Lung structural cells are altered by influenza virus leading to rapid immune protection following re-challenge @natcomms.nature.com www.nature.com/articles/s41...
02.08.2025 03:29 โ ๐ 8 ๐ 1 ๐ฌ 0 ๐ 0
Probabilistic migration events drive transient tissue residency of lymphocytes during homeostasis
Tissue-resident lymphocytes form a phenotypically and functionally distinct analog to the corresponding circulatory lymphocyte populations. Residential CD8 T cells, in particular, are identified as having prolonged residence in the tissues and key functions in recall responses at tissue-environmental interfaces, although the dwell time in individual tissues has yet to be resolved. Residential CD4 T cells, regulatory T cells, B cells, and NK cells have been demonstrated to share phenotypic properties with residential CD8 T cells, but the migratory kinetics are even more poorly defined. Here we used probabilistic modelling on a large parabiosis dataset, covering multiple time-points and tissues, to calculate migration kinetics and dwell times of multiple lymphocyte subsets across a diverse set of tissues. Markov chain modelling identified distinct cell type-specific and tissue-specific residency patterns. The liver and gut were prone to prolonged residency compared to other tissue types, and a hierarchy of residency was observed with CD8 T cells and NK cells demonstrating longer residency than CD4 conventional T cells and regulatory T cells, which in turn resided in tissues longer than B cells. With few exceptions, however, average residency was at least an order of magnitude shorter than the life-span of the mouse, indicating a more dynamic form of steady-state tissue residency than usually assumed. Together these data provide a comprehensive model of a pan-tissue shared program in lymphocyte tissue residence, as well as identifying cell type- and organ-specific modification of the migratory kinetics. ### Competing Interest Statement The authors have declared no competing interest. Wellcome Trust, https://ror.org/029chgv08, 222442/Z/21/Z European Research Council, TissueTreg
I'm excited about a new @biorxivpreprint.bsky.social story that just went live! This one takes a #computational #immunology approach to understanding #tissueresident lymphocytes. The story highlights the extra value mathematical modelling can bring to biology. ๐งต1/10
www.biorxiv.org/content/10.1...
09.07.2025 08:17 โ ๐ 66 ๐ 22 ๐ฌ 1 ๐ 3
Our new review article led by Jordan Kramer:
Platforms for studying cellโcell recognition by immune cells
onlinelibrary.wiley.com/doi/10.1111/...
31.05.2025 08:54 โ ๐ 19 ๐ 6 ๐ฌ 1 ๐ 0
Dear uLIPSTIC users,
We have been getting reports that, under some more inflammatory settings like TB or chronic LCMV infection, uLIPSTIC-expressing lymphocytes adoptively transferred into cre-negative uLIPSTIC hosts may be rejected at later timepoints (>1 wk).
29.05.2025 19:13 โ ๐ 27 ๐ 15 ๐ฌ 1 ๐ 0
There are still a few places left for this major @oxfordcancer.bsky.social fixture. We are keeping registration open until places are filled so sign up now!
20.05.2025 15:58 โ ๐ 5 ๐ 2 ๐ฌ 0 ๐ 1
Model figure - in EAC cancers, as chromosomal instability (CIN) increases, we found that a CIN-driven cGAS-dependent axis drives myeloid directed chemokine expression and recruitment of tumor-favoring myeloid populations
Incoming - new preprint alert from the Parkes lab led by @brunobeernaert.bsky.social Full bluetutorial follows! 1/ 11 www.biorxiv.org/content/10.1...
12.05.2025 12:08 โ ๐ 47 ๐ 19 ๐ฌ 1 ๐ 2
Macrophages direct location-dependent recall of B cell memory to vaccination
Vaccines generate long-lived plasma cells and memory B cells (Bmems) that may re-enter secondary germinal centers (GCs) to further mutate their B cellโฆ
Happy #DayofImmunology! Congrats @ramadhenni.bsky.social & Alexandra Carey Hoppรฉ it's out (finally!) @cp-cell.bsky.social! Incredibly grateful to co-leads @mlmunier.bsky.social, Vanessa Venturi & Tony Kelleher & all brilliant folks @garvaninstitute.bsky.social & Kirby Inst. for fantastic collab! ๐งต
29.04.2025 13:20 โ ๐ 36 ๐ 13 ๐ฌ 3 ๐ 3
DPhil in Cancer Science
We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this messageโฆ
Last chance to apply for our 2025 DPhil in Cancer Science Programme!
๐ฅผ We are open to applications from Medical Undergraduates
๐ We also have 3 GSK-Oxford DPhil studentships available.
๐ข Deadline: Noon 25th April.
