Clem Bernard

Distinct roles for MNK1 and MNK2 in social and cognitive behavior through kinase-specific regulation of the synaptic proteome and phosphoproteome - Molecular Psychiatry Molecular Psychiatry - Distinct roles for MNK1 and MNK2 in social and cognitive behavior through kinase-specific regulation of the synaptic proteome and phosphoproteome

Happy to share the first paper from the lab, now out in Molecular Psychiatry! This was really a collaborative effort from a fantastic team, including key contributions from @dariabunina.bsky.social and @landthalerm.bsky.social
doi.org/10.1038/s413...

Exeter rising-star @hiwwright.bsky.social leading the way in bridging population-scale WGS datasets for federated meta-conditioning across genetically-inferred ancestries. Haplotype effects are rife across the chromosomes: reference panels and LD matrices struggle with the rarest of variation!

We are recruiting a postdoc to join a Wellcome Trust-funded project at LSI-Exeter, investigating the role of neural-pancreas dynamics in maintaining glucose homeostasis. 🐟🔬🧠
@lsiexeter.bsky.social #zebrafish #islet #postdocjobs

jobs.exeter.ac.uk/hrpr_webrecr...

Please repost 🙏

Fin-ally together: the first UK zebrafish meeting Summary: The inaugural UK Zebrafish Meeting 2025 brought together over 150 UK researchers to share scientific advances and discuss strategies for strengthening the national zebrafish research communit...

To keep up the momentum in strengthening our UK #zebrafish community, ECRs at @lsiexeter.bsky.social prepared this meeting review of #UKZF2025 🐟
journals.biologists.com/bio/article/...

PhD studentship: Building Brain Cir | University of Exeter The University of Exeter’s Department of Clinical and Biomedical Sciences is inviting applications for a faculty-funded PhD studentship to commence on September 21st 2026 or as soon as possible therea...

📣 Funded PhD studentship in developmental neuroscience in my lab @exeter.ac.uk 🧠🧑‍🎓

Join us to decode RNA processing in developing mammalian cortical circuits! All info + apply 👉 www.exeter.ac.uk/study/fundin...

⏳Deadline: 28th Feb 2026 | Please share!

#PhD #Neuroscience #Neurodevelopment #RNASky

Subcellular depletion of importin β1 impairs presynaptic local translation and spatial memory Axonal localization of importin β1 is required for presynaptic functions that support spatial memory tasks.

Very happy to share our new paper in #ScienceSignaling revealing that importin β1 isn’t just important for nuclear transport or neuronal growth.

We now show it is key for presynaptic plasticity in the hippocampus, local translation, and memory!

www.science.org/doi/10.1126/...

European Synapse Meeting 2026 21-23 October 2026, Leuven, Belgium Supported by VIB Training & Conferences

Announcing the 10th edition of the European Synapse Meeting in Leuven, October 21-23, 2026. Registration will open soon. Hope to see you all in Leuven this fall! All info: www.vibconferences.be/events/europ...

If you’re looking for a great PhD opportunity on 🧠 development and a top-notch supervisor, look no further than Giselle’s project! 👇🏻

In preprints: the deep evolutionary roots of Cajal-Retzius cells Vertebrates show a striking diversity of brain size and morphology. Mammals, in particular, have an especially large cerebral cortex, presenting with a characteristic six-layered structure that is bel...

We're happy to highlight two very exciting preprints from @idoiaeu.bsky.social and @matosches.bsky.social about the evolution of Cajal-Retzius cells. Find our perspective in @dev-journal.bsky.social here:
doi.org/10.1242/dev....

For those working in psychiatric genomics and related disciplines: join us next Wednesday as we discuss accurate and trusted science communication.

I will cover how researchers can get involved in lending their expertise to educate and combat misinformation, and introduce @authentisci.bsky.social.

Lots of exciting PhD projects available through @swbiodtp.bsky.social

If you are interested in our project using stem cells, CRISPR and genomics, please get in touch. Informal inquiries encouraged

Project:
www.swbio.ac.uk/files/2025/1...

Multiple BBSRC funded PhD projects available via SWBio

with Paul Chadderton looking at cerebellum bpb-eu-w2.wpmucdn.com/blogs.bristo...

with Denize Atan, Zaf Bashir Marc Goodfellow & Mike Ashby
bpb-eu-w2.wpmucdn.com/blogs.bristo...

Please get in touch if you are interested in either project.

📣 We're hiring a postdoc to join our growing team @exeter.ac.uk!
Love developmental neurobiology, RNA regulation & cortical circuits? This might be for you 🧑‍🔬
Apply here 👉 tinyurl.com/2d659uj7
Please share!

I am thrilled to share our latest story led by the incredibly talented Brooke D’Arcy and Camila Musso. We discover a rich world of local gene expression in radial glia, essential neural and glial precursors, and develop a new method for sub-cellular mRNA manipulation. www.biorxiv.org/content/10.1...

