Markus Landthaler

Dynamic RNA Polymerase compartments organize the transcription of gene clusters https://www.biorxiv.org/content/10.64898/2026.01.07.698080v1

bioRxiv

Meeting @mdc-berlin.bsky.social alumni: Yongbo Wang (Fudan U), @munschauerlab.bsky.social (Heidelberg U), and Wei Chen (SUSTech) at Sino-German RNA Symposium in Shenzhen

The DND1-NANOS3 complex shapes the primordial germ cell transcriptome via a heptanucleotide sequence in mRNA 3'UTRs The RNA-binding proteins DND1 and NANOS3 are essential for primordial germ cell survival. Their co-immunoprecipitation and overlapping loss-of-function phenotypes suggest joint function, yet how they ...

www.biorxiv.org/content/10.1...

Collective homeostasis of condensation-prone proteins via their mRNAs - Nature The authors discover a homeostatic process termed interstasis, in which an increased concentration of proteins within RNA–protein condensates induces the sequestration of their own mRNAs.

www.nature.com/articles/s41...

Rapid UPF1 depletion illuminates the temporal dynamics of the NMD-regulated human transcriptome UPF1 depletion inhibits nonsense-mediated mRNA decay (NMD) and stabilizes direct target transcripts within hours. Boehm et al. use conditional protein degradation and advanced transcriptomics to map t...

Very harmonious and inspiring collaboration with Niels Gehring, @volkerboehm.bsky.social and team at Uni Köln, and colleagues at @mdc-berlin.bsky.social . Rapid UPF1 depletion illuminates the temporal dynamics of the NMD-regulated human transcriptome: Molecular Cell www.cell.com/molecular-ce...

Sensitive dissection of a genomic regulatory landscape using bulk and targeted single-cell activation Vučićević et al. describe TESLA-seq, which combines pooled CRISPR activation with targeted single-cell RNA-seq to map enhancer-gene connections at high sensitivity. TESLA-seq was applied across a geno...

Sensitive dissection of a genomic regulatory landscape using bulk and targeted single-cell activation: Cell Genomics www.cell.com/cell-genomic...

Unraveling the single cell spatial landscapes of melanoma brain metastases The cellular composition that defines the tumor ecosystem plays a crucial role in determining the responsiveness of tumors to immune checkpoint inhibitors (ICi) and pharmacological blockade of BRAF (B...

www.medrxiv.org/content/10.1...

The Establishment of Cell-Type Specific Gene Regulation in the Sea Urchin Embryo Cell-fate commitment in metazoan development relies on precise gene regulatory programs. This study presents a comprehensive single-cell atlas of gene expression (scRNA-seq), nascent transcription (sc...

www.biorxiv.org/content/10.1...

SPIDR enables multiplexed mapping of RNA-protein interactions and uncovers a mechanism for selective translational suppression upon cell stress SPIDR, a massively multiplexed method that simultaneously maps dozens of RNA-binding proteins to their RNA targets at single-nucleotide resolution, uncovers new RNA-protein interactions and provides c...

www.cell.com/cell/fulltex...

Yes! DEEP-DV geht in die Verlängerung! 🎉
Die DFG hat unserer Forschungsgruppe eine weitere Förderperiode bewilligt – 4 Jahre neue Ideen, Daten und Teamwork!
Danke an alle im Team für den starken Zusammenhalt und an DFG + Gutachter:innen für das Vertrauen in unsere Arbeit. Wir freuen uns riesig! 💪🔬

New paper:
More than 2700 human 3′UTRs are highly conserved. These 3′UTRs are essential components in mRNA templates, as their deletion decreases protein activity without changing protein abundance. Highly conserved 3′UTRs help the folding of proteins with long IDRs.

www.biorxiv.org/content/10.1...

Augmentation of wastewater-based epidemiology with machine learning to support global health surveillance - Nature Water Wastewater-based epidemiology has already proven to be a powerful tool to monitor the spread of a number of diseases. This Perspective discusses the integration with machine learning, highlighting its...

www.nature.com/articles/s44...

