Carolina Tropini (TropiniLab@UBC)

Expanding the Bacteroides synthetic biology toolkit to develop an in vivo intestinal malabsorption biosensor. The human gut is a highly dynamic physical environment where perturbations - including factors such as acidification, oxygenation, and particle concentration (osmolality) - can influence microbiota co...

Sharing exciting work led by PhD students McCallum and Burckhardt! We created a new series of syn bio tools in Bacteroides to create non-invasive, real time and sensitive in vivo gut biosensors. www.biorxiv.org/content/10.1...

Osmotic conditions shape fitness gains and resistance mechanisms during E. coli and T4 phage co-evolution Bacteriophages, or phages, are viruses that infect bacteria and offer a promising approach to combating antimicrobial resistance in the gut by selectively targeting harmful bacteria while preserving t...

Excited to share our latest preprint led by Dr. Hunter! We show that osmotic shifts, common in the gut, alter T4 phage-E. coli evolution. High osmolality promotes fitness but selects for mucoid, weakly phage-resistant E. coli, with implications for phage therapy! biorxiv.org/content/10.1...

Excited to share our latest publication by Adel Yavarinasab et al!

Very excited to share a new paper in collaboration with the Ciernia lab! We show that early-life inflammation alters sex hormones and mating behavior in mice, alongside shifts in hormone-modifying microbiota members! Great work by Olivia Sullivan, Claire Sie and many others! doi.org/10.1016/j.bb...