Andrew Maclean

🚨 2-year post-doc position available in my lab. More details below. Please repost!

acrobat.adobe.com/id/urn:aaid:...

The essential host genome for Cryptosporidium survival exposes metabolic dependencies that can be leveraged for treatment An arrayed microscopy-based CRISPR screen revealed host genes affecting multiple infection phenotypes of the intracellular parasite Cryptosporidium. Hits in the host cholesterol biosynthesis pathway a...

Our paper has finally graduated from pre-print to peer-reviewed, pretty much unscathed, and is out now! www.cell.com/cell/fulltex...

📣 Open postdoc position in my lab to investigate how Toxoplasma acquires nutrients. Join me at the University of Edinburgh. Closing date 14th August. More details below ⬇️

elxw.fa.em3.oraclecloud.com/hcmUI/Candid...

Great opportunity with a great supervisor.

Nutrient acquisition by intracellular parasitic #protists --- #symbiosis #protistsonsky www.sciencedirect.com/science/arti...

Global diversity of soil-transmitted helminths reveals population-biased genetic variation that impacts diagnostic targets - Nature Communications This study analysed genetic data of soil-transmitted helminths from 27 countries, revealing diversity impacting molecular test accuracy and highlighting the need to adapt diagnostics for effective STH...

Great to be a (small) part of this beautiful new study on global diversity of soil transmitted #helminths from @stephenrdoyle.bsky.social and colleagues 🧪 www.nature.com/articles/s41...

Postdoc position open to investigate chronic Toxoplasma infection!

elxw.fa.em3.oraclecloud.com/hcmUI/Candid...

SOX9 plays an essential role in myofibroblast driven hepatic granuloma integrity and parenchymal repair during schistosomiasis-induced liver damage Author summary Mammalian infection with schistosome worms results in the deposition of parasite eggs in the liver, where they secrete organ damaging toxins. In response, the liver generates a cellular...

Delighted to share our paper on the role of SOX9 in liver #fibrosis and #granuloma formation during #schistosome infection - a really great collaboration over the past few years with the Piper Hanley lab! #ImmunSky 🪱🧪

dx.plos.org/10.1371/jour...

We hope to see you at MPM in Woods Hole this year (again, or for the first time): registration and abstract submission is now open!

Control of retrotransposon-driven activation of the interferon response by the double-stranded RNA binding protein DGCR8 The type I interferon (IFN) response is the main innate immune pathway against viruses in mammals. This pathway must be tightly regulated to prevent viral spread while avoiding excessive immune respon...

In our last preprint we identify endogenous dsRNAs capable of activating the interferon response. Could these be relevant to our understanding of DiGeorge syndrome (22qDS)?

In collaboration with @herassr.bsky.social and @heick.bsky.social labs

www.biorxiv.org/content/10.1...

Parasites need mitochondrial respiration to infect and spread. Effective anti-malaria and ani-toxoplasmosis drugs target respiratory complexes (e.g. atovaquone)!

But how do the parasite complexes work and how do drugs inhibit them?

Read Andrew Maclean and Alex Mühleip phenomenal work on this! 👇

Uncovering biomarkers for chronic toxoplasmosis detection highlights alternative pathways shaping parasite dormancy | EMBO Molecular Medicine imageimageDespite their clinical relevance, bradyzoite-filled cysts - the hallmark of chronic toxoplasmosis - are largely overlooked in current diagnostics. This study highlights bradyzoite serologica...

🧵 Ever wondered what Toxoplasma is doing in your brain years after that undercooked steak 🥩 or a sip of contaminated water? Turns out, it's been hiding in your brain 🧠and we finally have a way to spot it. New study just dropped in EMBO Molecular Medicine 👇
doi.org/10.1038/s443...

Happy to have contributed to this wonderful study about #Toxoplasma #supercomplex led by @macleanlab.bsky.social, @sheinerlab.bsky.social and Alex Mühleip. Parasite mitochondria never cease to amaze! Please go checkout 👇

Structure, assembly and inhibition of the Toxoplasma gondii respiratory chain supercomplex - Nature Structural & Molecular Biology Here the authors demonstrate that the assembly of mitochondrial respiratory supercomplex (III2–IV) from Toxoplasma gondii is critical for parasite fitness. They reveal the basis for cytochrome b inhib...

