Aleyah E. Goins

Excited to announce my thesis paper with is now in print at ELIfe! Excited to share our updated work on automating evoked touch/pain assays in rodents, and the further advancements we’ve made for #PainResearch!

elifesciences.org/reviewed-pre...

small typo: type 1 IFN* not y :)

Cancer-induced nerve injury promotes resistance to anti-PD-1 therapy - PubMed Perineural invasion (PNI) is a well-established factor of poor prognosis in multiple cancer types¹, yet its mechanism remains unclear. Here we provide clinical and mechanistic insights into...

When cancer invades nerves, inflammation pops off and causes pain! Ouch! 😬 Then, IL-6/IFNγ drives resistance to anti-PD-1 cancer treatment, lowers effectiveness 😱. The resistance was reversed by targeting nerve-injury signaling pathways. Critical discovery connecting #PainResearch to immunotherapy!

This work was done at the #NYU #PainResearchCenter.

Perineural Invasion Exhibits Traits of Neurodegeneration - PubMed Perineural invasion (PNI) frequently occurs in head and neck squamous cell carcinoma (HNSCC), which correlates with poor survival and induces intractable pain and numbness. There is no effective treat...

Novel perineural invasion (PNI) mouse model mimics the intractable pain of head & neck cancer in humans 🤯, revealing that cancer-related nerve damage shares features with neurodegeneration. 🧠 Crucial tool for testing future pain treatments! 📈 #NYU #PainResearch #PNI #HNSCC

Next-generation precision medicine for pain - Molecular Psychiatry Molecular Psychiatry - Next-generation precision medicine for pain

A blood test for pain?

New work in Nature identifies circulating biomarkers that distinguish chronic pain states—offering a path toward objective, biologically grounded diagnostics.

#PainResearch #Neuroskyence #Biomarkers #ScienceWatch #SciComm #ScienceInTranslation #ChronicPain

High-speed mapping of whole-mouse peripheral nerves at subcellular resolution In contrast to the rapid advancements in mesoscale connectomic mapping of the mammalian brain, similar mapping of the peripheral nervous system has re…

Incredible! A new imaging system has allowed researchers to map the entire adult mouse peripheral nervous system at micrometer resolution. This is a massive leap in understanding cellular interactions in health and disease. #Neuroscience www.sciencedirect.com/science/arti...

Sage Journals: Discover world-class research Subscription and open access journals from Sage, the world's leading independent academic publisher.

One of our final papers from this collaborative effort involving collaborators at UNM, Mayo Clinic, & McGill. Here we validate a humanized scFv targeting hP2XR. Kudos to first-author @docnessmonster.bsky.social & former lab member Mark S. for making this happen! journals.sagepub.com/doi/10.1177/...

Inhibition of Nonsense-Mediated Decay in Dorsal Root Ganglion Neurons - PubMed Given the unique morphology of neurons with extensive projections, such as nociceptors, mRNA regulation is crucial for their physiological processes and function. Tools for manipulating post-transcrip...

pubmed.ncbi.nlm.nih.gov/40699432/
#PainResearch #NeuroSkyence #Neuron #Neuroscience
Inhibiting mRNA quality control in nociceptors reveals pathways driving chronic pain. Must read!

Grant list for general #ECR postdocs and faculty, with additional dedicated lists for #neuroscience / #neuroskyence and #cancer / #oncology

A huge thank you to @deniswirtz.bsky.social & team for this collection

Assistant Professor, Neurobiology - Reno, Nevada (US) job with University of Nevada, Reno - College of Science | 674336 The Department of Biology at the University of Nevada, Reno, is looking for a tenure-track assistant professor to join us starting July 1, 2026. We...

We are hiring! Tenure-track position in Neurobiology in the Department of Biology at the University of Nevada, Reno @unevadareno.bsky.social. 🧪🧠 #neuroscience #neuroskyence

jobs.sciencecareers.org/job/674336/a...

Poster with white background and four pastel-colored rounded boxes listing books in order: 1) Breaking Through by Katalin Karikó, 2) The Emperor of All Maladies by Siddhartha Mukherjee, 3) The Omnivore’s Dilemma by Michael Pollan, 4) The Dispossessed by Ursula K. Le Guin.