Apply below โฌ๏ธ @medsci.ox.ac.uk
www.cancer.ox.ac.uk/study#how-to...
23.04.2025 09:19 โ ๐ 1 ๐ 2 ๐ฌ 0 ๐ 0
Now published @cp-iscience.bsky.social
Work lead by David Lecky & Lozan Sheriff in collaboration with @therad-lab.bsky.social and @cameron-wraith.bsky.social showing how IFNg augments T Cell receptor signal strength to enhance type 1 Regulatory T (Tr1) cell development
www.cell.com/iscience/ful...
11.04.2025 07:21 โ ๐ 38 ๐ 7 ๐ฌ 2 ๐ 1
TBK1 and IKKฮต prevent premature cell death by limiting the activity of both RIPK1 and NLRP3 death pathways
TBK1 and IKKe prevent premature cell death by limiting the activity of multiple death pathways in myeloid cells.
The loss of TBK1, or both TBK1 and the related kinase IKKฮต, results in uncontrolled cell deathโdriven inflammation. We show that TBK1/IKKฮต prevent premature cell death by limiting the activity of multiple death pathways in myeloid cells. www.science.org/doi/10.1126/...
07.03.2025 20:49 โ ๐ 51 ๐ 22 ๐ฌ 7 ๐ 4
Adaptive immunity in barrier tissues
Immune responses lie at the heart of almost every aspect of human health, including host responses to infection, autoimmunity, cancer, metabolism and aging. While adaptive immune responses by B and Tโฆ
๐ฆ ๐ฌ We are very excited to organize an EMBO workshop on Immunity in Barrier Tissues with Carolyn King! @immunologyking.bsky.social
๐ Where: Basel, Switzerland
๐
When: 26thโ29th August 2025
๐ Registration deadline: 30th May 2025
Check out the program and details ๐
#EMBOBarrierTissues @embo.org
25.02.2025 08:33 โ ๐ 34 ๐ 16 ๐ฌ 1 ๐ 2
Research Assistant (177885)
We are looking for a Research Assistant with a background in immunology/neurobiology to join the interdisciplinary laboratory of Dr Frรคnze Progatzky at the Kennedy Institute.
๐จ We have TWO exciting open positions in our lab! ๐จ
We are looking for talented, highly motivated, and collaborative individuals to join our dynamic team as:
๐ฌ Research Assistant
www.kennedy.ox.ac.uk/jobs/researc...
๐ป Bioinformatics Postdoc
www.kennedy.ox.ac.uk/jobs/bioinfo...
๐ข Please share!
24.02.2025 11:35 โ ๐ 124 ๐ 77 ๐ฌ 1 ๐ 5
Intravital imaging of pulmonary lymphatics in inflammation and metastatic cancer @jem.org @simoncleary.bsky.social
doi.org/10.1084/jem....
20.02.2025 02:37 โ ๐ 27 ๐ 9 ๐ฌ 0 ๐ 0
Meningeal regulatory T cells restrain local interferon-ฮณโproducing lymphocytes, thereby safeguarding parenchymal brain homeostasis
@sciimmunology.bsky.social @mmr2.bsky.social
www.science.org/doi/10.1126/...
28.01.2025 18:06 โ ๐ 20 ๐ 6 ๐ฌ 1 ๐ 0
Tissue-resident memory CD8 T cell diversity is spatiotemporally imprinted - Nature
Profiling of the location and transcriptome of tissue-resident memory CD8 T cell formation at single-transcript resolution finds regionalized signalling as the basis of immune diversity in t...
It turns out the immune system is playing 4D chess while we thought it was just playing checkers. Using #spatialtranscriptomics from @10xgenomics.bsky.social and @vizgen.bsky.social we were able to peek into the secret lives of tissue resident T cells in the gut as they form after infection 1/n
22.01.2025 17:37 โ ๐ 68 ๐ 26 ๐ฌ 4 ๐ 2
The OT-I TCR is often criticised as being very high-affinity and displaying unusual behaviour compared to other TCR transgenics. New work from @tcell.bsky.social shows this might not be the case. Will I still use OT-I and all the wonderful tools associated with it? Yes I will!
16.01.2025 10:34 โ ๐ 11 ๐ 3 ๐ฌ 0 ๐ 0
MuSpAn: A Toolbox for Multiscale Spatial Analysis
The generation of spatial data in biology has been transformed by multiplex imaging and spatial-omics technologies, such as single cell spatial transcriptomics. These approaches permit a detailed mapp...
