Ashish Sharma

Renalism: The failure to perform appropriate diagnostic/ therapeutic interventions in patients with CKD due to concern about risk of AKI #Nephpearls #NephSky

👉🏼 pubmed.ncbi.nlm.nih.gov/15339996/

PISCES VA

And the causes of death are heart failure, sudden death, infections- how would fish oil impact those in such a huge way?

It is all a bit puzzling

See @nephroseeker.medsky.social beautiful VA till then

#KidneyWk

Yeah - fish oil having such a huge effect is a bit odd. We will be going deep into it on a future #NephJC to understand this.

Dialysis is tricky - statins don’t work as well, beta-blockers perhaps do, and the pathophysiology is different.

#NephJC #KidneyWk

Kidney Week in Houston: Day 2 — NephJC in this edition: Fish Oil, GBD, Flozination meta-analysis, CHW intervention in Hispanic/Latino patients, and much more

Missing all the overwhelming amount of science coming out of #KidneyWk?

The #NephJC crew has got you covered

Day 2 edition www.nephjc.com/news/kidneyw... via @nephroseeker.medsky.social & moi

LBRO

And in the evening
- a CAR T in refractory SLE
- a PKD trial
- increasing PD in Vets
- Povetacicept in IgA
- TESTING Longterm term data
- what do the AHA/ACC BP guidelines mean?

#KidneyWk

LBCT session

Today’s LBCTs and late breaking science!

Morning:
- an Alport trial!
- Telitacicept
- REGENCY biopsy data
- Vitamin R updated in Membranous
- another sibeprenlimab slice
- Balcinrenine + Dapa in CKD

#KidneyWk

Shocking first high impact trial of the day. Fish oil reduces CV events in dialysis patients! #Pisces #kidneywk

Simultaneous pub in NEJM

www.nejm.org/doi/full/10....

Was listening to nephjc freely filtered episode of ACHIEVE trial just the other day. Of all the things we've tried in HD and failed, and now fish oil does the trick??? @kidneyboy.bsky.social @hswapnil.medsky.social

Cockcroft Gault, the latest from the trenches A few weeks ago I had to check the dose of pregabalin (Lyrica) in kidney failure and found myself in the drug label (this is what happens when you fact check ChatGPT) and saw that they included the…

It’s 2025 and we’re still dosing drugs like it’s 1976.

The saga of Cockcroft–Gault, FDA inertia, and the slow evolution of renal dosing equations.

🧮 pbfluids.com/2025/10/cock...

🚀🖥️ The @nikttaskforce.bsky.social Dashboard Prototype is Live!

🔗 Explore it here: www.niktt.com.au/data-dashboard

📢 We would like to know what you think-please provide feedback here: forms.cloud.microsoft/pages/respon...

📌 Note: The dashboard is best viewed on a desktop computer

NephJC Shorts: Should we Screen for Kidney Disease? — NephJC Should we screen for CKD?

should we screen for CKD in the general population?

Finally, flozins, finerenone and GLP1s allow a good cost-effectiveness case

www.nephjc.com/news/2025/7/... for #NephJC shorts

Time to stop just being dialysis-ologists and flozinate, glipinate!

#NephSky

Algorithmic approach to Peritoneal Dialysis (PD) Catheter OUTFLOW FAILURE
#Nephpearls #NephSky

👉🏼 pubmed.ncbi.nlm.nih.gov/20630641/

CKD-MBD still undefeated in its ability to generate negative trials!

This study sounds like a three-foot putt. How can sevelamer not be better at reducing propensity toward calcification? I don't know but P=0.8.

HELLO I HAVE A ROUTINE CONSULT THEY CAN BE SEEN IN THE MORNING JUST WANNA LET YOU KNOW ABOUT IT NOW AT MIDNIGHT OKAY THANKS GOODNIGHT

consulted for a potassium of 5.5 on a patient who recently started both entresto and aldactone. i am a salieri in a world with no mozarts.

Work smarter, not harder!

A low renin with concurrent use of ACEi/ARB is almost certainly some shade of Primary Aldosteronism.

Either way, aldosterone-directed therapy is very likely to provide major clinical benefits

www.ahajournals.org/eprint/TUS6C...

FRESH-UP Trial #ACC25 #medsky

RCT comparing liberal vs restricted fluid intake (≤1500 ml/d) in 504 pts with stable chronic HF

🌊No difference in status health quantified by Kansas City Cardiomyopathy Questionnaire at 3 mths
🌊 More thirst distress with restriction

www.nature.com/articles/s41...

People look at this and scream about getting an AV accesses because of the dramatically lower infection rate, but 1.2 infections per 100 patient-years is 1.2 blood stream infections per patient per 8.8 years

We have bigger fish to fry in dialysis than one BSI per decade.

Survival analysis

Tables with actual event rates

The oral sema results are interesting

Difficult to comment indirectly, but seems less impressive than injectable sema?

Lot of kidney and HF events and favourable point estimates but not a huge effect

#ACC25

Although I suppose that the newly published meta-analysis is the counterpoint.

Starter packs may be passé - but we have had an influx, and we now have a 1/3rd full 6th nephrology pack

5th pack go.bsky.app/JJ4h8su
4th pack: go.bsky.app/YeuH82
3rd pack: go.bsky.app/2yLiYN4
2nd pack go.bsky.app/N27Kzri
1st pack: go.bsky.app/H4td28C
6th go.bsky.app/Gsm6BeJ

#NephSky

Also note two large RCTs ongoing - or about to start - in France: bsky.app/profile/dgue...

INCH-HD - Australasian Kidney Trials Network (AKTN) The INCremental dialysis to improve Health outcomes in people starting Haemodialysis (INCH-HD) study: a randomised controlled trial

We also recently transitioned a pt to both - incremental HDF 💧💦 Some are very CONVINCEd in our dept but we may INCH closer to finding an answer #AKTN aktn.org.au/inch-hd/ pubmed.ncbi.nlm.nih.gov/36938090/ @sarahkmels.bsky.social @nephmadness.bsky.social

#Quiz: A man in his 40s with untreated hypertension presented with right-sided neurologic deficits and slurred speech. His hypertension & age prompted investigation for a secondary etiology of his hypertension. What is the differential diagnosis?

bit.ly/3gyO2ie (FREE)

Ugh
This is a nephrologist
(And an NSMC internship grad)

#NephSky #MedSky

>50% of Nephrologists in the US are foreign graduates, likely many not US citizens. It's one of most cognitively complicated specialties in medicine, and not paid well enough for amount of work involved for many US grads. Good luck caring for aging US population when deporting >50% of your doctors

#NephSky #MedSky
We support our Nephrology colleagues everywhere!
This is not acceptable, free Dr. Alawieh.

4-year-old Wisconsin boy calls 911 after mom ate his ice cream | CNN A 4-year-old boy in Wisconsin called 911 last week to report a very serious offence: his mother ate his ice cream.

There are some things in life you just don’t do - like steal someone’s ice cream.

Obinutuzumab in lupus nephritis: The REGENCY Trial Visual Abstract — NephJC Is Obinutuzumab Effective and Safe in Active Lupus Nephritis?  Check out the beautiful VA by NSMC Faculty Dr Divya Bajpai on the REGENCY Trial, answering the same.

It's March, 2 days before #WorldKidneyDay, so tonight there is the perfect opportunity to celebrate ( 9 pm Eastern, on 🦋)🌺🌻 #NephJC

🎨Until then, take a look at this beautiful and colorful #visualabstract made by Divya Bajpai

www.nephjc.com/news/2025/3/...