Jamie Hanson

Positive Affect as a Developmental Mediator of Early Adversity and Internalizing Psychopathology Early life adversities (ELAs) including experiences such as abuse, neglect, and household dysfunction are strongly linked to psychopathology; yet, the developmental pathways connecting ELA to external...

🆕 RESEARCH: Not all kids respond to early adversity the same way. We examined data from ~7,400 children for 4 years and found something notable about positive emotions & mental health outcomes...
doi.org/10.1101/2025...

A thread 🧵 #MentalHealth #ChildDevelopment #Resilience /1

(same!)

Mapping cerebral blood perfusion and its links to multi-scale brain organization across the human lifespan How does cerebral blood perfusion map onto micro-, meso- and macro-scale brain structure? Using arterial spin labeling data from the Human Connectome Project, this study provides a detailed characteri...

Mapping cerebral blood perfusion and its links to multi-scale brain organization across the human lifespan journals.plos.org/plosbiology/...

Data‐Driven Approach to Dynamic Resting State Functional Connectivity in Post‐Traumatic Stress Disorder: An ENIGMA‐PGC PTSD Study In a large global sample of people with trauma exposure, we utilized a data-driven approach to evaluate resting state brain network dynamics. Neither static nor dynamic functional connectivity dynami....

Data-Driven Approach to Dynamic Resting State Functional Connectivity in Post-Traumatic Stress Disorder: An ENIGMA-PGC PTSD Study...
onlinelibrary.wiley.com/doi/10.1002/...

TLDR: "Neither static FC nor dynamic FC results showed robust differences between groups."

Smartphone Engagement During School Hours Among US Youths This cross-sectional study measures use of smartphones during the school day among US youths.

Smartphone Engagement During School Hours Among US Youths jamanetwork.com/journals/jam...

Yes, we know that childhood adversity impacts emotions in different ways, *BUT* the point is that isn't *all* of those kids. There's ~30% of children & adolescents that we really need to support (and charting differences in their positive moods might be one way to identify those at particular risk).

a man wearing glasses and ear buds is talking in front of a window ALT: a man wearing glasses and ear buds is talking in front of a window

📝 And rather than waiting for mental health problems to emerge, we might focus interventions on supporting positive emotional experiences in at-risk youth. /5

😨 Children in the "persistently low" positive emotion group showed the strongest link between early adversity and later depression/anxiety symptoms. This suggests positive emotional development may be a key mechanism we can target for interventions. /4

🎯 Adversity was linked to all of the non stable positive affect groups. It was rare for a child who experienced a few different adversities to be in the high-stable positive affect group /3

📈 Using advanced trajectory modeling, we identified 4 distinct patterns of positive emotions over time:
🔴 High-Stable (maintained levels)
⚫ Declining (started high, dropped in adolescence)
🟣 Persistently Low (consistently low throughout)
🟢 Volatile (variable patterns) /2

Positive Affect as a Developmental Mediator of Early Adversity and Internalizing Psychopathology Early life adversities (ELAs) including experiences such as abuse, neglect, and household dysfunction are strongly linked to psychopathology; yet, the developmental pathways connecting ELA to external...

🆕 RESEARCH: Not all kids respond to early adversity the same way. We examined data from ~7,400 children for 4 years and found something notable about positive emotions & mental health outcomes...
doi.org/10.1101/2025...

A thread 🧵 #MentalHealth #ChildDevelopment #Resilience /1

a sign that says please donate in red and yellow ALT: a sign that says please donate in red and yellow

I'm fundraising for Project Destiny... and it is a #ONEDAY event (Today!!!! ). Donate or share! Every gift matters!

PD empowers Pittsburgh youth through mentoring, tutoring & mental health support. www.pittsburghgives.org/organization...
cc: @pghfoundation.bsky.social

Integrating and interpreting brain maps www.cell.com/trends/neuro...

Trauma-predictive brain network connectivity adaptively responds to mild acute stress | PNAS Past traumatic experiences shape neural responses to future stress, but the mechanisms underlying this dynamic interaction remain unclear. Here, we...

Trauma-predictive brain network connectivity adaptively responds to mild acute stress www.pnas.org/doi/10.1073/...

General anesthesia in early infancy accelerates visual cortical development www.pnas.org/doi/full/10....

Adolescent depression, childhood maltreatment, and the immune system; a role for epigenetic aging? Childhood maltreatment is a major risk factor for the development of depression, as well as for imbalances in the immune system, including chronic low…

Adolescent depression, childhood maltreatment, and the immune system; a role for epigenetic aging? www.sciencedirect.com/science/arti...

Consensus statement on developmentally appropriate policy and practice for adolescents in foster care Adolescence is a period of important neurobiological, social and cognitive changes. Under optimal conditions, adolescents are supported by parents who…

Consensus statement on developmentally appropriate policy and practice for adolescents in foster care www.sciencedirect.com/science/arti...

Today #NIH leadership were told no funds can go out for research project grants, R&D contracts or training grants.

We have just a couple weeks to get funds out the door before Russel Vought attempts a #PocketRescission on Aug 15.

Even if this ends up being temporary, it’s time we don’t have.

Any #EMA colleague open to chat about different platforms? I was trying to use phone pings in a really specific way and wondered what different vendors could support, etc.

Impact of inflammation on white matter integrity and functional connectivity in chronic major depressive disorder www.sciencedirect.com/science/arti...

Changes in Model-Based and Model-Free Control Prospectively Predict Drinking Trajectories in Young Men Expanding our previous findings that model-based/model-free (MB/MF) control—often conceptualized as goal-directed and habitual behavior—at age 18 is associated with alcohol drinking trajectories over ...

Changes in Model-Based and Model-Free Control Prospectively Predict Drinking Trajectories in Young Men www.biologicalpsychiatryjournal.com/article/S000...

Direct interactions between the human insula and hippocampus during memory encoding www.nature.com/articles/s41...

Challenging the status quo: A guide to open and reproducible neuroimaging for early career researchers direct.mit.edu/imag/article...

DNA methylation profiles of long-term cannabis users in midlife: a comprehensive evaluation of published cannabis-associated methylation markers in a representative cohort www.nature.com/articles/s41...

f/t paid postbac RA position w/ my wonderful friends at Pitt - @jamielarsh.bsky.social - cfopitt.taleo.net/careersectio...

The splendour of unthresholded brain maps apertureneuro.org/article/1406...

Precision psychiatry roadmap: towards a biology-informed framework for mental disorders www.nature.com/articles/s41...

Deconstructing neural predictors of risky choice academic.oup.com/pnasnexus/ad...

Linking pregnancy- and birth-related risk factors to a multivariate fusion of child cortical structure | PNAS Pregnancy- and birth-related factors affect offspring brain development, emphasizing the importance of early life exposures. While most previous st...

Linking pregnancy- and birth-related risk factors to a multivariate fusion of child cortical structure www.pnas.org/doi/10.1073/...

Successful Evidence-Based Parenting Programs are Associated With Brain Changes and Improved Reward Processing in Boys With Conduct Problems www.biologicalpsychiatryjournal.com/article/S000...