Lately, I've pivoted to reading scientific literature and not books. I'm sad my book review posts have slowed down because of this. So I'm going to post my to-be-read book list before 2026 instead... #BookSky #ScienceLiterature #NonFiction

🧪 Philadelphia area Neuroscientists: This is a great opportunity to meet other area neuroscientists and share your work as a speaker (postdoctoral fellow) or with a poster (anyone with data!) www.spinephilly.org #neuroscience #Philadelphia #neuroskyence 🧠

One of the Astronauts from the golden era 🧑‍🚀 passing is news that stirs up the calling to reach above and beyond. Honored to have been alive at the same time as these talented individuals. 🙌

Like my mama always said “nothing is as it seems”, “it could be better than you think” 🤔 🌈
The meditation tonight is to sit deep in anxiety, look around the room and observe the chaos inside, it could be the most insightful and fruitful experience yet. 😘 #BlueSky #HOPE #Hallelujah

20 minute walks. 🦋👩‍🍳💋

Thanks for the highlight of our recent work! #PainResearch @painresforum.bsky.social
painresearchforum.org/paper/expres...

Neuro-immune crosstalk in cancer: mechanisms and therapeutic implications - Signal Transduction and Targeted Therapy Signal Transduction and Targeted Therapy - Neuro-immune crosstalk in cancer: mechanisms and therapeutic implications

This review has been bothering me. Organ innervation leads to pain modulation depending if sympathetic or parasympathetic systems are activated which downstream affects tumor growth?! Rest and digest, rest and digest, rest and digest… #pain #cancer #neuroscience www.nature.com/articles/s41...

#TourDeFrance ended today and it was a wild ride! #Tadej won the triple crown better than Secretariat, despite stages planned to exploit his weaknesses. Well that’s just a rumor but still goes to show you he won against all odds! #Victory #Pogacar #Cycling

#BookSky #Space #Exploration #MichaelCollins #CarryingTheFire #Inspirational

The cover of Carrying the Fire: An Astronaut’s Journeys by Michael Collins shows a vivid, cloudless blue sky as the background. At the top, the title is centered in large white uppercase letters: CARRYING THE FIRE. Beneath that, in a smaller yellow or white font, it reads An Astronaut’s Journeys. At the bottom or across part of the image appears the author’s name in a clean, sans-serif style: MICHAEL COLLINS. Some editions include a photograph of Collins in his spacesuit or a background image of a rocket launch, adding a human and aspirational touch.

Summer 2025✨, I read Carrying the Fire by Michael Collins. Favorite book this year. Have you ever wondered about the third guy on Apollo 11? Did you know there was a third guy? I learned so much about space and organizational leadership from down-to-earth descriptions. So easy to consume ravenously!

Colored droplets in corn syrup seemingly blended together can be returned to their original state by reversing the direction of mixing, a form of laminar flow called "Stokes flow".

Credit: UNM Physics & Astronomy

Cool! Happy hiring 🤩

Amazing score! Best of luck 😻

Macrophages amplify the spontaneous activity of damaged sensory neurons in a human co-culture model of neuropathic pain Neuropathic pain is a highly prevalent condition for which treatments are hampered by low efficacy and dose-limiting side-effects. Injury to the somatosensory nervous system causes maladaptive plastic...

New preprint out now describing how macrophages can amplify spontaneous activity of damaged sensory neurons in a humanised in vitro model www.biorxiv.org/content/10.1...

Associations of Pain, Anxiety, and Depressive Symptoms With Sleep Outcomes in Patients With Head and Neck Squamous Cell Carcinoma: A Cross‐Sectional Observational Study Background This exploratory cross-sectional observational study sought to characterize sleep quality and evaluate its association with sociodemographic, clinicopathological, behavioral, and psycholo...

A new study with Dr. Yi Ye as a co-author "Associations of Pain, Anxiety, and Depressive Symptoms With Sleep Outcomes in Patients with Head and Neck Squamous Cell Carcinoma: A Cross-Sectional Observational Study" #Pain #Anxiety #Depression #HNSCC onlinelibrary.wiley.com/doi/full/10....

#PainResearch 🤗

#BookSky #Theology #Library #ReadingList
Odd that my public library system does not carry any books by Abraham Joshua Heschel. What gives? …anyone care to lend a copy?

Human pain neuroscience and the next generation of pain therapeutics The recent approval of suzetrigine for acute pain treatment highlights both the success of targeting peripheral sensory neurons for pain management and the potential of developing new pain therapies p...

We wrote this Neuroview to get the word out about the extremely exciting and important NIH funded work happening in the pain field and how it has the potential to really change pain treatment in the coming years www.cell.com/neuron/fullt... We did not imagine how rapidly things would be dismantled.

#BookSky #Capitalism #CatherineBracy #WorldEaters #GoodRead