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Zilu Ye

@ziluye.bsky.social

Proteomics, Mass Spectrometry. Group leader at Institute of Systems Medicine, Chinese Academy of Medical Sciences.

38 Followers  |  70 Following  |  3 Posts  |  Joined: 25.03.2025  |  2.175

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Together with a dual-spray LC-MS system that doubles analytical efficiency, this workflow bridges high sensitivity with true high throughputβ€”making large-scale single-cell proteomics a reality. Using this integrated platform, we built a mouse tissue single-cell proteome atlas.

06.11.2025 10:05 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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We developed SPRINT, an AI-powered single-cell proteomics (SCP) platform capable of preparing over 10,000 cells per day, more than tenfold faster than existing systems, while maintaining exceptional stability and sensitivity (>6,000 proteins per cell).

06.11.2025 10:05 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0
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End-to-end high-throughput single-cell proteomics via SPRINT and dual-spray LC-MS Single-cell proteomics (SCP) enables direct measurement of protein heterogeneity but remains constrained by throughput and limited applicability to primary tissues. Here, we present an integrated work...

Excited to share our latest work: End-to-end high-throughput single-cell proteomics via SPRINT and dual-spray LC-MS www.biorxiv.org/content/10.1...

06.11.2025 10:05 β€” πŸ‘ 7    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0
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Global analysis of protein turnover dynamics in single cells The SC-pSILAC method enables single-cell measurement of both protein abundance and turnover, providing notable advances in the depth and versatility of proteomic technologies.

πŸš€ Excited to share our latest article in #singlecell proteomics published in Cell!
We've developed SC-pSILAC to simultaneously measure protein turnover and abundance in single cells, unlocking the first large-scale, 2D proteomic insights at single-cell resolution!

www.cell.com/cell/fulltex...

31.03.2025 15:11 β€” πŸ‘ 46    πŸ” 12    πŸ’¬ 2    πŸ“Œ 2

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