Gonzalo Villanueva Martin

Sobre nuestro último estudio de metilación del ADN en arterias de pacientes de arteritis de células gigantes!! 👇🏼👇🏼

#ACR2025 is over! Grateful for the chance to dive deep into rheumatology, present Liyoung Kim’s poster, and meet so many inspiring scientists. Thanks to Maria Gutierrez-Arcelus for the support! See you next time! 👋
#Rheumatology #Immunology #ACR

Grateful for the chance to share my project in the poster session at #ASHG2025 in Boston and to learn from brilliant scientists.
Thanks to everyone who stopped by and sparked great discussions!

#Genetics #ASHG

We’d like to know too… #graphicmedicine #rheumsky #medsky

Genome‐wide DNA methylation study reveals specific signatures in the affected arterial tissue of giant cell arteritis patients Objectives Giant cell arteritis (GCA) is a large-vessel vasculitis, potentially causing complications such as blindness and strokes. This study aims to gain insights into the pathogenesis of GCA by ...

New paper just out (online first) in Arthritis & Rheumatology! 🎉

We mapped the epigenetic changes (DNA methylation) in GCA-affected arteries. Largest cohort to date; findings point to new pathways relevant to disease mechanisms 🧵

Read: doi.org/10.1002/art....

cc @ipblncsic.bsky.social

I’m excited to share my latest work with Marcella Franco, @mariagtac.bsky.social, and an amazing team. We used multi-omics to dissect key pathways of B cell activation, exploring gene programs, splicing, cell fates, and disease heritability in activated B cells.

www.medrxiv.org/content/10.1...

👏🏼👏🏼 Congratulations Gonzalo, great job! 🥳

Excited to share that our abstract for #EULAR was selected as one of the Top 10 Abstracts at EULAR 2025 by EMEUNET! 🙌🥰
Huge thanks to the committee, I’m truly honored!
Hope to see you in Barcelona! #EMEUNET #EULAR2025

An open letter to graduate students and other procrastinators: it’s time to write - Nature Biotechnology Nature Biotechnology - An open letter to graduate students and other procrastinators: it’s time to write

If I had an habit of terribly procrastinating writing, I’d totally recommend this feature from @naturebiotech.bsky.social. But, you know, for other people
www.nature.com/articles/s41...

Scientists standing in front of the Max Planck Institute for Molecular Genetics holding signs "#StandUpForScience"

#StandUpForScience👩‍🔬👨‍🔬📢Scientists at the Max Planck Institute for Molecular Genetics in Berlin, including our managing director, show solidarity with our colleagues in the US who are protesting against the attacks of the current US administration.
@standupforscience.bsky.social @maxplanck.de

Inolvidables los diálogos que escribía Asimov

🧬 Nuevo preprint de @goboru.bsky.social
El perfil de metilación del ADN en arteritis de células gigantes (GCA) revela alteraciones inflamatorias, vasculares y agotamiento de células T (SLAMF6, HAVCR2). Ampliando conocimiento en GCA! 📄 Para mas info: www.biorxiv.org/content/10.1...
#Vasculitis #GCA

🧬 New preprint by good friend @goboru.bsky.social!
DNA methylation profiling in giant cell arteritis (GCA) reveals altered inflammatory & vascular pathways, plus exhausted T cells (SLAMF6, HAVCR2). New insights into GCA pathogenesis!
📄 Read more in: www.biorxiv.org/content/10.1...
#Vasculitis #GCA

A few years ago, we started a fun 'Plot of the Month' competition. Each member made a plot with their data and shared the code to learn ggplot2 together. At the end of the month, we’d vote for the best one, and the winner kept a cute trophy for the next month. It made plotting way more fun!

A great example to start this section is Mal-ID (MAchine Learning for Immunological Diagnosis). A cool acronym for the method presented in this paper that uses machine learning to predict disease status from BCR & TCR repertoires. A great name for an impressive work! www.science.org/doi/10.1126/...

La ciencia progresa, pero no al mismo ritmo para todos #11F

Single-cell RNA sequencing is very important when studying gene expression. I found scDotPlot package developed by @laufer.bsky.social, and I think it could be a very useful tool to analyze and plot scRNA-seq data using R.

You can find more information in bioconductor.org/packages/rel...

Cross-trait GWAS in COVID-19 and systemic sclerosis reveals novel genes implicated in fibrotic and inflammation pathways AbstractObjectives. COVID-19 and systemic sclerosis (SSc) share multiple similarities in their clinical manifestations, alterations in immune response, and

New paper 🚨
What can COVID-19 teach us about systemic sclerosis (SSc)? 🤔
In our newly accepted paper in Rheumatology(Oxford) we explored the shared genetic component between COVID-19 and SSc to better understand their immune mechanisms and lung involvement 🧵👇
academic.oup.com/rheumatology...

It's always good to begin with a friendly reminder 📊

And final bonus fact: as a total nerd project, @javiml221098.bsky.social and I made a R package to use color palettes based on movies from Studio Ghibli in your plots 🔥

github.com/goboru/Ghibl...