Andrew Maclean

Cryptosporidium oocyst wall proteins are true components of the oocyst wall and COWP8 is not required for parasite transmission Author summary Infection with Cryptosporidium causes diarrhoea, which can be fatal for malnourished children or people who are immunocompromised. There is no vaccine or effective medicines available t...

Incredibly proud to share that our work on Cryptosporidium Oocyst Wall Proteins is published in
@PLOSPathogens
journals.plos.org/plospathogen...

Led by previous PhD student
@BacchettiRoss
and carried on by current PhD student, Sarah Stevens.

Endogenous structure of antimalarial target PfATP4 reveals an apicomplexan-specific P-type ATPase modulator Nature Communications - Here, the authors present the 3.7 Å cryoEM structure of native sodium efflux pump PfATP4 from Plasmodium falciparum, revealing a bound protein that they term...

Learn how our hunt for the native structure of top antimalarial target PfATP4🧂led to the discovery of PfABP, an unknown essential binding partner, out now! @natcomms.nature.com 👉 rdcu.be/eLRlH 🦠🔬❄️

A team effort led by @mehsehret.bsky.social & Anurag Shukla @akhilvaidya.bsky.social! #cryoEM #malaria

Excited to share our new paper!
Tepsin and AP4 mediate transport from the trans-Golgi to the plant-like vacuole in Toxoplasma gondii.

A great collaboration between the Meissner, Jiménez-Ruiz, and Dacks labs 🙌

#Toxoplasma #Apicomplexa #Golgi #CellBiology #Parasites

The Matthews Lab | Biology The Matthews Lab

We have a 3+ year post doc available in our lab to study trypanosome transmission and virulence. Combined wet lab and bioinformatics expertise preferred. Please apply via the HR link (elxw.fa.em3.oraclecloud.com/hcmUI/Candid...). Find out more about us in the link below.

Delighted to share this story from my PhD! 🎉 🪱

From nutrient acquisition to drug resistance, membrane transport is especially important for intracellular parasites! This review will help you stay up-to-date on the latest transport research for crypto/malaria/toxo: www.sciencedirect.com/science/arti...

Graphic abstract of paper showing the identification of HpBoRB, a worm protein which binds RELM-beta

Latest McSorley lab paper is out! Led by Vivien @vshek.bsky.social, this is a story about the immunomodulators from H. polygyrus bakeri (Hpb), and how their analysis led to the identification of HpBoRB, a secreted protein which binds host RELM-beta www.sciencedirect.com/science/arti...

[We are Hiring!]

The Weiss Lab at Albert Einstein College of Medicine (NY) is hiring a Postdoc Scientist to explore the Toxoplasma gondii cyst wall using XL-MS, Split TurboID, & U-ExM.

This project aims to unlock new strategies for treating toxoplasmosis.

DM for more info!

The Plant Shape Lab is hiring! Are you interested in supporting cutting edge cereal research? We are looking for an enthusiastic and dedicated technician to join us for 2 years, setting up and running cereal transformation. Find out more, and apply here: elxw.fa.em3.oraclecloud.com/hcmUI/Candid...

Hostbusters: SPPIRITed to Roslin Bringing together ECR parasitologists from across Scotland to network and showcase their science.

📢 7 weeks to go until our SPPIRIT symposium

A fantastic opportunity for ECR parasitologists across Scotland to network and showcase their research.

🗓️ 31 October 2025 | 📍 Roslin Institute, Edinburgh
🎟️ Free to attend → tinyurl.com/3yzjnm5h

Secure your spot today!

Save the dates!! @bspparasitology.bsky.social Spring Meeting 2026 will be in Bonnie Glasgow! 7-9 April 2026, with a drinks reception in Glasgow City Chambers on the 6th of April 2026!
Keep an eye on the BSP website for registration and abstract submission!
Logo by @shannaraeilean.bsky.social! 🦟

Don't miss the chance to learn from an industry expert in drug discovery and connect with the Tryps Club community! 🌍✨

Assembly of the mitochondrial outer membrane module of the trypanosomal tripartite attachment complex Author summary Mitochondria are essential for nearly all eukaryotes. This requires proper segregation of the organelles and their genomes to the daughter cells during cell division. For Trypanosomes a...

The trypanosomal TAC is required for mitochondrial DNA segregation. We provide insight into TAC assembly: one of the most extreme sorting event for any mitochondrion.
Congratulations to Philip, Salome and Bernd
#mitochondria #mtDNA #Trypanosoma
journals.plos.org/plospathogen...

