Leigh-Ana Rossitto's Avatar

Leigh-Ana Rossitto

@lrossitto.bsky.social

just one brain studying other brains | UCSD BMS phd candidate studying brain-body crosstalk and nutrient signaling | @mitbrainandcog alum | 👩🏻‍🔬🌈 #FirstGen

37 Followers  |  75 Following  |  1 Posts  |  Joined: 08.11.2024  |  1.2862

Latest posts by lrossitto.bsky.social on Bluesky

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Reversible histone deacetylase activity catalyzes lysine acylation - Nature Chemical Biology Tsusaka et al. discover that histone deacetylases, which are well known to remove protein modifications, such as lysine acetylation and β-hydroxybutyrylation, can also reverse their chemical activity ...

I could not be more excited to have our lab's first story online where we report our discovery that HDACs ~reverse~ their activity to ADD acyl groups to lysine! We found this for our favorite ketone body, BHB, but this pathway controls other lysine modifications too!🧵

www.nature.com/articles/s41...

26.03.2025 14:02 — 👍 123    🔁 38    💬 10    📌 4

excited to see this out! congrats to your team!

03.12.2024 19:14 — 👍 1    🔁 0    💬 0    📌 0

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