Hassan Fazilaty

New perspective in selecting cancer treatment can provide more precision by targeting resurrect embryonic genetic (oncoembryonic) programs that fuel malignancy, metastasis, immune suppression, and therapy resistance.

#oncoembryology #cancerresearch #precisionmedicine

Unlocking oncoembryonic programs for clinical advances in cancer therapy Click on the article title to read more.

It is time to view cancer as “wounds that do not heal”, and act accordingly!

In this short piece with Tosca Dalessi, we explore how oncoembryonic programs could reshape precision therapy:

— Less collateral damage
— Prevent resistance
— Better models for discovery

🔗 doi.org/10.1002/ctm2...

#Postdoc position alert 🚨My friend and colleague Iros Barozzi is offering a fully funded postdoc postion studying tumor heterogeneity using functional genomics 🧬 and single cell omics 🧑‍🔬. great lab and great collaborators :) join our institute in beautiful Vienna.

Loss of colonic fidelity enables multilineage plasticity and metastasis - Nature The chromatin-remodelling enzyme ATRX and the transcription factor HNF4A are identified as pivotal regulators of colonic epithelial identity, with roles in metastasis in colorectal cancer.

Kudos to Cammareri and co. of Myant lab for unveiling how ATRX & HNF4A gatekeep colonic identity—lose ATRX, and cells go rogue, fueling CRC metastasis. A crucial step toward understanding and targeting plasticity in #ColorectalCancer! #CancerResearch

www.nature.com/articles/s41...

Fantastic work, congratulations Claudio and the team!

Congratulations @christophschneider.bsky.social and to the team!

Excerpt from article by Prof Kelly-Ann Allen: The index could reflect good science practices — for instance, by recognizing replication studies. And public reach could be measured in terms of open-science prac- tices — data-sharing, pre-registering protocols and commu- nicating through podcasts, blogs and media contributions. In some fields, publishing in practice-based journals could be rewarded to ensure that research reaches profes- sional communities. Similarly, editorial and peer-review work for these journals — and work for scientific societies, regardless of prestige — could be valued. Ultimately, the full list of metrics should be decided by the academic community, reflecting a collective vision for a healthier workplace. Funding bodies and institutions could then incorporate the index into their evaluation criteria, providing both the infrastructure and incentives for adoption. Many of the metrics are already tracked in existing data repositories, but improved systems to collect and amalgamate the data are needed. The index should remain dynamic and evolving, allowing new ways to evaluate and measure other desirable work- place attributes to emerge over time — work–life balance, for instance, or a positive teaching culture.

Move beyond ‘publish or perish’ by measuring behaviours that benefit academia

Perspective in #Nature 🧪 suggesting a new "G+ index" — G representing generosity, giving and other ‘good things’ in academia

Wouldn't this be great 🤔

By Prof. Kelly-Ann Allen

www.nature.com/articles/d41...

Tumor “age” in early-onset colorectal cancer The incidence of early-onset colorectal cancer (EO-CRC) is surging, and by 2030, one-third of all CRCs will occur before the commonly recommended screening age of 50 years. The time required for EO-CR...

By 2030, 1 in 3 colorectal cancers will occur before age 50! The speed at which early-onset colorectal cancer metastasizes remains unclear, but understanding its biology is urgent to prevent a looming cancer epidemic.

www.cell.com/cell/fulltex...

Today is #WorldCancerDay, a day to reflect and push for progress.

Cancer affects millions, but research and innovative treatments are changing lives. Every discovery, every breakthrough, and every act of support brings us closer to a future where cancer is no longer a life-threatening disease.

Congratulations Bahar and team!

Eosinophils restrict CRC metastasis by inhibiting pro-tumorigenic SPP1+ macrophage differentiation Eosinophils, traditionally associated with allergic responses, have emerged as critical immune modulators in colorectal cancer (CRC). Here, we reveal that eosinophils actively shape the tumor microenv...

Exciting new findings reveal eosinophils as key allies in the fight against colorectal cancer by blocking tumor spread.

Great work by Kristina Handler, Deeksha Raju, Alessandra Gurtner & team lead by the amazing Isabelle Arnold! Honored to be a part of this study.
www.biorxiv.org/content/10.1...

Reflections on Advances in Cancer Research in 2024 There have been many impactful advances in basic, translational, and clinical cancer research in 2024. An important mission of Cancer Discovery is to ensure the timely dissemination of innovative ways...

Honored that our story on Plexin B2 was mentioned alongside these amazing studies! 🥰
aacrjournals.org/cancerdiscov...

Great, would love to join as well, thanks!

A growth, and then a metastasis, of cancer researchers (two starter packs)...

by @johannajoyce.bsky.social

bsky.app/starter-pack...

bsky.app/starter-pack...

An oncoembryology approach uncovers SoxC-driven regulation of colon development and cancer Reactivated embryonic programs are associated with cancer progression, yet their role and regulatory mechanisms remain poorly understood. In this study, we introduce ‘oncoembryology,’ an approach that...

Hello friends!
Thrilled to join the Bluesky community! My research delves into the connections between embryonic development and cancer, using a novel approach we call 'oncoembryology'.

Check out our latest preprint: www.biorxiv.org/content/10.1...

And our review: www.nature.com/articles/s41...