Silvia Fre lab

Good luck dear Robin! 💪

Congratulations to Byung Ho for spearheading this work and our HFSP team!
Curious about the formation of networks of thin lumens and some physics behind it? Take a look at the paper.

Byung Ho is looking for PI positions and he has amazing ideas and leadership.

www.nature.com/articles/s41...

New preprint out now, where we track clonal cancer evolution with barcodes and predict treatment outcome.

It's been several times that I am pretty sure to witness during reviewer crosscommenting assesment mostly generated by AI (composed of hundred of unnecessary and finicky points that would lead to years of revision). For the human reviewer out there, speak up to editor if you notice this !

Check out our beautiful story on tumour clonal dynamics with barcodes, performed in the @frelab.bsky.social by my super talented post-doc @candice-merle.bsky.social and @ivanditerlizzi.bsky.social from @rulands.bsky.social lab!
#barcodes #plasticity

Thank you @patrickpla.bsky.social ! I wish I could have been there this year #FSSCR2025

Congratulations to Bruno Simoes and Rob Clarke! #ENBDC #breastcancer

Thank you so much @doctoremmerson.bsky.social for liking our paper! Looking forward to discussing the implications with you!

Our paper is on the cover of @cp-devcell.bsky.social . Image: embryonic murine salivary-gland explants stained for fate determinants; p63 (cyan) and HES1 (yellow). Thanks to everyone involved.
doi.org/10.1016/j.de...

Thanks a lot @halloulab.bsky.social , looking forward to working together soon!

thank you @campaslab.bsky.social ! The next story together? 😉

Fine-tuning mechanical constraints reveals uncoupled patterning and gene expression programs in murine gastruloids Highlighted Article: A bioinert confinement system enables dissection of how stiffness and timing shape gastruloid development, revealing uncoupling between polarization and transcriptional programs.

Mechanical constraints disrupt gastruloid polarisation without changing gene expression - uncouples morphogenesis & patterning

Gregor & co use tunable hydrogels to show cell motility, not gene expression, drives axis formation in gastruloids

journals.biologists.com/dev/article/...

Contractile fibroblasts form a transient niche for the branching mammary epithelium Nature Communications - Fibroblasts represent a heterogenous cell population but how their differences reflect their plasticity and origin is not fully understood. Here, the authors map the origin...

So proud of the exciting story from my PhD student Jakub Sumbal on contractile fibroblasts shaping branching morphogenesis!
Fantastic collaboration with the lab of Zuzana Koledova in Prague!
@sumbalovakoledova.bsky.social

It just came out online, check it out here:
rdcu.be/eIIKD

Geometry first: how positional cues dictate fate in bilayered epithelia - the Node Behind the paper story focussed on research on early fate decisions in bilayered epithelia.

Geometry first: how positional cues dictate fate in bilayered epithelia thenode.biologists.com/geometry-fir...

Pour mieux comprendre la transformation cancéreuse des cellules mammaires Une exploration des mécanismes moléculaires qui permettent aux cellules mammaires de modifier leur identité donne des éléments fondamentaux pour comprendre certains phénomènes de la transformation can...

Super happy to share the work by my post-doc Candice Merle on breast cancer obtained @institutcurie.bsky.social thanks to funding from ARC:
www.fondation-arc.org/actualites/2...

🧵Just out !
We reveal how 4 branched epithelia—mammary, lacrimal, salivary & prostate—use a conserved YAP–Notch–p63 circuit to self-organize during development & regeneration.
Here’s the story👇
authors.elsevier.com/c/1lM285Sx5g...
Work done in @frelab.bsky.social at ‪
‪ @institutcurie.bsky.social

Bravo Jean Léon and good luck now, I'll be right next door if you have questions! 😉

1000 congrats to Walid @wtklab.bsky.social !!! Plenty of success!

Beautiful and insightful review! Congrats to @sarawickstrom.bsky.social and @clemvilleneuve.bsky.social

#StandUpForScience #StandUpForScience2025

Dev Bio @institutcurie.bsky.social #standupforscience

A research lab from Northwestern, chosen because it's generic and sort of zoomed out. Three scientists are visible in lab coats, and there are benches and shelving, with glass along one wall showing another high-rise building nearby. Overhead fluorescents provide light.

This is a room where we turn very modest salaries and budgets (and lots of coffee) into new knowledge, life-saving innovations, and technology that feeds business growth.

It's literally the loom that spins hay into gold but these numpties are suddenly worried about the cost of hay.

JOB ALERT
We are seeking a Computational Research Assistant or Research Associate to help drive an ambitious multiomics ageing project part of the NMGN Mouse Ageing Cluster.

www.jobs.cam.ac.uk/job/49939/

@scicambridge.bsky.social @phar.cam.ac.uk @cambridgebiosci.bsky.social

The man in charge of social media platforms used by billions should show some moral courage, writes @jemima.bsky.social www.ft.com/content/682c...