Carlyle Group

Immunoassay for pyruvate kinase M1/2 as an Alzheimer’s biomarker in CSF Alzheimer’s disease (AD) is characterized by amyloid-beta plaques and tau tangles in the brain, but these markers alone do not predict disease progression. The intersection of these pathologies with o...

#TuesdayReads:
Becky Carlyle et al develop and validate an ELISA to measure PKM in cerebrospinal fluid—linking elevated levels to accelerated cognitive decline in Alzheimer’s and highlighting PKM as a potential early biomarker.
🔗 www.degruyterbrill.com/document/doi...

Banner for a guest blog by Dr Becky Carlyle titled “Everythings Distribution.” It shows cartoon panels of a scientist with charts, alongside a portrait of Dr Carlyle. The post is about clear and transparent data presentation in research.

Can a t test change your life? It did for Dr Becky Carlyle. Read why better figures make better science. @bcarlylegroup.bsky.social

www.dementiaresearcher.nihr.ac.uk/blog-present...

Immunoassay for pyruvate kinase M1/2 as an Alzheimer’s biomarker in CSF Alzheimer’s disease (AD) is characterized by amyloid-beta plaques and tau tangles in the brain, but these markers alone do not predict disease progression. The intersection of these pathologies with o...

Very exciting news today— Carlyle lab member Matt paper is finally out 🥳 They’ve developed an immunoassay for PKM1/2 in cerebrospinal fluid, with more work on this to follow in future!

You can check the full paper here:
www.degruyterbrill.com/document/doi...

A compilation of reported alterations in the cerebrospinal fluid proteome in Alzheimer's disease de Geus et al. report that a compilation of CSF proteomics studies in Alzheimer’s disease identified 61 consistently altered proteins across mass spectrome

We have a new paper alert🎉

This work compiles all reported protein changes in the cerebrospinal fluid of Alzheimer’s patients across studies using mass spectrometry, Olink, and SomaScan platforms.

Check it out here:
academic.oup.com/braincomms/a...

#Alzheimers

To all ARUK Thames Valley Network!

Join us for the Research Day 👩‍🔬
Wednesday 18th June | University of Oxford

Our group will be sharing some posters—come by if you’d like to connect, chat or learn more about our research!

#ARUK #Dementia
@arukthamesv.bsky.social
‬

#MeetTheResearcher
Introducing Aya Abdallah this week, from the @bcarlylegroup.bsky.social, @oxforddpag.bsky.social

Aya studies protein quantification in Alzheimer’s Disease using proteomics, SIMOA, ELISA & OLINK.

#Neuroscience #Alzheimers #OxfordNeuro #WomenInSTEM

Dr Becky Carlyle - Blog – It Could Happen Here: Defending Research from Politics Dr Becky Carlyle explores how researchers can defend science from political threats and reconnect with communities. A timely, passionate guest blog.

“If the public doesn’t see value in our work, they won’t defend it when the cuts come.” @bcarlylegroup.bsky.social

www.dementiaresearcher.nihr.ac.uk/blog-it-coul...

Postdoctoral Researcher in Neuronal Dysfunction in Alzheimer’s Disease, Oxford-GSK Institute of Molecular and Computational Medicine at University of Oxford Explore an exciting academic career as a Postdoctoral Researcher in Neuronal Dysfunction in Alzheimer’s Disease, Oxford-GSK Institute of Molecular and Computational Medicine. Don't miss out on other a...

Do you have lots of iPSC skills and an interest in Alzheimer's Disease? Our GSK-IMCM Alzheimer's Disease team is looking for a new Post Doc, to work with the excellent Hugo Fernandes. More info here: www.jobs.ac.uk/job/DMV315/p...

A promotional graphic for Dr Becky Carlyle’s guest blog on mentoring, titled "Choose Your Mentors," featuring Dr Carlyle's portrait, stylised text, and images symbolising different mentors, some circled or crossed out, highlighting the process of mentor selection.

Sometimes mentoring is just group ranting about admin struggles. Ever had one of those sessions? Dr Becky Carlyle gets it! #AcademicLife #MentorMoments @bcarlylegroup.bsky.social

www.dementiaresearcher.nihr.ac.uk/blog-choose-...

015 - 'Cognitive Resilience and Alzheimers' with Dr Becky Carlyle The Dementia Dialogues · Episode

Wondering how to protect your brain health? Check out this episode with our group leader, Becky, as she shares her research on brain resilience, her journey as a leader, why hearing aids matter, and how staying social boosts brain health!

#Dementia

open.spotify.com/episode/7M1H...

