Karla Feijs-Žaja

A general rather than site- & function-specific role for protein modification by ADP-ribosylation?
@kfeijszaja.bsky.social , Roko Zaja and coworkers find that labeling by #PARP7 facilitates ubiquitin-dependent degradation of multiple targets upon proteotoxic stress
www.embopress.org/doi/full/10....

Job alert! We are recruiting a postdoc to study a novel RNA modification: ADP-ribose.

🔬Do you have experience working with RNA? Are you eager to explore new frontiers in RNA biology? Join our team and help uncover the secrets of RNA ADP-ribosylation: adpribosylationlab.wordpress.com/2025/10/28/p...

🎯 𝐒𝐭𝐫𝐚𝐭𝐞𝐠𝐢𝐜 𝐏𝐥𝐚𝐧𝐧𝐢𝐧𝐠 𝐟𝐨𝐫 𝐘𝐨𝐮𝐫 𝐑𝐞𝐬𝐞𝐚𝐫𝐜𝐡 𝐂𝐚𝐫𝐞𝐞𝐫 – 𝐉𝐨𝐢𝐧 𝐔𝐬!
📅 Workshop Details (Limited to 8 participants)
𝐃𝐚𝐭𝐞: January 20, 2026 (online)
𝐀𝐩𝐩𝐥𝐢𝐜𝐚𝐭𝐢𝐨𝐧 𝐃𝐞𝐚𝐝𝐥𝐢𝐧𝐞: November 1, 2025
Led by: Dr. Beate Scholz (Scholz CTC GmbH)
Not a member of the GBM-YI? You can register here: gbm-online.de/de/young-inv...

Seeing how I always comment on train connections when traveling in Germany... My train is on time 🎉 Which means I'll be arriving an hour and a half early 😅 See you later at the @gbmev.bsky.social GBM Compact Meeting in Frankfurt!

I remember the reviewer who once said our manuscript is "a cornucopia of mistakes". That was really helpful indeed 😐

I'm grateful for Nonso's hard work on this project, Jörg's assistance with autophagy, Bernhards' hosting of our little group and the excellent teamwork with Roko.

The reviewers and editor from the Journal have also been great to shape the revisions and make the paper better.

Thank you all 🙏

Do other PARPs label substrates for degradation as well? In which conditions is this most relevant? How do ADP-ribose and ubiquitin connect to regulate degradation?

This is a very exciting finding, as it connect well with several recent publications that indicate that proteins modified by PARP7 are degraded. For example: doi.org/10.1016/j.ce...
doi.org/0.1038/s4431...
doi.org/10.1101/2025...

It also leaves many questions to be answered in future:

PARP7 is a proteotoxic stress sensor that labels proteins for degradation | The EMBO Journal imageimageADP-ribosylation is thought to occur on specific sites to affect specific characteristics of target proteins. Here, it is found to play a more promiscuous role, with PARP7 labelling proteins for efficient degradation during proteotoxic ...

I'm very excited to be able to share the latest work from our group with you:

doi.org/10.1038/s443...

We find that PARP7 is stabilised following proteotoxic stress and ADP-ribosylates proteins to enable their degradation. This occurs in a ubiquitin-dependent manner.

The advantage of having a Croatian husband, is that you can find beautiful spots to spend some time away from everything 😏

Perhaps Midnight Library by Matt Haig?

Upcoming Event: "From Academia to Industry – Working at Novo Nordisk A/S"
📅 Date: August 21, 2025
🕟 Time: 4:30 p.m.
🎤 Speaker: Dr. Martin Peter
🔗 Register here: gbm-online.de/de/nachwuchs...
Zoom link will be sent to registered participants.
Please share with your postdoc colleagues!

The Biochemical Society 2027 Awards. Our 2027 Awards are now open for nominations! Deadline 3 November 2025

Nominations are now open for the 2027 Awards! With 12 categories spanning all career stages, there's never been a better time to recognise the outstanding work of your colleagues. Visit our website to find out how to nominate #BiochemAwards buff.ly/FHTSGz8

Ozzy Osbourne being Ozzy Osbourne.

An incomparable legend.

Figure 2. Overview of N6-methyladenosine (m6A) decay pathways. m6A acts as a destabilizing mark on mRNA.