We have a fully funded PhD studentship exploring glial cell development with techniques ranging from molecular neuroscience to system biology.

tinyurl.com/2jxezabw

Come and join our interdisciplinary team with Ruth Williams and Beatriz Bano Otalaro

#multiomics
#singlecell
#physiology

Interested in the mechanisms of neurogenesis, and how they might converge/differ across species, regions, and life epochs? Check this out, wonderful location and great science! Please RT

neuro-unige.ch/news/csf-mee...

WTI Postdoctoral Fellowship applications are open! Unique opportunity for those pivoting fields or working across disciplines. I’d be happy to support candidates with a background in immunology and/or in vivo 2-photon imaging, including collaborations with other WTI labs wti.yale.edu/initiatives/...

Research Associate - Project Manager - Brain Organoid Platform | King's College London

We are recruiting for a Research Associate / Project Manager to help us build and run a Brain Organoid Platform at King’s College London, as part of the UK Human Functional Genomics Neurodevelopment Cluster! www.kcl.ac.uk/jobs/125125-...

Local translation of circular RNAs is required for synaptic activity and memory Circular RNAs (circRNAs) are enriched in synapses and implicated in cognitive processes, and recent studies have shown that circRNAs can encode micropeptides, which suggests that there may be novel sy...

How do neurons deal with fitting large regulatory proteins into small spaces to control plasticity and memory? By generating micropeptides via local translation of circRNAs, of course! Here’s to shedding new light on the ‘dark’ proteome in the brain.

www.biorxiv.org/cgi/content/...

Cell-extrinsic controls over neocortical neuron fate and diversity Cell-extrinsic cues are key for neocortical cell identity and diversity.

Ever wondered how robust cellular identity is to external perturbations? Here we disrupt cellular environmnent in vivo and in vitro, and find cell population specific sensitivities. Environment sculpts development yes, but not all cells are made of the same wood. www.science.org/doi/10.1126/...

GABAergic circuits reflect different requirements for sensory integration in postnatal mouse neocortex Information transfer in mammalian cerebral cortex is dependent on GABAergic interneuron circuits that are widely assumed to be uniform across the neoc…

A rather 'unique' paper from our lab is online in @cp-cellreports.bsky.social now. Unique in the sense that I don't think anyone else will be rushing to optotag cortical interneurons in the early postnatal brain... because it is nigh on impossible!

www.sciencedirect.com/science/arti...

The Yang and Phillips labs have an exciting GW4 MRC BioMed DTP PhD project on beta-cell regeneration & designing new proteins with AI tools to control neural signals. Come join us at LSI-Exeter!
gw4biomed.ac.uk/regenerating...
@proteinmotion.bsky.social @lsiexeter.bsky.social #zebrafish #islet

Drawing of a pyramidal cell, interneuron and microglia in a Polaroid.

It was a pleasure writing this Perspective of our work. If you are interested in learning more about activity-dependent regulation of cortical cell numbers, do have a read.

tinyurl.com/4ede4jyb

Hello #Drosophila & #insect people!
I am searching for libraries of ORF/RNA from Tribolium castaneum and Bombyx mori for cloning cDNA/proteins (or insects with unusual body plans).
Is there an existing resource centre where I can find them, please?
Thanks very much in advance for your help!

Please share!
PhD projects available through @gw4biomeddtp.bsky.social
Please get in touch if you are interested in studying chromatin biology in stem cell models

gw4biomed.ac.uk/architects-o...

gw4biomed.ac.uk/risk-vs-prot...

gw4biomed.ac.uk/rna-dependen...

gw4biomed.ac.uk/investigatin...

We are recruiting an enthusiastic engineer to work on the core project of our lab: identifying Hox protein-RNA networks in Drosophila
@igmm-montpel.bsky.social

Interested in BioID, UV-RIP and muscle development? Apply: emploi.cnrs.fr/Offres/CDD/U...

Please share! #jobOffer #RNA #hox #Drosophila

Novel environment exposure drives temporally defined and region-specific chromatin accessibility and gene expression changes in the hippocampus - Nature Communications Hippocampal neurons adapt to experience through changes in gene expression and chromatin accessibility. Here, authors show that novel environment exposure induces region- and cell-type specific transc...

Extremely excited to share the outcome of a fantastic collaboration with @erinduffyphd.bsky.social revealing how experiences reshape hippocamapl chromatin and gene expression.
Check out our searchable gene database and look up your favorite gene 🧬

www.nature.com/articles/s41...

French only: article vulgarisé de nos premiers travaux d'équipe @igmm-montpel.bsky.social @wxiang007c.bsky.social #RNA #Hox #muscle
Merci pour votre soutien a notre recherche fondamentale 🙏 @afm-telethon.bsky.social @agencerecherche.bsky.social

Choroid plexus sex differences in secretory signalling and immune compartments The choroid plexus (ChP)- cerebrospinal fluid (CSF) axis is emerging as a key regulator of the brain environment. The ChP is a multi-functional structure, which forms the blood-CSF barrier, and acts a...

New pre-print on sex differences in the choroid plexus- the 🧠's fluid secretion organ. Important differences in secretory signaling & immune compartments that can impact the 🧠 in health & disease. ‪@karol-kaiser.bsky.social‬@violesilvar.bsky.social‬ Luca von Allmen. 🧪
www.biorxiv.org/content/10.1...