Not having a supervisor around can be stressful, especially for a first-year PhD student!

Check out this article where our leader, Dr. Carlyle, has introduced great ideas on how to tackle this issue!

#dementia
#PhD

Dr Becky Carlyle - Blog – How on earth do I hire my team?! Struggling with hiring your first lab team? Dr Becky Carlyle shares expert tips to help you recruit the right people and build a successful research group!

💡 Great hires make great labs. But how do you find the right people? Dr Becky Carlyle shares practical advice for hiring in research. #ResearchCareers

www.dementiaresearcher.nihr.ac.uk/blog-how-on-...

The Carlyle Group has just returned from the ARUK Research Conference 2025!🎉

We had the opportunity to present two posters, attended many scientific talks, and connected with great minds.

Great time in Birmingham— looking forward to seeing you next in Manchester!

#ARUK @alzheimersresearchuk.org

Carlyle Group Proteome complexity in neurodegenerative and neuropsychiatric disease

Visit the group's website for more information: www.dpag.ox.ac.uk/research/car...

@ox.ac.uk @oxforddpag.bsky.social @medsci.ox.ac.uk @kavlifoundation.bsky.social #KavliOxford

#MeetTheLab

Introducing the Carlyle Group this week: Their research combines proteomic techniques on post-mortem brain tissue with cellular models to explore how protein-level changes affect brain cell health and communication.
@bcarlylegroup.bsky.social

Unbiased CSF Proteomics in Patients With Idiopathic Normal Pressure Hydrocephalus to Identify Molecular Signatures and Candidate Biomarkers | Neurology Background and ObjectivesIdiopathic normal pressure hydrocephalus (iNPH) is a reversible neurologic disorder that remains poorly understood. Accurate differential diagnosis of iNPH and Alzheimer disea...

Exciting news— Dr. Carlyle and Matthijs de Geus work on CSF biomarkers for Idiopathic Normal Pressure Hydrocephalus (iNPH) has just been published! Congratulations to both for your amazing work! 👏

Check the paper out here:
www.neurology.org/doi/10.1212/....
@kavlioxford.bsky.social

Yasmin Bonsu - Blog – Final Semester: Uncertainty, Applications & Balance 🎓 Yasmin Bonsu shares insights on navigating final-year challenges, PhD applications, rejection, and work-life balance. A must-read for students & grads!

Check out our awesome former year in industry student, Yasmin’s latest blog! She shares all about her final year experience and some super helpful tips for writing a great PhD application!

#Dementia

www.dementiaresearcher.nihr.ac.uk/blog-final-s...

The image features a promotional design for a guest blog titled "To teach or not to teach" by Dr Becky Carlyle, who is a Senior Research Fellow at the University of Oxford. The background is styled as a blackboard with white chalk text forming the title and a large question mark. Dr Carlyle's photo is positioned on the right, showing her smiling and wearing glasses. The text and design elements are intended to evoke a classroom or educational theme.

Find out how Dr Becky Carlyle merges teaching duties with her research projects, illustrating the practicalities and profound rewards of her academic journey.

https://buff.ly/4gfr9sX

Check out our amazing placement student, Yasmin Bonsu, sharing her top tips and valuable resources for navigating opportunities.

Check out her post here and feel free to share your own tips in the comments!

#Dementia #StudentLife

How the cognitively resilient can swerve dementia Scientists are looking at how DNA differences could protect people from dementia – and how this can help others

Check out this—Dr. Carlyle work was spotlighted in the Telegraph!

Follow the link to read more.

#Dementia

Meet our amazing leader👩‍🔬
She will be sharing her journey of starting a new lab and much more. Stay tuned to know more about her experience!
#Dementia

Happy New Year, everyone! 🎉

Just a quick introduction—I’m Hend Almunaidi, the person managing this account. I'm a first year DPhil student and will be sharing updates on all the exciting things happening in our lab. Excited to connect with you all!

YouTube video by Kavli Nano Kavlonians for Peace on Earth!

At #KavliOxford, we believe science can bridge divides and unite. This year, our diverse community shares a heartfelt message of peace on earth in their own languages. 🌍✨

Wishing everyone peaceful holidays and a joyful winter season! ❄️

#PeaceOnEarth #ScienceUnites #DiversityInScience

Welcome to our official group account 🎉 We are based in @oxforddpag.bsky.social & @kavlioxford.bsky.social at the University of Oxford. We are interested in unraveling resilience to Alzheimer’s disease and mental health problems. Follow us for updates on our latest research and our journey!