Happy to share our latest paper. Result of a great collaboration between @sheinerlab.bsky.social @oninopantsu.bsky.social and Alexander Mühleip’s new group.

www.nature.com/articles/s41...

Richard Wheeler keeping us all awake in the post-lunch session with a great talk about swimming in trypanosomatid parasites #EIDsymp25

Please consider applying for a post doc in our lab if you have bioinformatics and wet lab skills, and are interested in parasites!

elxw.fa.em3.oraclecloud.com/hcmUI/Candid...

Tissue atlas of Cryptosporidium parvum infection reveals contrasts between the natural neonatal calf model and laboratory mouse models Cryptosporidium is an apicomplexan parasite that causes diarrhoeal disease. The species C. parvum is zoonotic and causes significant morbidity and mortality for both humans and farm animals; most comm...

If you have ever wanted to know "Where is the gut is the parasite?" this pre-print is for you. 🐮 Led by Peyton, with thanks to our wonderful collaborators at @moredunfoundation.bsky.social Frank Katzer, @geordieparasit.bsky.social and EMs by @lemgruber.bsky.social www.biorxiv.org/content/10.1...

Defining the chromatin-associated protein landscapes on Trypanosoma brucei repetitive elements using synthetic TALE proteins Kinetoplastids, such as Trypansoma brucei, are eukaryotes that likely separated from the main lineage at an exceptionally early point in evolution. Consequently, many aspects of kinetoplastid biology ...

Exploring the chromatin proteome of Trypanosoma brucei repetitive elements (telomeres, centromeres, 70bp repeats, 177bp repeats) using TALEs. Another great collaboration with @allshire-lab.bsky.social

www.biorxiv.org/cgi/content/...

Please see the new tour de force from @danaaghabi.bsky.social PhD! We think that we have finally found the major Toxoplasma iron/zinc importer. Thanks to ID21 at the @esrf.fr, and help from UGs and the lab.
This is what I wanted to find when I started my lab, and thanks to Dana we have it!

ZFT is the major iron and zinc transporter in Toxoplasma gondii Transition metals, such as iron and zinc, are indispensable trace elements for eukaryotic life, acting as co-factors in essential processes ranging from respiration and metabolism to DNA replication. ...

New preprint alert 🔔🎉 We are so happy to share that our latest work “ZFT is the major iron and zinc transporter in Toxoplasma gondii” is now available online! www.biorxiv.org/content/10.1...

Professor Lilach Sheiner pictured in the lab holding the C.A. Wright medal in an open presentation case.

🏅 | @uofgsii.bsky.social's Professor Lilach Sheiner (@sheinerlab.bsky.social) was recently awarded the prestigious C.A. Wright Medal by the @bspparasitology.bsky.social for outstanding contributions to the discipline.

Congratulations, Professor Sheiner!

🔗 Full story: www.gla.ac.uk/schools/infe...

Fantastic opportunity with a great supervisor!

Thanks Andreia! The cats have adapted well to their new home 🐈‍⬛

Thanks Geoff!

Excited to start my lab at the University of Edinburgh studying sulfur metabolism in apicomplexan parasites. Kindly supported by an MRC Career Development Award.

Watch this space for job opportunities!

We're based in the Ashworth Laboratories, King's Buildings, University of Edinburgh. Photo shows the main staircase in the entrance to the Ashworth, stone steps from the 1920s, decorated with a series of bright, colurful banners depicting the science that's tackled in the building.

I'm very pleased to have two lab positions open this week, to join our team looking at immune regulation in infection and co-infection. We're especially interested in tissue-based immunity, cytokine regulation and immune metabolism. Join us! Postdoc (3y) and research technician (12mo) posts open.

🔊 Calling all parasite enthusiasts - come join us to study Toxoplasma and Plasmodium organelle biology 🔬
www.jobs.gla.ac.uk/job/research...

Thanks! Happy to have been a part of SPPIRIT and looking forward to see it grow and help more and more parasitology ECRs. Would definitely recommend getting involved!

Thanks Stuart!

Thanks Hannah!