Spatial proteomics in translational and clinical research | Molecular Systems Biology EMBO Press is an editorially independent publishing platform for the development of EMBO scientific publications.

www.embopress.org/doi/full/10....

Helmholtz intensiviert Präventionsforschung Die Helmholtz-Gemeinschaft bündelt ihre Aktivitäten in der Präventionsforschung und hat dafür die „Helmholtz Health Prevention Task Force“ ins Leben gerufen. In einem jetzt veröffentlichten Strategiep...

Die @www.helmholtz.de-Gemeinschaft bündelt ihre Aktivitäten in der Präventionsforschung und hat dafür die "Helmholtz Health Prevention Task Force“ ins Leben gerufen. @www.helmholtz-munich.de @mdc-berlin.bsky.social @dzne.science @helmholtzhzi.bsky.social @hzdr.bsky.social @nako.de #Prävention

Join us - NIMSB

nimsb.unl.pt/join-us/

Integrative profiling of condensation-prone RNAs during early development Complex RNA–protein networks play a pivotal role in the formation of many types of biomolecular condensates. How intrinsic RNA features contribute to condensate formation however remains unclear. Here...

I am thrilled to share the first manuscript from my group on identifying sequence and structural features promoting the condensation of RNAs that are organising highly interconnected RNA networks, thereby expanding our understanding of higher-order transcriptome assemblage.
shorturl.at/pmLIj #RNASky

Graphic with text and image showing a young scientist in a lab coat examining a sample slide in a laboratory. The text overlay reads 'SPRING 2025' and 'FULLY-FUNDED PHD POSITIONS.'

Graphic with text and image showing a scientist in a lab coat and purple gloves examining a sample in a laboratory. The text overlay reads 'SPRING 2025' and 'INFORMATION AND APPLICATION > mdc-berlin.de/phd <'."

We are now accepting applications for the spring round of our fully-funded #PhD positions at @mdc-berlin.bsky.social‼️

Apply for your #ScienceCareer in:
▶️ Genes, Cells and Cell-based Medicine
▶️ Molecular Processes and Therapies
▶️ Integrative Biomedicine

👉 www.mdc-berlin.de/phd 👈

Specific tRNAs promote mRNA decay by recruiting the CCR4-NOT complex to translating ribosomes The CCR4-NOT complex is a major regulator of eukaryotic messenger RNA (mRNA) stability. Slow decoding during translation promotes association of CCR4-NOT with ribosomes, accelerating mRNA degradation....

Last #RNAbiology work for the day. This one by the Mendell lab: www.science.org/doi/10.1126/...

m6A sites in the coding region trigger translation-dependent mRNA decay Zhou et al. discovered a specific role of adenosine modifications in the coding region of mRNAs. These chemical alterations slow down the movement of the ribosome during translation and trigger degrad...

Interesting findings by the Zarnack and König labs:
www.cell.com/molecular-ce...
#RNAbiology

Please check related recent work published by:

Tresch lab
pubmed.ncbi.nlm.nih.gov/38753883/

@stirlingchurchman.bsky.social lab
pubmed.ncbi.nlm.nih.gov/38964322/

Pelizzola lab
pubmed.ncbi.nlm.nih.gov/39231948/

Subcellular mRNA kinetic modeling reveals nuclear retention as rate-limiting | Molecular Systems Biology imageimageTranscriptome-wide measurement of subcellular mRNA dynamics in mouse ES cells reveals that nuclear retention is the rate-limiting step in the life-cycle of most mRNAs and provides a resource for understanding spatiotemporal gene ...

Our fantastic collaboration with the lab of Nils Blüthgen @molsysbio.bsky.social has been published:
www.embopress.org/doi/full/10....

#RNASky #RNAbiology @mdc-berlin.bsky.social

www.aaas.org/taxonomy/ter...

International Helmholtz Drug Discovery Conference Already Confirmed Speakers:Kirk Brown                        Alnylam Pharmaceuticals, USA

#RNASky #RNAbiology
Helmholtz Drug Discovery Conference (HDDC2025) www.mdc-berlin.de/HDDC2025
@MDC_Berlin
from April 28-30, 2025