"m6A in the coding sequence: linking deposition, translation and decay"
by Kathi Zarnack (@zarnack-group.bsky.social) & colleagues

"This review explores [m6A in] mRNA decay, with a focus on the newly discovered CDS–m6A decay (CMD) pathway..."

Read it here:
authors.elsevier.com/sd/article/S...

Neil young and the Chrome hearts on stage. Background text love earth

Almost 80 but what an energy - Neil Young! I am so grateful to have seen him play with the Chrome Hearts yesterday 🤩 Rock 'n' roll will never die...

Have your say...

Enter our essay competition and win £250. Share with us your ideas on how to innovate event organisation to have a lower environmental impact.

Entry deadline: Friday 20 June

Enter now: www.biologists.com/stories/essa...

#Innovation #Sustainability #Environment

Q for the hive-mind 🧠: What transfection reagents do people like for big constructs these days? (I am thinking #HSV encoding BACs, ~170 kb). We've recently had poor performance with Trans-IT LT1 and Lipofectamine 2000, our two go-tos. Target cells are U2OS. Suggestions or RTs greatly appreciated 🙏

Autophagy-lysosome pathways are known targets of intracellular bacteria – Ivan Đikić @idikic.bsky.social et al find Legionella uses phosphoribosyl-ubiquitination via SidE to alter autophagic SNAREs & create a bacteria-containing vacuole unable to fuse with lysosomes
www.embopress.org/doi/full/10....

Registration is OPEN for the 28th Signal Transduction Society Meeting—first-ever #CellCommSummit!
🗓️ November 3–5, 2025, Leonardo Hotel, Weimar
Join us for talks, poster sessions, and networking. Travel grants for young researchers available.
🔗 www.sigtrans.de
#SignalTransduction #CellCommSummit

How a discovery in Yellowstone National Park led to the development of PCR - Richmond Scientific A discovery in Yellowstone National Park led to the development of PCR, the gold-standard COVID-19 tests used to fight the global pandemic.

Reminder: Nobel-prize winning PCR (1983), used in basically all genetic tech today, was only possible because of extremophile bacterium discovered in 1964 in Yellowstone funded by a small ~$80k NSF grant with no obvious application at the time. #science 🧪
www.richmondscientific.com/how-a-discov...

We're hiring! The Journal of Cell Biology (JCB) seeks Scientific Editor or Senior Scientific Editor, dependent on experience. Join our team in New York City! Apply here 👉 careers.rockefeller.edu/jobs?keyword...

#STEMjobs #LifeScienceJobs #PublishingJobs #ScienceJobs

The newest addition to my board game collection just arrived 🤩 Need a game night soon then 😁 #publishorperish

🏆 𝐑𝐨𝐥𝐚𝐧𝐝 𝐒𝐜𝐡𝐚𝐮𝐞𝐫 𝐍𝐚𝐜𝐡𝐰𝐮𝐜𝐡𝐬𝐩𝐫𝐞𝐢𝐬: Deadline bis 30.06.2025 verlängert! 2.000 € für exzellente Forschung in #Glykobiologie. Bewerben können sich junge Wissenschaftler:innen. Infos & Bewerbung: awards@gbm-online.de und gbm-online.de/en/news-even... #Nachwuchsförderung #GBM

Interested in doing a postdoc in Germany, on a topic involving ADP-ribosylation of proteins or RNA? Or even the novel dual modification with ubiquitin attached to proteins via ADP-ribose?? If yes ➡️ do get in touch 😊

Calling all last-minute legends!
The formal deadline to apply for the GMI GLs call is tomorrow—so there’s still time to make it look like you planned this all along 😉

Another awesome collaboration with @jnpruneda.bsky.social and team providing deeper insight into the writers of MARUbylation. Check out thread 👇!

I recently rediscovered Terry Pratchett. The little nuggets of wisdom sprinkled throughout his works are amazing. I do appreciate them much more these days then when first reading Pratchett 20 years ago...

The Professional Self: The Enemy Inside

I'd like to share this short piece on a topic I hope you will find useful. It is the result of a personl journey and many discussions with friends and peers. Let me know your thoughts.

network.febs.org/posts/the-pr...

Only one week to go to the PARP meeting in Strasbourg! It's the first meeting that both me and my husband will attend! Usually one of us is stuck at home with the kids... And even better - we're both planning to show some new stuff 🤩