FYI for anyone interested in MuSpAn - we've updated the preprint this week with the full SI. Now featuring more examples of how various different spatial metrics can be strung together in order to make spatial pipelines focussed on specific biological questions!
www.biorxiv.org/content/10.1...
09.01.2025 17:59 โ ๐ 13 ๐ 7 ๐ฌ 1 ๐ 0
Two studies published in @nature.com today showing that Tpex-like cells develop independent from acute or chronic infection
#Tpex
www.nature.com/articles/s41...
09.01.2025 08:33 โ ๐ 8 ๐ 4 ๐ฌ 1 ๐ 0
Serial intravital microscopy reveals temporal dynamics of autoreactive germinal centers in the spleen
doi.org/10.1101/2025...
09.01.2025 02:20 โ ๐ 5 ๐ 4 ๐ฌ 0 ๐ 0
Thank you!
05.01.2025 16:41 โ ๐ 0 ๐ 0 ๐ฌ 0 ๐ 0
I'd love to be added if there is still some room ๐โโ๏ธ
05.01.2025 11:02 โ ๐ 1 ๐ 0 ๐ฌ 0 ๐ 0
Thank you for sharing!
04.01.2025 20:15 โ ๐ 0 ๐ 0 ๐ฌ 0 ๐ 0
oops, @naturecomms.bsky.social !
04.01.2025 20:11 โ ๐ 0 ๐ 0 ๐ฌ 0 ๐ 0
Postdoc at @BelkaidLab | PhD roots in @iannaconelab ๐ feminist, LGBTQIA+ soldier, bookworm, 80s flowing in my veins
Principal Scientist Bioinformatics @ Gilead Sciences, Oxford UK
Researchers at the University of Birmingham, Centre for Liver and Gastrointestinal Research, UK
Senior Scientist, Bioinformatics @ Gilead Sciences | Bioinformatics | Computational biology | Fibrosis | Immunology | Cardiovascular disease
https://scholar.google.co.uk/citations?hl=en&user=QgA-ngcAAAAJ&view_op=list_works&sortby=pubdate
Incoming Group Leader of Cancer Immunology
University of Oxford
MD/PhD โ Postdoc Brigham/Harvard Med
Immunology. Kidneys. Autoimmune Disorders. Basketball. Jazz.
50% of the @immunoboys.bsky.social
Postdoctoral fellow @UofT Immunology | Currently @EpelmanLab | Former postdoc @DunnLab | Ph.D. @GruenheidLab and @krawczykLab | B.Sc Mcgill University | Dendritic cells, Sex differences, Cardiac immunology, Nanoplastics
๐ฌ๐ง in ๐บ๐ฒ. Immunologist studying glioblastoma at Duke. Grimsby Town fan. Crochet & knitting enthusiast. She/her.
Husband, father & son | neonatologist & immunologist | Colombiano & Latinx
Associate Professor & Educator @UofT Immunology | iNKT cells | MAIT cells | T cells | microbiota | IBD | Cancer | ๐ซ๐ท๐จ๐ฆ
Studying fetomaternal tolerance since 2022 at Memorial Sloan Kettering Cancer Center.
http://therizzutolab.com
Scientist and Deputy Editor, Cell at Cell Press
All things science with a love for #microbes, #immunology & #metabolism #sciencesky #womeninSTEM - Opinions and posts are my own. ๐บ๐ธ๐ฎ๐ณ
https://www.cell.com/cell/editors-and-staff
Scientist, Dog mom, Sushi Queen, and New Yorker
Naiklab.com
Views are my own
Our lab investigates the cellular and molecular mechanisms of tumor initiation, progression, metastasis and therapy resistance using intravital microscopy.
An inflammatory sciences centre @ox.ac.uk @ndorms.bsky.social. Bridging discovery and clinical research, focused on the biology of tissue health and chronic disease.
Postdoc at WEHI, Australia ๐ฉ๐ผโ๐ฌImmunologist & T cell enthusiast ๐ฌ๐งซ๐ฆ Big fan of lymph nodes, microscopy and an unexpected key change๐โจ she/her
The Canadian Society for Immunology strives to support #immunology research and education across Canada ๐ฌ๐จ๐ฆ
Account run by the CSI Trainee Engagement Committee
https://www.csi-sci.ca
Postdoc in Oxford working with spatial and single-cell proteomics
Our mission is to apply bold, collaborative, translational science to advance our mechanistic understanding of human autoimmunity. Proudly part of the @coltonconsortium.bsky.socialโฌ.
Learn more: www.med.upenn.edu/penncoltoncenterautoimmunity
