Sami Chaaban's Avatar

Sami Chaaban

@sami-c.bsky.social

Postdoc in the Carter Lab at the MRC-LMB. EMBO fellow. Alumnus of the Brouhard Lab.

145 Followers  |  143 Following  |  1 Posts  |  Joined: 11.11.2024  |  1.5457

Latest posts by sami-c.bsky.social on Bluesky

We have an opening for a research support officer. Come and join us! Please share.

22.12.2025 12:09 β€” πŸ‘ 17    πŸ” 22    πŸ’¬ 0    πŸ“Œ 0
Post image

Congrats to Michal Wieczorek (wieczorekgroup.ethz.ch/research.html, IMBB) on being selected as an @embo.org Young Investigator. The 2024 cohort highlights excellence across the life sciences, and this recognition reflects Michal’s outstanding scientific contributions.

02.12.2025 14:28 β€” πŸ‘ 9    πŸ” 3    πŸ’¬ 1    πŸ“Œ 0
HMS - Postdoctoral Fellow in BCMP, Brown Lab We invite applicants for a postdoctoral fellow position in the Brown lab at Harvard Medical School in Boston, Massachusetts. The Brown lab uses structural, biophysical, and biochemical approaches to d...

Our lab is seeking a Postdoctoral Fellow. The position is intentionally broad, as we are looking for outstanding researchers from diverse scientific backgrounds to advance our understanding of cilia and ciliopathies: academicpositions.harvard.edu/postings/15526

18.11.2025 20:05 β€” πŸ‘ 21    πŸ” 19    πŸ’¬ 0    πŸ“Œ 1
Post image

An Asgard archaeon with internal membrane compartments

Brilliant study led by @fmacleod.bsky.social and Andriko von KΓΌgelgen. Tight collaboration with @buzzbaum.bsky.social and lab. Congrats to all authors!

www.biorxiv.org/content/10.1...

07.11.2025 10:44 β€” πŸ‘ 387    πŸ” 170    πŸ’¬ 10    πŸ“Œ 22
Preview
Wilkinson Lab We discover and study reverse transcriptases

The Wilkinson Lab is open for science! @mskcancercenter.bsky.social

🧬We'll be finding funky new RNA biology, mainly by looking at reverse transcriptases (i.e. the Best Enzymes In The World)🧬

annnd: I'm hiring - come join! Especially postdocs and PhD students - please get in touch (NYC is great)

31.10.2025 19:00 β€” πŸ‘ 97    πŸ” 46    πŸ’¬ 5    πŸ“Œ 3

Gorgeous website

31.10.2025 21:51 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
Post image

Please RT. Post-doc opportunity alert! πŸ’₯ closing 10th December.. Come join our team (www.thelowlab.org) at Imperial, London, working on the structure and mechanism of bacterial secretion systems.

For more details and to apply please see

www.imperial.ac.uk/jobs/search-...

29.10.2025 17:11 β€” πŸ‘ 48    πŸ” 40    πŸ’¬ 1    πŸ“Œ 0
Quick Check Needed

We are looking for a computational postdoc to work with us on new optimisation algorithms to make #RELION even better. Join our bubbly team at the @mrclmb.bsky.social in Cambridge, UK. πŸ€— RTs appreciated.

mrc.tal.net/vx/appcentre...

29.10.2025 09:17 β€” πŸ‘ 64    πŸ” 57    πŸ’¬ 2    πŸ“Œ 2

This one is a bit of a departure from the usual and definitely a work in progress!

We found that by using ab initio reconstruction at very high res, in very small steps, we could crack some small structures that had eluded us - e.g. 39kDa iPKAc (EMPIAR-10252), below.

Read on for details... 1/x

13.09.2025 00:04 β€” πŸ‘ 266    πŸ” 82    πŸ’¬ 20    πŸ“Œ 14
Video thumbnail

Excited to share our latest work with @simonbullock11.bsky.social! We looked at how diverse mRNAs get selected for subcellular localization and it turns out that a single protein can recognize different RNA elements using shared features that weren’t apparent before.
www.biorxiv.org/content/10.1...

05.08.2025 10:43 β€” πŸ‘ 143    πŸ” 45    πŸ’¬ 4    πŸ“Œ 9
Post image

Great to see our story on dynein & kinesin co-dependence published www.nature.com/articles/s41..., and absolutely chuffed that it's made the front cover (thanks NSMB!). A brilliant News & Views too by Steven Markus www.nature.com/articles/s41.... Collab between @carter-lab.bsky.social & Straube labπŸ”¬

24.04.2025 10:17 β€” πŸ‘ 26    πŸ” 8    πŸ’¬ 1    πŸ“Œ 1

Happy to have contributed a small part to this exciting story about the ancestors of eukaryotic tubulin in Asgard archaea. Congratulations to all the co-authors!

22.03.2025 08:02 β€” πŸ‘ 11    πŸ” 2    πŸ’¬ 1    πŸ“Œ 0
Preview
Microtubules in Asgard archaea Discovery of heterodimeric, microtubule-forming tubulins in Asgard archaea, the closest known relatives of eukaryotes, reveals snapshots of microtubule evolution.

