Abdulmunaim Eid

Riding back to Honolulu airport after attending & presenting at the #MDSCongress. Charles, the Lyft driver, has a theme for every 2 months of the year. This is Oct-Nov Halloween Mario theme. He also takes it upon himself to teach passengers something about Hawaii. Great conference & great Lyft ride!

#MDSCongress

It was a much less organic experience than it should be. I don't know if this choice was the convention center's or the MDS, but either way I think if you do a survey, the majority would prefer the traditional poster experience. Amazing conference nevertheless! 3/3

The electronic format limits/virtually eliminates the interaction between the presenters and those who are viewing the posters which is essential for the networking aspect and also for the scientific discussion of the material. Also, the sound on the phone was often delayed and cutting off. 2/3

Great sessions in @movedisorder.bsky.social congress in #Honolulu with outstanding speakers and excellent organization. I must say, however, that the poster session is a disaster. The traditional way works much better. 1/3

I think a clear question, solid methods & solid argument advance science most regardless of the story completeness. What is harming science is pushing scientists to publish frequently or in high IF journals leading to "manipulating/inflating" the question, methods, and argument, and hiding truth.

To my knowledge, there was no discussion or mention to cognitive impairment or dementia in the context of gabapentin/pregabalin in the recent RLS guidelines. I think this is something I'm going to discuss with patients going forward. 5/5

Nevertheless, this is an important study that makes us think about chronic gabapentin use. In restless leg syndrome, for example, recent guidelines bumped gabapentin & pregabalin up to the first-line treatment spot because of augmentation & other side effects associated with dopamine agonists. 4/5

Given this and the inflammation and hemodynamic and biochemical changes associated with surgery and anesthesia, it is plausible that surgery in younger patients is also a risk for cognitive decline later in life. Thus, I would have loved to see surgery included in the propensity matching. 3/5

The authors include multiple categories of medications and chronic diseases known to contribute to dementia risk, but not surgery which we know from studies and clinical practice that it increases the risk for delirium and long-term cognitive decline in the elderly. 2/5

Risk of dementia following gabapentin prescription in chronic low back pain patients Introduction Gabapentin is widely used to treat chronic pain, but its association with cognitive decline and dementia remains unclear. This study examined whether gabapentin prescription is associated...

This is an important study that agrees with previous reports suggesting gabapentin & pregabalin use as a risk factor for cognitive impairment and dementia. My only major concern is that spinal and orthopedic surgery or surgery in general was not used in the propensity score matching procedure. 1/5

The FDA Has Ended Required Blood Monitoring for Clozapine Use—Will This Impact the Management of Parkinson's Disease Psychosis? Click on the article title to read more.

A balanced and well-researched article on clozapine for Parkinson disease psychosis in light of the new FDA removal of required blood count monitoring.

doi.org/10.1002/mds....

Amazing work led by our collaborator and brilliant PhD student Jake Chernicky.

I just signed the open letter in support of the Bethesda Declaration

Great!

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Do you recommend it as an add-on to preventives? And, how much do you typically recommend?

Update on the Treatment of Autonomic Disorders - Current Treatment Options in Neurology Purposeof Review Autonomic disorders disrupt homeostasis and cause symptoms such as orthostatic hypotension, urinary urgency, bladder overfilling, sexual dysfunction, constipation, and gastroparesis. ...

Our review 'Update on the Treatment of Autonomic Disorders' just got published. We discuss non-pharmacological, pharmacological, and neuromodulatory and device options for autonomic disorders in a very clinic-oriented way. This is an important topic for neurologists and primary care physicians.

Why academia is sleepwalking into self-destruction. My editorial @brain1878.bsky.social If you agree with the sentiments please repost. It's important for all our sakes to stop the madness
academic.oup.com/brain/articl...

Mind-blowing case of the day. This guy w/ Parkinson's has a left leg amputation. Later he develops phantom dystonia in the region of the missing limb? Eid, Rodrigo, and Norris teach us about the phenomenon through a case they published in the Movement Disorders Clinical Practice Journal.

Parkinson Disease‐Related Phantom Dystonia in an Amputated Limb Click on the article title to read more.

Our report on PD-Related Phantom Dystonia in an Amputated Limb just got published in @mdcp-journal.bsky.social. Fascinating phenomenon; to my knowledge, never been reported before though other reported phenomena e.g. virtual dystonia are possibly related.
PDF: onlinelibrary.wiley.com/share/author...

Great guidance for caregivers; particularly applicable to Alzheimer disease

Are we paying too much for biomedical research? Trump's attack on NIH

Excellent article! I particularly like the last paragraph.

In my opinion, these aspects should be left to society to organize (NOT to corporations OR governments). Of course, a sort of supervisory power exercised by the government is always needed, but that should be kept to a minimum. 2/2

Like most, I’m worried about the course of action the new US administration is taking towards scientific activity and healthcare. However, I don’t think the appropriate long-term response is to ensure administrations take a different course in the future. 1/2

The reduced striatal & normal cortical metabolism (FDG PET) make neurodegenerative diseases much less likely and the negative Aβ PET virtually excludes Alzheimer disease in particular, thus pointing to the effect of isolated vascular changes in the basal ganglia on cognition.

État Criblé | Neurology

Led by Dr. Erika Weil, we publish a report in Neurology highlighting a patient with striatal ePVSs (beautifully captured on 7T MRI) likely responsible for her impaired executive function as suggested by reduced striatal & normal cortical metabolism (FDG PET) and neg Aβ PET.
doi.org/10.1212/WNL....

Long somatic DNA-repeat expansion drives neurodegeneration in Huntington’s disease Single-cell measurement of the Huntington’s disease-causing CAG repeat reveals that somatic expansion of this repeat drives pathological changes in neurons, providing insights into disease progression...

A very interesting article showing how the unstable HD alleles cause striatal projection neuronal degeneration by the process of somatic CAG repeat expansion beyond 150 repeats.

www.cell.com/cell/fulltex...

🚨Interested in Dystonia?🚨
@braincircuits.bsky.social

GPi DBS for dystonia is effective.

More recently, STN DBS has been investigated, as an alternative.

In what enfolded like a stunning thriller to me, Konstantin Butenko tells a tale of two networks…

www.pnas.org/doi/10.1073/...