Varjosalo_Lab

A photo of a Nobel medal

BREAKING: The Nobel Prize in Physiology or Medicine has been awarded jointly to Mary E. Brunkow, Fred Ramsdell, and Shimon Sakaguchi "for their discoveries concerning peripheral immune tolerance"

Stay tuned for more.
#NobelPrize

Awesome to see GlyCounter at work!

www.biorxiv.org/content/10.1...

Final countdown! Only 3 days to go until the YPIC Webinar #19: Transition from Academia to Start-Up.

#YPIC #Proteomics #StartUpScience #ScienceCareers #AcademicToIndustry

State-of-the-Art and Future Directions in Structural Proteomics Structural proteomics has undergone a profound transformation, driven by the convergence of advanced experimental methodologies and computational innovations. Cutting-edge mass spectrometry (MS)-based...

New review w/ Lotta J. Happonen (MCP): “State-of-the-Art and Future Directions in Structural Proteomics.” Integrating XL-MS/HDX-MS/LiP-MS with cryo-EM, NMR, X-ray, SAXS/SANS, native & top-down MS + AI.
Full text: www.mcponline.org/article/S153...

Thrilled to share: Helsinki Proteomics Center is installing 3 Thermo Scientific Orbitrap Astral/Astral Zoom mass spectrometers. First Astral Zoom arrived in early Aug—among the first worldwide. Rollout by end of summer 2025. Read more: lnkd.in/d76vpMf6 #proteomics #massspectrometry

The pivot penalty in research - Nature An analysis of millions of scientific papers and patents reveals a ‘pivot penalty’ when researchers shift direction, with the impact of studies decreasing rapidly the further they move from their prev...

www.nature.com/articles/s41... 🧪

1️⃣ 🇿🇦🏴‍☠️ spotted!

Cool pic! Can you Photoshop you holding a helm?

Regional emperor penguin population declines exceed modelled projections - Communications Earth & Environment The number of emperor penguins in the Bellingshausen and Weddell Sea declined by 22% over the period 2009–2023, a reduction of 1.6% per year, exceeding predictions from population models based on high...

🐧📉 Emperor penguin decline worse than predicted

A new study finds a 22% drop in emperor penguins (2020–2023) in part of Antarctica – far steeper than climate models expected.

This highlights urgent risks from sea ice loss

🔗 www.nature.com/articles/s43...

#SciComm #ClimateChange #Penguins 🧪

Works for me 🤔

Luke Brzozowski of ‪@uhn.ca showed how 20+ core facilities are driving hospital-based innovation at #CTLS2025, from genomics to theranostics.

💡 Techna team
🧪 Biobanks & imaging
🏥 Research meets care

#CTLSBrno #CoreFacilities #TranslationalResearch #Stratocore @ctlslifescience.bsky.social

Back from ASMS 2025 — what a ride!
Tech 💥 Science 🧬 Pirates 🏴‍☠️ Crabs 🦀 and great conversations with old and new friends.
Grateful for the laughs, the inspiration, and the community.
Already missing Baltimore a bit.

See you next year at ASMS in San Diego! 🌞🌊

#ASMS2025 #massspec #blueskyscience

TopCysteineDB: A Cysteinome-wide Database Integrating Structural and Chemoproteomics Data for Cysteine Ligandability Prediction Development of targeted covalent inhibitors and covalent ligand-first approaches have emerged as a powerful strategy in drug design, with cysteines be…

A potentially very useful tool to assess Cys ligandability on proteins
www.sciencedirect.com/science/arti...

Feels like 1/3 less than last year. And maybe also add location to the list? My bet is that San Diego will be HUGE.

Well, there is some turbulence...

DIA-NN 2.2.0 is released! The new DIA-NN 2.2.0 Enterprise achieves up to ~1.6x median speedup on 64-cores under Windows (please see benchmark below). Release notes: github.com/vdemichev/Di..., download (Academia): github.com/vdemichev/Di...

This year’s #ASMS2025 is already off to an unexpected start. Helsinki-Vantaa airport on strike (again).
Luckily, I am ✈️ Icelandair—thanks to @evosep.bsky.social for scheduling me for Saturday🙏

Let’s see how this adventure unfolds. Wish me luck—and hope to see many of you in Baltimore!

Cannot agree more 😄
And also some additional pics/video of robots ☝️

Sequencing?

MultiStageSearch: An Iterative Workflow for Unbiased Taxonomic Analysis of Pathogens Using Proteogenomics pubs.acs.org/doi/10....

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#proteomics #prot-paper

Nothing is too obscure for me 💪

Are you referring to Diva Plavalaguna?

Data-driven extraction of human kinase-substrate relationships from omics datasets Phosphorylation forms an important part of the signalling system that cells use for decision making and regulation of processes such as cell division …

We present SELPHI 2.0 a machine learning model integrating >40 sequence, omics and structural features to predict kinase-substrate interactions between 420 kinases and 240K phosphosites and improve interpretation of global phosphoproteomics data www.sciencedirect.com/science/arti...

Blog post I Automated Plasma Proteomics from Sample to Evotip New study shows how combining the Evosep One with automated Evotip sample preparation enables scalable, high-throughput plasma proteomics.

University of Helsinki have developed a fully automated #plasma #proteomics workflow—from sample prep to Evotip loading. Achieving >4,200 proteins/sample with high reproducibility and low cost, this workflow is a game-changer for large-scale clinical studies.

Happy that our article is Editor´s choice in the May issue of 2025 in @jphysiol.bsky.social.

physoc.onlinelibrary.wiley.com/doi/10.1113/...

You guys have also summer?! 🤔🤯

Heading to #ASMS2025 in Baltimore? Join us May 31 for the Evosep User Meeting! Markku Varjosalo shares insights on automated plasma workflows.
Connect, learn, and network—refreshments included!
Register here: www.evosep.com/asms2025/
#teammassspec #proteomics #lcms

Automated MagNet Enrichment Unlocks Deep and Cost-Effective LC-MS Plasma Proteomics www.biorxiv.org/cont...

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#proteomics #prot-preprint

Happy to host good candidates!
DM for more info.