Hartmut Vodermaier

SUMOylation: From discovery to translation Sumoylation is an essential post-translational modification that regulates thousands of target proteins in a dynamic manner. Small ubiquitin-like modifiers (SUMOs) can be attached to target proteins …

On the train to Montpellier for the #EMBOsumoylation conference - looking forward to the 2nd recurrence of this #EMBOevents workshop and to the latest research in the SUMO field!
meetings.embo.org/event/25-sum...

I continue to be astounded by the recent resurgence of intriguing studies revolving around #PARPs and the interplay of ADP-ribosylation with other PTMs! Latest example that we published in @embojournal.org:

Was fun to work on this manuscript - never would have thought that an E1 enzyme could be involved in selecting a particular #ubiquitin -like protein isoform over another!

Our RNA & translation editor Cornelius Schneider is excited to be at #EMBLProtein starting tomorrow – make sure to say Hi to him and drag him to your posters 😀
@events.embl.org ‬

Fascinating new insights into evolutionary conservation/diversification/repurposing in the chromosome segregation machinery!

hasn't been an issue anymore in recent years, almost no-one opts out anymore. Maybe because we allow removal of referee figures that authors may want to include in future studies

Opt-out frequency was up to 1/3 when we first started our Transparent Peer Review process @embojournal.org but I don't recall any obvious trends towards certain author groups

Another week, another great conference - happy to be at #EESAgeing on home turf

Partisan battle lines form over Trump's plan to defund NPR & PBS Senate Democrats warn Trump plan to wipe out public broadcasting funding will shut down stations, eliminate essential services. But House GOP scheduled to vote to clawback $1.1 billion next week.

Senate Democrats warn Trump plan to wipe out public broadcasting funding will shut down stations, eliminate essential services. But House GOP scheduled to vote to clawback $1.1 billion next week.

Drosophila Genetic Database The Drosophila Genetic Database, FlyBase, is on the brink of collapse due to the sudden termination of the FlyBase NIH grant, which includes salaries for 5 literature curators based at the University ...

This vital resource @flybase.bsky.social is in acute peril: its funding blocked by the vindictiveness of Trump. Emergency funds needed *now*, pending longer term solutions. Personal donations from Europe can be made here (UK taxpayers can gift-aid); other routes also possible. US appeal to follow.

A scary situation!

‘Anyone can do this’: Sleuths publish a toolkit for post-publication review For years, sleuths – whose names our readers are likely familiar with – have been diligently flagging issues with the scientific literature. More than a dozen of these specialists have teamed up to cr...

‘Anyone can do this’: Sleuths publish a toolkit for post-publication review

@averyorrall.bsky.social reports on an initiative from @reeserichardson.bsky.social and colleagues

If you are interested in pursuing a postdoc combining proteomics a genomics with functional molecular biology to study ubiquitin (-like) signaling in genome biology we are looking for candidates for the next MSCA Fellowships call!!!!

Today, these amazing NKI researchers are pushing their limits by climbing the Alpe d’Huez. Go for it lovely people! We are proud to see so many of you dedicate your time and effort to supporting cancer research.
With @oncodeinstitute.bsky.social

#AlpedHuZes #cancerresearch #ad6 #NKI

Grateful for the opportunity to meet with so many enthusiastic early-career scientists and sharing behind-the-scenes insights with them #wUeBI2025

Excited that the symposium #wUeBI2025 @grk2243.bsky.social is now about to start - looking forward to exciting news from the #ubiquitin field, and to meeting this great community again!

Ever wondered how it would be as an Editor?
Here's your chance to try as an absence cover with our wonderful colleagues from @emboreports.org!

Tariffs xkcd.com/3073

Lungfish xkcd.com/3064

Great to get to publish another one on the emerging connections between ADP-ribosylation, immune signaling, ubiquitin and protein aggregation/degradation

T-cell-derived IFN-γ suppresses T follicular helper cell differentiation and antibody responses | The EMBO Journal imageimageSubcutaneous infection by lymphocytic choriomeningitis virus (LCMV) is characterized by skewed CD4+ T-cell polarization, as well as severely impaired differentiation of T follicular helper (...

💡Exciting news! Our latest study, in collaboration with Prof. Mirela Kuka’s lab, is out now—uncovering how T cell–derived IFN-γ can suppress T follicular helper (TFH) cells and limit antibody responses. 🚀🧵(1/10) www.embopress.org/doi/full/10....

This cover highlights the article PLK1 inhibition delays mitotic entry revealing changes to the phosphoproteome of mammalian cells early in division by M. Gobran, P. Lenart and colleagues. HeLa Kyoto cells treated with the PLK1 inhibitor BI2536 spend prolonged periods of time in a prophase-like state with condensed chromosomes. Cells stained with 5-SiR-Hoechst imaged on a spinning disk confocal microscope. Scientific image by Monica Gobran

Highlighted in Issue 7:
Lysosome-CDK4/6 co-targeting in cancer therapy
Algal spliceosome structure
Also:
Opposite synaptic plasticity effects of Ras isoforms
Novel biosensor for spatiotemporal dynamics of STING activation
Cover: @plenart.bsky.social and coworkers
www.embopress.org/toc/14602075...

Artificial intelligence learns to reason Julia has two sisters and one brother. How many sisters does her brother Martin have?Solving this tiny puzzle requires a bit of thinking. You might mentally picture the family of three girls and one b...

From large language models (LLMs) to large reasoning models (LRMs) based on chain-of-thought. Are LRMs "“genuinely reasoning” or “merely mimicking” the kinds of human reasoning that is in the pretraining or post-training data"?
Interesting read ➡️ www.science.org/doi/10.1126/...

Not to over-rate journal rankings - but this is nevertheless surely good news!

Lu Gan (甘露) and collaborators use cryo-electron tomography to reveal the nanoscale architecture of human #chromatin in situ: G1 and metaphase chromatin is devoid of mega-complexes beyond dinucleosome regularities
www.embopress.org/doi/full/10....

In issue 6:
Commentary: organoids for decoding host-microbe interactions
Importance of mitochondrial DNA elimination during spermatogenesis
How kinesin KIF12 promotes steatohepatitis
Cancer cell adaptation strategies to aneuploidy
Cover: Daniel Ott, Anne Spang et al
www.embopress.org/toc/14602075...

Medicine & Society: The human condition
A virtual seminar series coorganized by @embopress.org - feel free to subscribe & attend!
cancerprev.com/medicine-soc...

This cover highlights the article Multimodal mechanisms of human centriole engagement and disengagement by Kei K. Ito, Shoji Hata, Daiju Kitagawa and colleagues. The cover image depicts the centriole cycle as marked by acetylated tubulin. Daughter centrioles form on mother centrioles (yellow) and undergo stepwise engagement (blue, green, red) before disengaging (purple) to become new mother centrioles. Scientific image by the authors

In issue 5:
Review: Arginine in the center of cellular nitrogen metabolism
Elongator polymerizes polyglutamylated tubulin
Shu complex HR factor to the replication fork!
Ephrin as EGFR ligand promotes gastric cancer metastasis
Cover by Ito, Hata, Kitagawa et al
www.embopress.org/toc/14602075...

The ageing genome: from mechanisms to disease

Register and submit your abstract now: The ageing genome: from mechanisms to disease www.embl.org/about/info/c...

don't tell our @embojournal.org RNA editor...