Microtubules in Asgard archaea 🀩🀩 www.cell.com/cell/fulltex...

21.03.2025 19:43 β€” πŸ‘ 40    πŸ” 10    πŸ’¬ 4    πŸ“Œ 0

Extremely happy to see our work finally out!πŸŽ‰ Great collaboration between @rouxlab.bsky.social @buzzbaum.bsky.social labs and a real pleasure to work and share co-first authorship with incredible scientists and friends @diorgeps.bsky.social @sami-c.bsky.social. Big thanks to the rest of the authors!

11.02.2025 13:02 β€” πŸ‘ 26    πŸ” 8    πŸ’¬ 0    πŸ“Œ 0
Evolution, structure and membrane remodelling function of the ESCRT-III superfamily in eukaryotes and their closest relatives Asgard archaea. The two subfamilies, B-type and A-type, have distinct structural properties to perform sequential steps of the membrane remodelling pathway.

Evolution, structure and membrane remodelling function of the ESCRT-III superfamily in eukaryotes and their closest relatives Asgard archaea. The two subfamilies, B-type and A-type, have distinct structural properties to perform sequential steps of the membrane remodelling pathway.

New research on ancient Asgard archaeal ESCRT-III proteins reveals evolutionary secrets of membrane remodelling.
Diorge Souza, Javier Espadas and Sami Chaaban, investigated the ESCRT-III proteins with Buzz Baum and Aurelien Roux.
Read more: www2.mrc-lmb.cam.ac.uk/asgard-archa...
#LMBResearch (1/2)

11.02.2025 12:46 β€” πŸ‘ 33    πŸ” 12    πŸ’¬ 1    πŸ“Œ 1
Post image

How do great discoveries sometimes come from unexpected findings? It’s right there in the first paragraph of Fleming’s paper: a contaminated plate led to the discovery of penicillin.

Much work was required to turn the discovery into practice, but this simple observation started it all.

04.12.2024 14:10 β€” πŸ‘ 21    πŸ” 12    πŸ’¬ 0    πŸ“Œ 1
Post image

Please share this PhD opportunity in my new lab in Bristol, using protein design/ engineering to understand and build molecular motors to control intracellular transport. Working with @markdodding.bsky.social and Prof Dek Woolfson.
www.findaphd.com/phds/project...
www.swbio.ac.uk/biomolecular...

28.11.2024 16:55 β€” πŸ‘ 58    πŸ” 39    πŸ’¬ 3    πŸ“Œ 3
This scheme shows the cargo adaptor FHF in the middle with arrows pointing to distinct microtubule and actin-based motors (dynein-dynactin, KIFC1, KIF1C and myosins V, IX and X as well as Tropomyosin 1). It also shows a link to Rab5 marked early endosomes. The hypothesis is that FHF coordinates multi motor binding at the early stages of endocytosis. The PhD project would address the hierarchy of motor binding and how these motors coordinate to allow the newly formed vesicle to transition from the actin to MT cytoskeletal network.

This scheme shows the cargo adaptor FHF in the middle with arrows pointing to distinct microtubule and actin-based motors (dynein-dynactin, KIFC1, KIF1C and myosins V, IX and X as well as Tropomyosin 1). It also shows a link to Rab5 marked early endosomes. The hypothesis is that FHF coordinates multi motor binding at the early stages of endocytosis. The PhD project would address the hierarchy of motor binding and how these motors coordinate to allow the newly formed vesicle to transition from the actin to MT cytoskeletal network.

If you’re interested in how molecular motors coordinate to power intracellular trafficking events (e.g. endocytosis), I’ve got a PhD position available to study this at vibrant Bristol uni. In this project, we will capture highly dynamic events by #cryoEM, single molecule imaging & cell biology. πŸ”¬β„οΈπŸ§ͺ

27.11.2024 12:15 β€” πŸ‘ 54    πŸ” 30    πŸ’¬ 1    πŸ“Œ 7
Preview
The intraflagellar transport cycle - Nature Reviews Molecular Cell Biology Intraflagellar transport (IFT) ensures delivery of selected proteins into cilia. The IFT protein complexes IFT-A and IFT-B polymerize at the base of the cilium to form an anterograde train that facili...

Our review of Intraflagellar transport is out now! We cover lots of the recent advances in our understanding of IFT, and where we think there are still some gaps.
www.nature.com/articles/s41...

18.11.2024 11:06 β€” πŸ‘ 86    πŸ” 28    πŸ’¬ 2    πŸ“Œ 2
Bluesky Network Analyzer Find accounts that you don't follow (yet) but are followed by lots of accounts that you do follow.

FOMO? The below is really good to find people your followers are following, but you are not.
#OpenSoftwareAcceleratesScience
bsky-follow-finder.theo.io

17.11.2024 09:01 β€” πŸ‘ 14    πŸ” 6    πŸ’¬ 1    πŸ“Œ 0
Preview
Run

Using interactive web-viz for sharing results lossless is always an option! In this case it's as easy as clicking "View Tomogram" here: cryoetdataportal.czscience.com/runs/14185

16.11.2024 19:03 β€” πŸ‘ 9    πŸ” 3    πŸ’¬ 2    πŸ“Œ 0

@sami-c is following 20 prominent accounts