Samantha Jensen

NK cells share a universal signature of memory with B and T cells. Come to my presentation at AAI to find out more.

Sunday April 4th 9:30am Room 316C
#AAI2025 #NKcells #ImmuneMemory

Follow our new podcast for more Mucosal Immunology - #MucosalMondays, coming to you the last Monday of every month.

Everyone should contact their senators/representatives to advocate for the NIH. Point out things like below. And like the fact that all new drugs have their point origin in NIH-funded research (then developed by Pharma/Biotech). The real impact of NIH has been lost in the noise of political BS

Top read articles in 2024: Single-cell atlas of the small intestine throughout the human lifespan demonstrates unique features of fetal immune cells. www.mucosalimmunology.org/article/S193...

Different effects of fatty acid oxidation on hematopoietic stem cells based on age and diet Morrison and colleagues show long-chain fatty acid oxidation has context-dependent effects on hematopoietic stem cells (HSCs). It is dispensable for HSC function in young mice. It becomes necessary for normal HSC function and hematopoiesis in older mice. A high-fat diet increases fatty acid oxidation, and this impairs HSC function.

Long-chain fatty acid oxidation (FAO) is dispensable for hematopoietic stem cells in young mice, while crucial for HSCs in old mice. But then too much FAO is detrimental for HSCs.

Fatty diet makes us unhealthy to the core...literally, our bone marrow…

www.cell.com/cell-stem-ce...

Neanderthal ancestry through time: Insights from genomes of ancient and present-day humans Gene flow from Neanderthals has shaped genetic and phenotypic variation in modern humans. We generated a catalog of Neanderthal ancestry segments in more than 300 genomes spanning the past 50,000 year...

A new genomic study in Science encompassing more than 300 genomes spanning the last 50,000 years has revealed how a single wave of Neanderthal gene flow into early modern humans left an indelible mark on human evolution. scim.ag/4gkMvpz

Bacterial and host fucosylation maintain IgA homeostasis to limit intestinal inflammation in mice - Nature Microbiology Bacterial and host fucosylation protect against colitis by maintaining the IgA B cell response in the mouse gut.

Bacterial and host fucosylation maintain IgA homeostasis to limit intestinal inflammation in mice
www.nature.com/articles/s41...
@naturemicrobiol.bsky.social

Tissue-specific ILC progenitors governing distribution, developmental kinetics, and gene expression exist in human fetal development, including CD34+RORγt+Eomes- & CD34+RORγt+Eomes+ progenitors in fetal intestine
doi.org/10.1002/eji....
@eurjimmunol.bsky.social @jakmic.bsky.social

IL-23R is a senescence-linked circulating and tissue biomarker of aging
www.nature.com/articles/s43...
@natureaging.bsky.social

Toufic gave a great presentation today on his recently published nature paper characterizing the spatial landscape of the gut. Everyone should check it out!

ILC2 are a non-redundant source of IL-5 required for development and function of murine B1 cells
www.nature.com/articles/s41...

Fungal symbiont transmitted by free-living mice promotes type 2 immunity - Nature Kazachstania pintolopesii is a highly prevalent fungal symbiont that can trigger type 2 immunity and influence the composition of the gut mycobiome, as well as immune and disease phenotypes.

Fascinating new paper about how commensal #fungi can promote #type2 responses in mice, a process involving fungal induction of #IL-33 🍄 🧪 #ImmunoSky www.nature.com/articles/s41...

Dietary zinc deficiency promotes Acinetobacter baumannii lung infection via IL-13 in mice Nature Microbiology - Increased IL-13 drives increased bacterial dissemination and mortality following Acinetobacter baumannii lung infection of zinc-deficient mice and can be countered by...

SO EXCITED to share our recent work on dietary zinc deficiency worsening Acinetobacter baumannii pneumonia, out today with @natureportfolio.bsky.social!! Surprisingly, this is due at least in part to the allergic-type cytokine IL-13. SharedIt link: rdcu.be/d0h4h Eat your zinc rich foods! 🦪🫘🧀🥩🥜

PIEZO-dependent mechanosensing is essential for intestinal stem cell fate decision and maintenance Stem cells perceive and respond to biochemical and physical signals to maintain homeostasis. Yet, it remains unclear how stem cells sense mechanical signals from their niche in vivo. In this work, we ...

Fascinating🤩
www.science.org/doi/10.1126/...

What I’ve learned so far is that mechanosensing is important pretty much everywhere in our body.

We are constantly “pulled” downwards by the gravity. I wonder what would happen if the entire embryogenesis and fetal development occurred in zero gravity.

Can you please add me! Thank you!