David Teis

...explores an 'experiment of nature' to highlight the broad principles underlying the organisation and evolution of membrane homeostasis....
cool!

....explores an 'experiment of nature' to highlight the broad principles underlying the organisation and evolution of membrane homeostasis....
cool!

👏👏

We have wondered what a complex archaeal cell might look like ever since 2014. It’s been a long road (and the journey is far from over), but it’s a good time to pause for breath and look. These Asgard archaeal cells are a surprise! And that is the joy of being a cell biologist.

An Asgard archaeon with internal membrane compartments

Brilliant study led by @fmacleod.bsky.social and Andriko von Kügelgen. Tight collaboration with @buzzbaum.bsky.social and lab. Congrats to all authors!

www.biorxiv.org/content/10.1...

📢 Open Call! The Max Perutz Labs invite applications for a Full Professorship in Integrative Structure Biology with a focus on in situ structural biology using cryo-electron tomography (cryo-ET) and related methods. More details ➡️ tinyurl.com/brswbymu

Mechanism of autophagy initiation by transmembrane selective autophagy receptors | The EMBO Journal EMBO Press is an editorially independent publishing platform for the development of EMBO scientific publications.

Our latest review is now online! 👇

@martenslab.bsky.social

Mechanism of autophagy initiation by transmembrane selective autophagy receptors | The EMBO Journal www.embopress.org/doi/full/10....

👏👏

VPS13C/PARK23 initiates lipid transfer and membrane remodeling for efficient lysosomal repair Perturbations in lysosome integrity are tightly linked to neurological disorders and ageing, but the underlying pathogenic mechanisms are incompletely understood. Using an unbiased proteomic approach,...

Proud to share a preprint of our paper on how bridge-like lipid transport protein VPS13C senses lysosomal membrane tension in anticipation of membrane lesions to initiate net ER-to-lysosome lipid transfer for efficient lysosomal repair www.biorxiv.org/content/10.1...

How do cells curb nutrient uptake during quiescence & does it matter?
@teislab.bsky.social & Co. show TXNIP-dependent endocytosis of amino acid transporter LAT1/SLC7A5 is essential to prevent cell death and human disease
#RefereedPreprint c/o @reviewcommons.org
www.embopress.org/doi/full/10....

Quiescent cells stay alive by eating less. They downregulate amino acid transporters to match reduced demand. When this brake fails -> cell death & disease.
More info in our new paper 👇

Just out in @science.org: Together with the lab of @wilhelmpalm.bsky.social, we used sequential in-vitro/in-vivo CRISPR screens to decipher metabolic adaptations in tumors. We find that acidosis is a dominant factor that shapes energy metabolism and stress resilience. www.science.org/doi/10.1126/...

A Leishmania virulence factor harnesses an allosteric kinase switch to regulate its ubiquitin ligase activity Stringent control of ubiquitylation is a central requirement of signaling specificity in eukaryotes. Here, we discover a domain module integrating pro…

Allosteric activation of a ubiquitin ligase by an internal kinase domain! Congratulations to our team member Thornton Fokkens for this fascinating discovery in a neglected disease area with strong therapeutic need. Many thanks to all our great collaborators!
www.sciencedirect.com/science/arti...

🥳 MEGA NEWS: Michi Ebner has been awarded an ERC Starting Grant for his research on Lysosomal Lipid Logistics!
PhD students and Postdocs: Join him at the Institute of Molecular Biochemistry (biochem.i-med.ac.at/ebner) at the Biocenter of the Medical University of Innsbruck!
Just awesome science!

come for a visit

rob! way to go🥳 congrats!

🥳 congrats hesso and team - targeting the folded protein response kills multiple myeloma

Targeting proteostasis in multiple myeloma through inhibition of LTK Leukemia - Targeting proteostasis in multiple myeloma through inhibition of LTK

Our new paper is out in Leukemia on Targeting proteostasis in multiple myeloma through inhibition of LTK. Thanks to Ludvig and Thea for this great collaborative work
rdcu.be/evyfX

excellent PhD opportunity if you are interested in studying the cell biology of CART cell and AML interaction!! apply now ! also we work in a nice location in the heart of the alps

Our lab is hiring 1 PhD and 1 Postdoc to study the mechanism of lipid transport using computational methods (Molecular Dynamics, AI). Fully funded by @snsf-ch.bsky.social for 4 years, with amazing collaborators and excellent life and working conditions. Apply by email. Please share and repost!

Bryce Brownfield's review on the structural biology of Golgi trafficking has been published!
authors.elsevier.com/a/1kqrY3PA3s...

Bryce is now a postdoc in the @buzbarstow.bsky.social lab, we miss him dearly!

thank you - it’s an important paper!!

Any1 is a phospholipid scramblase involved in #endosome biogenesis, say Jieqiong Gao, Christian Ungermann and colleagues (Osnabrück University): rupress.org/jcb/article/...

#Membrane #lipid #Organelles #Biochemistry

An in vitro platform for the enzymatic characterization of the rhomboid protease RHBDL4 Rhomboid proteases are ubiquitous intramembrane serine proteases that can cleave transmembrane substrates within lipid bilayers. They exhibit many and…

Our work is finally published! We developed a robust in vitro platform to study a disease relevant membrane protease, notoriously difficult to isolate.This protease has linked to cancer & neurodegen,and our platform opens new doors for structural & drug discovery.
sciencedirect.com/science/arti...

Excited to see work led by @autophazeke.bsky.social, @minghaochen.bsky.social, Thanh Nguyen, and Ainara Claveras out in @science.org today, the culmination of a 15-year project to understand structurally how the synthesis of the critical lipid of autophagy, PI3P, is regulated. tinyurl.com/ywvjh8u4

the disciples of ERES

I am looking for a #PhD working on this exciting project! In case you are interested in how #immunometabolism and #macrophages affect #adipose tissue function, check the link below and apply! www.immunometabolism.at/job-openings/

👍

A unique postdoc position in academic drug discovery is open in the Hurley lab. We have a biochemistry-driven Parkinson’s disease drug discovery project funded and supported by SPARK-NS, which has an innovative model that turbocharges drug discovery in academic labs.
(thread continues)

PhDs in biochemistry, structural biology, pharmacology, or similar, located in the US and with strong publication track records and a high motivation to solve Parkinson's, please send CV directly to me at jimhurley@berkeley.edu.
Repost appreciated.