ZK

And I say this as someone who is as UF and is inclined to support findings spearheaded from here.

@sciencevs.bsky.social have enjoyed the show over the years, but I have to be honest to say I was pretty disappointed at the lack of methodological critiques of fluoride cohort studies. Even a cursory reading identify clear, significant limitations.

Immune evasion through mitochondrial transfer in the tumour microenvironment - Nature Mitochondria with mutations in their DNA from cancer cells can be transferred to T cells in the tumour microenvironment, which leads to T cell dysfunction and impaired antitumour immunity.

This publication in Nature was fascinating: Cancer cells swap mutated mitochondria with tumor-infiltrating immune cells (TILs). Metabolism is the keystone of cancer immunotherapy, yet often overlooked. Could this mechanism provide clues to increasing patient response? www.nature.com/articles/s41...

We are going to need them because at this rate no one will be able to retire (or afford child care or health care or elder care or a house or a car or food).

So much winning!

Eastern markets are having none of it.

Anti-Trump Protests Get Underway Across the Country Demonstrators packed the streets in cities and towns to rail against government cutbacks, financial turmoil and what they viewed as attacks on democracy.

Were all couple hundred thousand protestors Soros plants, then? Elon? Right wing grift-o-sphere?

www.nytimes.com/2025/04/05/u...

ProPublica's 2024 Annual Report ProPublica is an independent, non-profit newsroom that produces investigative journalism in the public interest.

I'm proud to share ProPublica's 2024 annual report. Being transparent about our work and its impact in the world is one of the things I like most about working here. Hope you'll give this a look:

ICYMI — SENATOR BOOKER: “I rise to disrupt the business of the senate for as long as I am physically able… because I believe sincerely our country is in crisis.” 🇺🇸

🐊🐊🐊🐊🐊

Makes me wonder why I’m working on a Saturday.

Well there it is

Brokerage accounts *are* free. Kinda shot myself in the foot there.

The min balance on many basic checking accounts in $50-100. Opening a brokerage account is not free, and even fraction shares of SPDR or QQQ are available. What are you talking about?

A transformative platform will be delayed by what? A decade? 2 decades? All because of political valence. Tragic.

At a population level, it would correlate. In terms of trying to establish an exposure-outcome relationship… 😬😬

Also, fwiw, “brain lesions” via spot MRI as a measure of dementia trajectory is… not great.

And yet its impact on hard endpoints in humans has been… underwhelming.

@profgalloway.com I’m not sure equating Steve Bannon to AOC is the equivalency you want to posit to make your “crossing enemy lines” point.

The working experiment is to see if selection of an UPF and its corresponding dopamine response in ventral striatum corresponds to adiposity and or ad libitum weight trajectory/food consumption.

Exciting times! Counting on you to keep leading the field.

@zknight.bsky.social ‘s work in this is probably the most informative in the pre-clinical space, but how that then translates into easy access UPFs in mice/rats and humans (and how to study) is what I want to make sure to study with precision.

And if it doesn’t translate, it’s important to know

My bias is viewing especially human obesity as having biopsychosocial elements, so whether intermediate-term signals mirror bite-to-bite impacts is something I still struggle with.

No argument, was just speaking on the work i and some collaborators are doing now. I’m trying to continue to equilibrate of persistent and reliable increases in rodents, regionality (ventral vs dorsal striatum vs orbitofrontal can represent some meaningfully different neurocircuitry).

Now I’m wondering if we should modify to look at dopamine over much longer timescales? Is this better reflective of chronic dopamine dynamics between individuals? Or does it just not translate from rodents to humans?

Great work by you and your team (shoutout Dr. Darcey).

It clarifies but also raises some questions. In pre-clinical models, we do see some variance in ventral striatal dopamine response to palatable food, but its moment-to-moment measures.

Apparently we are aiming to take no steps forward and all the steps back.

That is… devastating.

Wait, Eric Berg is part of their “team”???

…and there it is.

Doesn’t understand the science. Appeal to nature and/or accusation of bias strategy.

This place is more like Twitter than I thought. Bummer.

Disqualifying to the argued extrapolation.

This is a shame, but not something I can remedy for you. I’ve learned from my Twitter days that trying for protracted thread’s worth of time is a poor use of time.

Did you actually look up the studies they are suggesting are supportive of this argument? If you did and you bring this as evidence, then we can probably move on.

It appears quite clear that you aren’t grasping why the lack of persistence of the proposed mechanism to humans is entirely…