Anete Patrīcija

Acridinium Photocatalyzed Monofluoromethyl Radical Cascade Reaction of Alkenes with Iodine(III) Reagent: A Mechanistic Study Acridinium salts are effective organic photoredox catalysts with strong oxidizing properties, but their potential as photoreductants in photocatalysis is underexplored. This study investigates their ....

✨ New paper out in Advanced Synthesis & Catalysis!
See how we access monofluoromethyl oxindoles by using acridinium salts as photoreductants.

Thanks to all collaborators & my supervisors @RamKumar9687 @j_veliks.
A great finale to my time in Veliks Lab!

Monofluoromethyl Radical Mediated Halogen-Atom Transfer Halogen-atom transfer (XAT) is an effective method for generating carbon radicals from alkyl halides. While stannanes and silanes have shown potential, their toxicity and secondary reactivity necessitate the search for better alternatives. Recently, carbon-based α-amino alkyl radicals have emerged as possible substitutes; however, their generation under photochemical conditions requires the use of photocatalysts. In this work, we present a novel XAT method that eliminates the need for photocatalysts by utilizing the direct excitation of a monofluoroacetoxy ligand-containing hypervalent iodine(III) reagent. This approach allows nucleophilic monofluoromethyl radicals to efficiently form carbon radicals from activated alkyl halides. These radicals can subsequently functionalize unactivated alkenes through atom transfer radical addition (ATRA). Our mechanistic studies provide insights into the generation of monofluoromethyl radical and its unique reactivity. This work highlights the untapped potential of simple, single carbon atom-containing radicals for effective alkyl radical generation.

Excited to share that my first publication is now online in @jacs.acspublications.org! 🎉 Check it out to learn more about the monofluoromethyl radical and its ability to act as a halogen-atom transfer reagent. Many thanks to Dr. Janis Veliks and Dr. Nagarajan Ramkumar!
pubs.acs.org/doi/10.1021/...

I’ve successfully defended my Master’s thesis at the University of Latvia! 🎓 Our work explores CH2F radicals as XAT reagents. Check out the preprint - bit.ly/43L7lJz
Huge thanks to supervisors Dr. Ram Kumar Nagarajan and Dr. Janis Veliks!
On to the next chapter! 🏔️✨

#Chemistry #Latvia #MSc

Grateful to have received the Mundheim Family Excellence Scholarship from the University of Latvia Foundation. 🙏🏼✨ Thank you for the support — looking forward to continuing my studies and research in organic synthesis. 🧪

#Grateful #Scholarship #UniversityOfLatvia