Lance Johnson

Clonal expansion of cytotoxic CD8⁺ T cells in lecanemab-associated ARIA Amyloid related imaging abnormalities (ARIA) remain the principal safety concern limiting adoption of anti amyloid therapies such as lecanemab, yet their underlying biology is poorly defined. To addre...

🚨Fresh pre-print collab with @johnsonlab.bsky.social, Norton Healthcare, and our @uksbcoa.bsky.social collaborators. We report a coordinated CD8+ Tcell immunometabolic program associated with amyloid-related imaging abnormalities (ARIA) during lecanemab therapy👇

🔗 www.medrxiv.org/content/10.1...

new preprint from @iostephens.bsky.social describes the potential benefits of increasing lipid turnover in microglia by eliminating PLIN2 from their surface

Are you an ATP!?!

We are hosting our 2nd annual CNS MET Symposium 12/3/25 and are searching for early-career researchers to highlight as All-star Trainee Presentations (ATPs).

Up to 4 individuals will be invited for an all-expense paid trip to beautiful Lexington KY.

Apply here! rb.gy/3zk4cm

Shoutout to Sanders-Brown trainees as they met with legislators on Capitol Hill during the @alzassociation.bsky.social Advocacy Forum!
medicine.uky.edu/news/kentuck...
@ukresearch.bsky.social @universityofky.bsky.social @johnsonlab.bsky.social @bachstetterlab.bsky.social @mpmurphy.bsky.social

APOE4 reshapes the lipid droplet proteome and modulates microglial inflammatory responses Excess lipid droplet (LD) accumulation is implicated in various diseases, including Alzheimer's disease (AD), yet the mechanisms underlying this accum…

What does the APOE 'lipid droplet-ome' look like???

Check out our new paper to find out!
www.sciencedirect.com/science/arti...

Thanks to first authors @cassifriday.bsky.social and @iostephens.bsky.social

+help from Scott Gordon @morganti.bsky.social and @cohenlaboratory.bsky.social labs

Student Spotlight: Steve MacLean

Kudos to 𝐒𝐭𝐞𝐯𝐞 𝐌𝐚𝐜𝐋𝐞𝐚𝐧, a T32 in the @johnsonlab.bsky.social who does outstanding work!
medicine.uky.edu/centers/sbco...
@ukresearch.bsky.social @universityofky.bsky.social
#APOE

I cannot wait for @erinmgibson.bsky.social visit to Univeristy of Kentucky next week!!!! How lucky are we!!! 🤩🤩🤩

High-Resolution Spatial Profiling of Microglia Reveals Proximity Associated Immunometabolic Reprogramming in Alzheimers Disease Single-cell RNA sequencing has demonstrated that the presence of parenchymal amyloid plaques and intracellular hyperphosphorylated tau pathology is associated with distinctive (and possibly disease-dr...

New pre-print out:

www.biorxiv.org/content/10.1...

Surprise surprise 🤗, microglia proximity to AD pathology alters their immunometabolic signatures

Excellent work by Kai Saito and our team, along with our awesome collaborators Pete Nelson, @macauleylab.bsky.social, @johnsonlab.bsky.social

Nobel laureate: I owe America my success. Today, its scientific future is in danger | CNN Dr. Ardem Patapoutian says he watches “with deep sadness as the United States’ remarkable scientific enterprise, which took generations of hard work and national investment to build, faces a concerted...

As NIH and university funding in the US is dismantled and as this admin revokes international student visas for no reason…we need to make a stand. Thanks @ardemp.bskyverified.social for being vocal about what’s at stake! www.cnn.com/2025/04/09/h...

Lesley Golden is pictured receiving her award. To her right is Stacie Weninger. To her left is Takahisa Kanekiyo.

Aura Ramirez is pictured receiving her award. To her right is Stacie Weninger. To her left is Takahisa Kanekiyo.

Congratulations to #APOE25 Award Winners Lesley Golden, Ph.D., and Aura Ramirez, Ph.D. on their work to advance dementia science. #AAICAdvancements

ATP-sensitive potassium channels alter glycolytic flux to modulate cortical activity and sleep | PNAS Metabolism plays a key role in the maintenance of sleep/wake states. Brain lactate fluctuations are a biomarker of sleep/wake transitions, where in...

Our latest in PNAS! 🎉

ATP-sensitive potassium channels alter glycolytic flux to modulate cortical activity and sleep

Take home message?

KATP channels are metabolic sensors under circadian control that gate glycolytic flux, arousal, & sleep/wake transitions.

www.pnas.org/doi/10.1073/...

Freeze on NIH Grant Reviews Leaves Scientists Confused and Frustrated An unprecedented federal ban on scientific meetings halts research progress, sparking widespread concern across the scientific community.

Grateful to The Scientist for listening to my story and amplifying our concerns regarding bans on NIH communication and govt funding. www.the-scientist.com/freeze-on-ni...

new preprint!

www.biorxiv.org/content/10.1...

a characterization of APOE effects on the lipid droplet-ome (turns out you see a lot of "AD-related" proteins!)

first authors Cassi Friday & Isaiah Stephens + great collaborators Scott Gordon, @cohenlaboratory.bsky.social @morganti.bsky.social

For my first post, an invitation to join us in Miami! A lot of thing on ApoE and lipids are moving fast, catch up!

Abstract submission is now open!

😂 as long as we can use the term "study" loosely, I should be fine

@rikvanderkant.bsky.social @macauleylab.bsky.social hook it up, yo

can't have @morganti.bsky.social gloating about how he has more followers than me

Tal, can I join the APOE family? :)