, this pathway’s importance in neurosurgery is clear: it should be considered a key target for preservation in both hemispheres (against the myth of a non-dominant right hemisphere).

6/ This unified view links language, visual processing, motor cognition, theory of mind, reading, attention, and emotion recognition—grounding cognitive control in top-down modulation of visual features. It also posits a role for the right IFOF in social semantic control.

5/ Using stimulation we propose it can be subdivided in two-layers:
🔹 Ventral IFOF: Cognitive control for conceptual/symbolic content (including language).
🔹 Dorsal IFOF: Cognitive control for perceptual content.

4/ We propose that the IFOF overlays cortical regions involved in semantic control and the multiple demand system, representing an executive, prefrontal connection for top-down modulation of sensory features. It is language-sensitive, but not language-specific.

3/ Our review challenges the idea that the IFOF evolved for language. Gathered data indicate that this pathway is present along the primate lineage—far earlier than language—suggesting it originally supported top-down cognitive control of visual features for goal-directed behaviour.

2/ Since then, the IFOF has been considered the major anatomical pathway linking language to meaning, but objections have emerged suggesting its function goes beyond language.

New insights into the anatomo-functional connectivity of the semantic system: a study using cortico-subcortical electrostimulations Abstract. Despite a better understanding of the organization of the cortical network underlying the semantic system, very few data are currently available

1/ Almost 20 years ago, we reported that the IFOF supports language semantics through causal, direct stimulation [Duffau et al., Brain (2005)]. This work laid the foundation for understanding its role in the ventral stream of language.
academic.oup.com/brain/articl...

Cortico-hippocampal networks underpin verbal memory encoding in temporal lobe epilepsy In this cross-sectional study of 84 hippocampal sclerosis patients and 43 healthy controls, Fiore et al. linked verbal learning variability to cortical and

A new study in Brain Comms included 84 people with epilepsy due to hippocampal sclerosis and 43 controls to test how structural abnormalities shape verbal memory.
@dgiampiccolo.bsky.social
@braincomms.bsky.social
doi.org/10.1093/brai...

So well deserved, @aabjamjoom.bsky.social . Really, sky is the limit!

Long-term memory plasticity in a decade-long connectivity study post anterior temporal lobe resection - Nature Communications Using functional MRI, the authors tracked memory recovery over a decade after epilepsy surgery, revealing key brain changes in spared medial temporal structures and contralateral regions, highlighting...

How does memory evolve after epilepsy surgery? For the better it seems!
--> doi.org/10.1038/s414...
@uclqsion.bsky.social @dgiampiccolo.bsky.social