Maria Felicita Gonzalez

Timing may be key to effective cancer treatments Researchers at Washington University in St. Louis find the timing of biopsy can affect how doctors diagnose tumors and when those cancers may be more sensitive to chemotherapy.

Dosing on the way down improves outcomes for glioblastoma. Thanks Maddy Frank for covering this collaboration with @oliviawalch.bsky.social and WashU grad student @mariafelicita.bsky.social. #chronotherapy #circadian #medicine source.washu.edu/2025/11/timi...

21.11.2025 17:34 — 👍 9    🔁 3    💬 0    📌 0

Circadian variation in MGMT promoter methylation and expression predicts sensitivity to temozolomide in glioblastoma - Journal of Neuro-Oncology Purpose Recent studies show that glioblastoma (GBM) is more sensitive to temozolomide (TMZ) in the morning. In cells, inhibiting O6-Methylguanine-DNA-Methyltransferase (MGMT) abolished time-dependent ...

#Circadian #medicine tests if treatment timing can improve patient outcomes. This paper by @mariafelicita.bsky.social @oliviawalch.bsky.social et al considers #chronodiagnostics ...how the outcome of a standard test for glioblastoma differs with time of biopsy. link.springer.com/article/10.1...

22.10.2025 13:04 — 👍 11    🔁 8    💬 0    📌 1

I see two Wash U neuro superstars in this lineup! Shout out to #cancerneuroscience futurists @mariafelicita.bsky.social and Sofi Salvatore Lannes.

14.03.2025 01:26 — 👍 6    🔁 1    💬 0    📌 0

Inspired by artist Tauber-Arb and the discoveries of @mariafelicita.bsky.social, @oliviawalch.bsky.social made this to show how brain cancers grow in response to morning hormonal signals. What do you see?

15.01.2025 09:28 — 👍 19    🔁 6    💬 1    📌 0

Our inaugural issue of 2025 is now live. Read our content for January here: www.cell.com/cancer-cell/...

13.01.2025 18:30 — 👍 7    🔁 3    💬 0    📌 0

Daily glucocorticoids promote glioblastoma growth and circadian synchrony to the host Gonzalez-Aponte et al. identify daily glucocorticoid receptor signaling as an intrinsic driver of glioblastoma (GBM) progression and a synchronizer of tumor clock gene expression to the host. This work provides an intrinsic circadian driver, and therapeutic target, to slow GBM growth, and offers considerations for glucocorticoid use in the clinic.

Excited to share our latest article! We find that the brain tumor Glioblastoma has a circadian clock that syncs with its host’s environment. These tumors also hijack the circadian clock and use daily signals, like glucocorticoids, to grow 🧠⏱️ @erikherzog.bsky.social
More: www.cell.com/cancer-cell/...

12.12.2024 16:48 — 👍 25    🔁 11    💬 0    📌 2

If you just moved to BlueSky and interested in #chronobiology, find some of your community here!

Want to be added? Reply with evidence your work relates to chronobiology.

go.bsky.app/Sw8L4aS

With all the new people coming over, I’ll repost weekly for the next month or so.

🧪 🌍 🦑 #EvoBio

25.11.2024 16:33 — 👍 21    🔁 10    💬 14    📌 0

Circadian regulation of MGMT expression and promoter methylation underlies daily rhythms in TMZ sensitivity in glioblastoma - Journal of Neuro-Oncology Background Glioblastoma (GBM) is the most common primary brain tumor in adults. Despite extensive research and clinical trials, median survival post-treatment remains at 15 months. Thus, all opportuni...

Hi! Could you add me please?

link.springer.com/article/10.1...

25.11.2024 19:18 — 👍 1    🔁 0    💬 1    📌 0

Want to join of a community of Latinx/a/o Scholars broadly throughout academia?
Please reply to this post if you want to be added!! Shout out to @larrylafountain.bsky.social for bringing us together!

go.bsky.app/NrJs1Hr

14.11.2024 04:57 — 👍 135    🔁 100    💬 93    📌 4

Hi! I’d like to be added. Thanks!

25.11.2024 18:58 — 👍 1    🔁 0    💬 1    📌 0

The best part of doing fieldwork in the tropical rainforest is waking up to views like this—lush, endless greens framed by the quiet of nature. Every glance out the window and every walk through the night reminds me why this ecosystem is so special and worth studying.
#herps #Colombia

23.11.2024 20:18 — 👍 18    🔁 1    💬 2    📌 0

First time presenting at #sno2024. Excited to learn about the fascinating new discoveries in #cancerneuroscience (and here’s me bringing a circadian biology twist⏱️🧠)! @neuroonc.bsky.social

23.11.2024 18:21 — 👍 14    🔁 2    💬 0    📌 0

Only 1 percent of neuroscience faculty is Black. Kaela Singleton hopes to change that. Whatever you do, don’t call the Black in Neuro founder “resilient.”

"my least favorite thing in life is to be called “resilient,” bc it means that people only see me through the lens of difficulty. They love the idea that I am resilient, but they don’t actually care about any of the things that made me resilient."
@kss_phd www.vox.com/future-perfe...

22.11.2024 16:24 — 👍 124    🔁 41    💬 5    📌 4

Extremely cool insights into circadian medicine for glioblastoma from Maria Gonzalez-Aponte, Erik Herzog, and their collaborators: pubmed.ncbi.nlm.nih.gov/38277015/

20.11.2024 14:44 — 👍 7    🔁 3    💬 0    📌 0

How I think about circadian entrainment (+sleep as a rhythm that can have or lack a groove)

21.11.2024 17:09 — 👍 3    🔁 1    💬 0    📌 0

Here’s a little bit of what we do. Timing is everything. We recently discovered that chemo for Glioblastoma, a deadly brain tumor, can be enhanced by delivering it in the morning. These tumors know the time of day, and we can use it to improve treatment. Read more: pubmed.ncbi.nlm.nih.gov/38277015/

21.11.2024 20:57 — 👍 6    🔁 3    💬 0    📌 0

Hola Bluesky! Quick intro: I recently completed my PhD in Neuroscience at WashU, and I’m now a postdoc in the Herzog lab studying the interactions between brain cancer and circadian biology. Beyond the bench, I love teaching, mentoring, and creating spaces for historically excluded communities.

21.11.2024 20:38 — 👍 16    🔁 4    💬 1    📌 0