Jamie Hanson

Chatted with colleagues at @acamh.bsky.social about a recent paper... and wondered about how silly I looked... I guess I will know soon.

Check out our new paper evaluating the performance of five brain age algorithms in two population-based cohorts of youth 🧠

@ohbmofficial.bsky.social

Linking obesity with white matter microstructure highlights the importance of brainstem tracts and sex differences Gurholt et al. report associations between obesity and regional white matter phenotypes across commonly used diffusion magnetic resonance imaging metrics,

Linking obesity with white matter microstructure highlights the importance of brainstem tracts and sex differences academic.oup.com/braincomms/a...

A Systematic Evaluation of the Performance of Multiple Brain Age Algorithms in Two Cohorts of Youth Performance of five influential brain age estimation algorithms in two population-based cohorts of youth. Brain age was quantified using estimates of brain structure, and performance was evaluated ba....

A Systematic Evaluation of the Performance of Multiple Brain Age Algorithms in Two Cohorts of Youth
onlinelibrary.wiley.com/doi/full/10....

Left: Pathways involved in brain energy metabolism. Energy metabolism refers to processes involved in energy production from nutrient molecules. Glucose is the main energy source in the brain under normal physiological conditions. Glucose entering brain cells can be utilized in three parallel pathways. It can be processed through glycolysis to produce 2 ATP and 2 pyruvate molecules (blue). Lactate dehydrogenases catalyze the interconversion of lactate and pyruvate (purple). Pyruvate is transported into mitochondria, where it enters the TCA cycle to generate high-energy electron carriers NADH and FADH2 (green), driving the complete oxidation of glucose through the mitochondrial electron transport chain (red). Glucose entering the brain can also enter the PPP. PPP is an anabolic pathway that uses glucose to produce 5-carbon sugars and NADPH, an essential co-factor used in nucleotide and lipid biosynthesis (yellow). Glucose can also be stored in the form of glycogen via glycogen synthase, a process mainly active in astrocytes. Right: Energy pathway maps. Colors show z-scored mean expression values across all genes in each pathway. ppp, pentose phosphate pathway; tca, tricarboxylic acid cycle; oxphos, oxidative phosphorylation; lactate, lactate metabolism and transport.

How are energy #metabolism pathways distributed across the #cortex? @alaindagher.bsky.social &co map five pathways in the human #brain, linking metabolic organization with brain structural & functional properties, as well as developmental dynamics @plosbiology.org 🧪 plos.io/4c1JVp8

🧠 Not all brain age algorithms are equal!

In our new study, one algorithm (Pyment) outperformed other models in youth. Algorithms fail when your sample's age range is narrow or mismatched with training data. So, choose wisely...

onlinelibrary.wiley.com/doi/10.1002/...

#BrainAge #Neuroimaging

🧠 Not all brain age algorithms are equal!

In our new study, one algorithm (Pyment) outperformed other models in youth. Algorithms fail when your sample's age range is narrow or mismatched with training data. So, choose wisely...

onlinelibrary.wiley.com/doi/10.1002/...

#BrainAge #Neuroimaging

New paper in @acamh.bsky.social's JCPP! We found that early adversity doesn't affect positive emotions uniformly-- youth follow 4 distinct developmental trajectories. & This heterogeneity matters for understanding depression/anxiety risk.
🧵 1/5

📊 Paper: acamh.onlinelibrary.wiley.com/doi/10.1111/...

a man is standing in front of a sign that says believe on it . ALT: a man is standing in front of a sign that says believe on it .

And... Early identification of youth with persistently low positive affect could enable targeted interventions focused on enhancing positive emotional experiences-- before depressive symptoms fully emerge.

Full paper (open access): acamh.onlinelibrary.wiley.com/doi/10.1111/... 5/5

Notably-- Persistently LOW positive affect specifically mediated the link between adversity → internalizing symptoms (depression/anxiety), but NOT externalizing problems.

This suggests distinct mechanistic pathways rather than general psychopathology risk. 4/5

The stark reality...

As early life adversity increases, probability of staying in the High-Stable group drops from ~25% to just 4-8.5%. Meanwhile, Declining trajectory membership rises to 65-70% at highest adversity levels. 3/5

a woman in a floral jacket is making a gesture with her hands and smiling . ALT: a woman in a floral jacket is making a gesture with her hands and smiling .

Using person-centered trajectory modeling in 7,457 youth from the ABCD-study, we identified:

High-Stable (28%)
Declining (25%)
Persistently Low (24%)
Volatile (23%)

Rather than assuming everyone responds the same way to adversity, we let the data reveal natural subgroups. 2/5

New paper in @acamh.bsky.social's JCPP! We found that early adversity doesn't affect positive emotions uniformly-- youth follow 4 distinct developmental trajectories. & This heterogeneity matters for understanding depression/anxiety risk.
🧵 1/5

📊 Paper: acamh.onlinelibrary.wiley.com/doi/10.1111/...

