Curtis McCloskey

Now online in Cancer Discovery @aacrjournals.bsky.social: Trastuzumab Deruxtecan (T-DXd) Resistance via Loss of HER2 Expression and Binding - by Wanyi Chen, @joshdragomd.bsky.social, @saratchandarlapaty.bsky.social, and colleagues doi.org/10.1158/2159... @mskcancercenter.bsky.social

10.11.2025 18:15 — 👍 5    🔁 5    💬 0    📌 0

Anti-progestin therapy targets hallmarks of breast cancer risk - Nature Results of an early-phase breast cancer prevention trial demonstrate the potential for breast cancer prevention in premenopausal women with anti-progestin therapy by inducing epithelial–stromal remode...

new out in Nature, the Breast Cancer-Anti-Progestin Prevention Study 1 (BC-APPS1; NCT02408770)
www.nature.com/articles/s41...

06.11.2025 07:41 — 👍 7    🔁 1    💬 0    📌 0

Anti-progestin therapy targets hallmarks of breast cancer risk Nature - Results of an early-phase breast cancer prevention trial demonstrate the potential for breast cancer prevention in premenopausal women with anti-progestin therapy by inducing...

Really happy to share a link to our work showing that anti-progestin therapy could help prevent breast cancer before menopause.
Published today in Nature, the study suggests this could be a new way to stop breast cancer before it starts: urldefense.com/v3/__https:/...
Brilliant team science

05.11.2025 21:07 — 👍 24    🔁 12    💬 0    📌 0

Thrilled to see this study out today!! It was a true pleasure working on this story over the past few years led by brilliant collaborators in Manchester and Cambridge. Team science spanning clinical and basic science bringing us closer to breast cancer prevention for premenopausal women!

05.11.2025 19:35 — 👍 2    🔁 0    💬 0    📌 0

A a figure showing comparison of connectomeDB2025 to other ligand-receptor pair databases.

connectomeDB2025: Quality matters!
✅3,579 ligand-receptor pairs supported by 2,803 papers
✅14 vertebrates
❌ >2,900 unsupported pairs from other DBs excluded

connectomedb.org

academic.oup.com/nar/advance-...

@JARamilowski @sakura_maezono @rui_hou_ @weitao_lin @yen_yeow + team

31.10.2025 23:21 — 👍 6    🔁 1    💬 1    📌 0

Physical Activity Linked to Lower Colon Cancer Recurrence | Cancer Today Participating in an exercise program after treatment was associated with a reduced risk of recurrence in people diagnosed with colon cancer.

Recent findings link participating in an exercise program with a lower risk of colon cancer returning, adding to the known benefits of physical activity, even if you are just starting now.

03.07.2025 12:23 — 👍 4    🔁 1    💬 0    📌 0

Post Doctoral Associate Click the link provided to see the complete job description.

I'm excited to announce that my lab is looking to hire a motivated Postdoctoral Associate at the University of Pittsburgh and UPMC Hillman Cancer Center.

Interested in personalized prevention, therapeutics, and women's health research?
📢Learn more:

cfopitt.taleo.net/careersectio...

30.06.2025 13:06 — 👍 0    🔁 1    💬 0    📌 0

Glucose-6-phosphate-dehydrogenase on old peroxisomes maintains self-renewal of epithelial stem cells after asymmetric cell division - Nature Communications Peroxisomes are essential but their role in cell fate regulation remains understudied. Here, the authors reveal that young and old peroxisomes are not equally distributed in asymmetrically dividing st...

Happy to present Hien’s paper on age-selective apportioning of peroxisomes as a fate determinant in adult stem cells www.nature.com/articles/s41... @metastem.bsky.social @helsinki.fi @ki.se @helsinki-biotech.bsky.social out now in @natcomms.nature.com
A thread 🧵 1/9

28.04.2025 10:49 — 👍 48    🔁 16    💬 2    📌 4

Our preprint by @raquelbuj.bsky.social was highlighted! What a cool idea to give early career scientists the opportunity to practice peer review skills! See the updated preprint: www.biorxiv.org/content/10.1....

23.04.2025 22:22 — 👍 16    🔁 6    💬 0    📌 0

A metabolic shift to the serine pathway induced by lipids fosters epigenetic reprogramming in nontransformed breast cells ERneg BCs originates from metabolic mechanisms involving the SOG and methionine pathways.

I am excited to share our latest publication. A big thank you to all the co-authors for their invaluable contributions, and to my mentors for their guidance and support. I also appreciate the support from the #AACR
www.science.org/doi/10.1126/...

21.03.2025 19:05 — 👍 8    🔁 1    💬 0    📌 0