IndAc Conference - SULSA

SULSA is running an Industry Academia conference on 28th & 29th October.
Looks fantastic for researchers working in Scotland- particularly good for students interested in learning more about industry & working on skill development!
sulsa.ac.uk/indac/

Targeted CRISPR screens reveal genes essential for Cryptosporidium survival in the host intestine - Nature Communications Cryptosporidium is an important threat to public health, yet it lacks a robust genetic toolkit. Here, Watson et al. introduce a targeted CRISPR-based screening method to identify parasite genes that a...

Now available in a polished format! An important step toward accelerated functional genomics for the Cryptosporidium parasite. Brought to you by the incomparable @lucy-watson.bsky.social
www.nature.com/articles/s41...

Only one week left until SPPIRIT Forum meeting! Join us to discuss recent work on mosquito tissue ultrastructure-expansion microscopy for malaria research, and ask questions to the 1st author, @benliffner.bsky.social, who will join us!
For meeting link fill in: tinyurl.com/3j5ewezv

🚨NEW PAPER🚨 We've already shown mosquito infections vary by time-of-day, here we test whether infection of mice FROM mosquitoes vary in a rhythmic manner. We test this in untreated & drug treated mice as some fitness consequences are only apparent in stressful environments doi.org/10.1186/s130...

Leishmania major chromosomes are replicated from a single high-efficiency locus supplemented by thousands of lower efficiency initiation events DNA replication initiates at genome sites termed origins. Previous origin mapping approaches in the populations of the protozoan parasite Leishmania m…

We’re pleased to share our new study, led by @jezieldamasceno.bsky.social, that used long-read, single molecule sequencing to reveal the full (?) picture of Leishmania DNA replication. Thanks, Mike Boemo and helpful reviewers @uofgsii.bsky.social

www.sciencedirect.com/science/arti...

I am recruiting for a postdoc that wants to work on an exciting project on gut macrophages, TGFb signalling, and colon cancer! Please see the link for details - elxw.fa.em3.oraclecloud.com/hcmUI/Candid...

Hi there! Our group at LMU Munich is hiring a postdoc to work on Toxoplasma and Plasmodium.
Start: from Oct 1, 2025 | Location: Munich, Germany
1-year contract with extension possible
Apply by Aug 31: bit.ly/LMUpostdoc
Contact: elena.jimenez@lmu.de

My attempt to become a professor was unsuccessful again but the diplonema tagging paper is now published in Open Biology. royalsocietypublishing.org/doi/10.1098/...

🚨 2-year post-doc position available in my lab. More details below. Please repost!

acrobat.adobe.com/id/urn:aaid:...

The essential host genome for Cryptosporidium survival exposes metabolic dependencies that can be leveraged for treatment An arrayed microscopy-based CRISPR screen revealed host genes affecting multiple infection phenotypes of the intracellular parasite Cryptosporidium. Hits in the host cholesterol biosynthesis pathway a...

Our paper has finally graduated from pre-print to peer-reviewed, pretty much unscathed, and is out now! www.cell.com/cell/fulltex...

📣 Open postdoc position in my lab to investigate how Toxoplasma acquires nutrients. Join me at the University of Edinburgh. Closing date 14th August. More details below ⬇️

elxw.fa.em3.oraclecloud.com/hcmUI/Candid...

Great opportunity with a great supervisor.

Nutrient acquisition by intracellular parasitic #protists --- #symbiosis #protistsonsky www.sciencedirect.com/science/arti...

Global diversity of soil-transmitted helminths reveals population-biased genetic variation that impacts diagnostic targets - Nature Communications This study analysed genetic data of soil-transmitted helminths from 27 countries, revealing diversity impacting molecular test accuracy and highlighting the need to adapt diagnostics for effective STH...

Great to be a (small) part of this beautiful new study on global diversity of soil transmitted #helminths from @stephenrdoyle.bsky.social and colleagues 🧪 www.nature.com/articles/s41...

Postdoc position open to investigate chronic Toxoplasma infection!

elxw.fa.em3.oraclecloud.com/hcmUI/Candid...

SOX9 plays an essential role in myofibroblast driven hepatic granuloma integrity and parenchymal repair during schistosomiasis-induced liver damage Author summary Mammalian infection with schistosome worms results in the deposition of parasite eggs in the liver, where they secrete organ damaging toxins. In response, the liver generates a cellular...

Delighted to share our paper on the role of SOX9 in liver #fibrosis and #granuloma formation during #schistosome infection - a really great collaboration over the past few years with the Piper Hanley lab! #ImmunSky 🪱🧪

dx.plos.org/10.1371/jour...