Joshua McGrath

AIRR Community Seminar Series - The Antibody Society Join the AIRR Community for a 90 minute “lab-style” virtual seminar. Each month an established and an early career scientist will discuss their AIRR-seq related research. Seminar time will be 16:00 – ...

The next AIRR-C seminar is scheduled for June 26 at 1600 CET, 1000 ET, 700 PT with Rohit Sing @rohitsingh8080.bsky.social (antibody PLMs) and @joshuamcgrath.bsky.social (immunoglobulin codon mutability). Register here: antibodysociety.org/the-airr-com...

Protective antibodies target cryptic epitope unmasked by cleavage of malaria sporozoite protein The most advanced monoclonal antibodies (mAbs) and vaccines against malaria target the central repeat region or closely related sequences within the Plasmodium falciparum circumsporozoite protein (PfC...

Exciting study from the Tan group about a cryptic, immunosubdominant but protective Ab epitope on Plasmodium sporozoites. Generated only through cleavage and pyroglutamation of PfCSP surface protein. Big news for epitope-targeting malaria vaccines and mAb therapeutics
www.science.org/doi/10.1126/...

Using protein large language models to optimize antibodies to SARS-CoV-2 with >20-fold increase in binding affinity

www.pnas.org/doi/10.1073/... @pnas.org

Mutability and hypermutation antagonize immunoglobulin codon optimality McGrath et al. investigate the evolutionary relationship between V(D)J mutability, somatic hypermutation, and codon optimality within immunoglobulin repertoires in order to gain a better understanding of how diversification mechanisms might impact antibody expression efficiency.

Pleased to share our work looking at the evolutionary relationship between mutability, somatic hypermutation and codon optimality in human immunoglobulin genes and V(D)J repertoires. Such a fun project – check it out, online now at Molecular Cell! @cellpress.bsky.social
www.cell.com/molecular-ce...