JCPP Advances | ACAMH Child Development Journal | Wiley Online Library Machine learning based prediction of cognitive resilience among low income youth.

In our 🚨 NEW PAPER 🚨 "Beyond the income-achievement gap: The role of individual, family, and environmental factors in cognitive resilience among low-income youth", we used machine learning to characterise predictors of cognitive resilience.

acamh.onlinelibrary.wiley.com/doi/full/10....

The role of the ‘word gap’ for the intergenerational transmission of education: A genetically sensitive study osf.io/preprints/ps...

Synchrony between brain age and internalising and externalising symptoms across adolescence www.medrxiv.org/content/10.6...

An unbiased comparison of 14 epigenetic clocks in relation to 174 incident disease outcomes - Nature Communications Epigenetic clocks estimate biological age and health risks. Here, the authors compare 14 clocks in 18,859 individuals, showing second-generation clocks better predict disease incidence and mortality, ...

An unbiased comparison of 14 epigenetic clocks in relation to 174 incident disease outcomes www.nature.com/articles/s41...

When the science alone is not enough: embracing our responsibility as science communicators www.nature.com/articles/s41...

White matter microstructure alterations in social anxiety disorder – a mega-analysis across 12 cohorts in the ENIGMA-Anxiety Working Group Studies investigating social anxiety disorder (SAD) have reported inconsistent alterations in white matter (WM) microstructure. The ENIGMA-Anxiety Wor…

White matter microstructure alterations in social anxiety disorder – a mega-analysis across 12 cohorts in the ENIGMA-Anxiety Working Group www.sciencedirect.com/science/arti...

Inferring intrinsic neural timescales using optimal control theory www.nature.com/articles/s41...

Distinct Roles of Positive and Negative Maternal Mental Health in Parenting Styles and Child Development Maternal mental health significantly impacts child development, yet the role of positive maternal mental health in shaping parenting and child outcome…

Distinct Roles of Positive and Negative Maternal Mental Health in Parenting Styles and Child Development www.sciencedirect.com/science/arti...

Vulnerability to memory decline in aging revealed by a mega-analysis of structural brain change www.nature.com/articles/s41...

Google's notebookLM (notebooklm.google) generated this infographic (in ~1 min) about a recent paper: jamanetwork.com/journals/jam...
It isn't perfect, but it is a solid start. It feels like lots of journals' promotions/media departments won't last long with this...

Brain activity explains message effectiveness: A mega-analysis of 16 neuroimaging studies Abstract. Persuasive communication in marketing, political, and health domains influences sales, elections, and public health. We present a mega-analysis (

Brain activity explains message effectiveness: A mega-analysis of 16 neuroimaging studies academic.oup.com/pnasnexus/ar...

Childhood adversity, low positive affect and psychopathology: a meta-analytic structural equation modeling study - Nature Mental Health In this meta-analytic structural equation modeling study, Stoia et al. examined whether positive affect mediates the relationship between childhood adversity and psychopathology.

Childhood adversity, low positive affect and psychopathology: a meta-analytic structural equation modeling study www.nature.com/articles/s44...

COVID-19-Induced School Closures and Disadvantaged Children’s Post-COVID Academic Growth: A Longitudinal Cohort Study edworkingpapers.com/sites/defaul...

Understanding the impact of misinformation on adolescents - Nature Human Behaviour Adolescents are especially vulnerable to misinformation but also possess unique strengths. This Perspective outlines a forward-looking research agenda to understand these vulnerabilities and foster re...

Understanding the impact of misinformation on adolescents www.nature.com/articles/s41...

Human brain R2* transitions across birth from the womb to early infancy - Communications Biology Using 147 MRIs (25–60 weeks), this first longitudinal study of R2* across fetal to neonatal periods shows distinct regional trajectories, with linear and non-linear patterns reflecting iron-related ma...

Human brain R2* transitions across birth from the womb to early infancy www.nature.com/articles/s42...

Age‐Related Changes in the Amygdala From In Utero to Early Childhood: Association With Social and Cognitive Outcomes This study investigates amygdala maturation from the fetal period through early childhood using MRI across six cohorts. Findings revealed sex and hemispheric differences in growth trajectories, with ....

Age-Related Changes in the Amygdala From In Utero to Early Childhood: Association With Social and Cognitive Outcomes onlinelibrary.wiley.com/doi/10.1002/...

How Family Assets and Debts Relate to Children's Achievement and Behavior Problems Across Development Wealth matters for children's academic achievement and behavioral functioning; however, little is known about how the components of wealth, particularly assets and debts, uniquely relate to children'...

How Family Assets and Debts Relate to Children's Achievement and Behavior Problems Across Development onlinelibrary.wiley.com/doi/10.1111/...