As many said, I also think @wikipedia.org is one of the rare good places remained on the internet.
Wikipedia is 25! If you use it all the time and want to protect a future where knowledge is human-made, join me and donate now: donate.wikipedia25.org #Wikipedia25
A Sharon Begley byline, almost 5 years after her death.
Upon hearing the news James Watson had died, a STAT reporter said in our Slack, "I wish I could read what Sharon would have written."
Incredible news: Sharon in fact did pre-write a Watson obit. And it is masterful and excoriating.
🧪🧬🧫
That merely being “under review” by a Nature family journal is offered as a quality proxy for a paper is a tragic illustration of the extent to which academia is addicted to brands and outsources evaluation
@biorxivpreprint.bsky.social Regulatory T-cells in multiple sclerosis produce IL-10 in the central nervous system but are activated by Epstein-Barr Virus
www.biorxiv.org/content/10.1...
Integrated epigenetic and genetic programming of primary human T cells - @gladstoneinst.bsky.social @ucsanfrancisco.bsky.social @j-eyquem.bsky.social @marsonlab.bsky.social go.nature.com/3WOJJAJ
Very good 😂. This describes a lot of what is going on accurately.
Credit: @integralanswers.bsky.social
Germinal center–mediated broadening of B cell responses to SARS-CoV-2 booster immunization
Original antigenic sin? No, memory B cells are predominantly recruited to the germinal center, where they undergo further selection and affinity maturation.
www.science.org/doi/...
1/4
Statistics on 100 million people
- I repeat - 100 million people‼️‼️⚠️
Says #shingles vaccine reduces risk of #dementia of 20-30%.
This is mind blowing 🤯
www.nature.com/articles/s41...
Hi. If you're interested in learning more about the state of play in IG and T cell receptor gene curation, check out these articles:
www.sciencedirect.com/science/arti...
@jamieheather.bsky.social @guryaari.bsky.social @williamlees.bsky.social @ayeletperes.bsky.social @elisarosix.bsky.social
6/6 📄 Read the full commentary:
“Challenges for the Immunoglobulin and T cell receptor gene nomenclatures in the modern genomics era”
👉 www.sciencedirect.com/science/arti...
✍️ By Andrew Collins, @cdubsig.bsky.social, Luc Teyton, Henk-Jan van den Ham, Elisa Rosati, @yanasafonova.bsky.social
5/6 What can we do now?
We outline strategies in the paper:
✔️ Clear, provisional reporting formats
✔️ Transparent criteria for future naming
✔️ Global dialogue to shape consensus
Let’s build something better—together.
🧠🌍
iuis.org/committees/n...
4/6 Look up the work of the @iuis-online.bsky.social IG/TR Nomenclature Sub-Committee.
They’re urging caution and precision:
➡️ Don’t rush to name
➡️ Wait for sufficient genomic context
➡️ Use consistent interim strategies for gene reporting
#IUIS #GenomicsPolicy
3/6 The problem?
Old naming rules assumed gene order and structure were mostly conserved.
Now we know that’s not always true.
Assigning permanent names too soon could mislead downstream research.
#NomenclatureMatters #IGTR
2/6 For 30+ years, the IG/TR gene naming system worked well—standardized, community-supported, and extended across species.
But things have changed…
Genomic sequencing is exposing extreme structural variation across individuals and species.
🧬🔍
1/6 🧬 NEW COMMENTARY 🧬
Let’s talk about the challenges in immunoglobulin (IG) & T cell receptor (TR) gene nomenclature in the era of modern genomics.
A 🧵 on why it’s time to rethink how we name these genes—and what it means for immunogenetics.
#IGTR #Genomics #Immunology
This fantastic work by @emilyaunins.bsky.social, Anthony Phan, @drewweissmanlab.bsky.social, @kingofpathogens.bsky.social, & colleagues is featured on this month's cover of #Science #Immunology!
And the second day of #ATCR25 also came to an end. Felt the meeting was a real fresh air of ideas. Super glad I joined. The best part is always to meet with old friends, and the #goodscience of course 😉
I love the location in Antwerp too 😍
First day of #ATCR25 in Antwerp: done ☑️ 🤩
Picture of Antwerp city station
#immunology #TCRrepertoire #Tcells #research
Remember when you first learned about genetics at school? All those fascinating examples of human traits that are each apparently determined by just a single gene? Time to check in on some of your favourites to see how they’re doing. 🧬🧵🧪 1/n
'Unparalleled' snake antivenom made from man bitten 200 times
The blood of a US man who deliberately injected himself with snake venom for nearly two decades has led to an "unparalleled" antivenom, say scientists.
www.bbc.com/news/art...
1/8
New @science.org
An innovative way to deliver drugs to the gut at low doses to suppress inflammation
www.science.org/doi/10.1126/...
Cool pre-print in my feeds this morning, using a neat trick weighting TCRs by similarity prior to DGE better resolve differential usage. Seems to be a clever trick to make TCRseq behave a little more like regular RNAseq data and better use regular stats/tools:
www.biorxiv.org/content/10.1...
Direct presentation of endogenous antigen on MHC II is crucial to mRNA-LNP vaccine-induced immune responses
doi.org/10.1101/2025...
42-Parameter (40-Color) Spectral Flow Cytometry Panel for Comprehensive Immunophenotyping of Human Peripheral Blood Leukocytes
doi.org/10.1002/cyto...
T-bet+ CXCR3+ B cells drive hyperreactive B-T cell interactions in multiple sclerosis
www.sciencedirect.com/science/arti...
check out our new manuscript (led by Gian Marco Visani):
structure-based machine learning model for TCR-pMHC complexes, predicting T-cell affinity to peptide-MHC complexes, quantifying T-cell receptor specificity, and designing de-novo immunogenic peptides:
arxiv.org/abs/2503.00648
Excited to see our new single cell immunology tool out now in @naturecomms.bsky.social. We made "Single cell suppression profiling of human regulatory T cells" to generate a human model to screen for cell-type specific effects on all immune cells simultaneously.
www.nature.com/articles/s41...
