Tiffany Pang

We're #hiring a #postdoc to join our lab 🧪 in Melbourne 🇦🇺🦘 in #StemCell and #Cancer #Epigenetics. Great opportunity to lead a research project within the broader vision of the lab, with plenty of scope to develop as an independent leader 👩‍🔬🔬

Apply by 27 Feb

careers.petermac.org/job/MELBOURN...

Happy Chinese New Year/lunar new year to all celebrating! Here is our Malaysian tradition of low sang salad to usher in a great 2025!

Oh wow...

Congrats Fer!

High-throughput Kinetics using capillary Electrophoresis and Robotics (HiKER) platform used to study T7, T3, and Sp6 RNA polymerase misincorporation T7 RNA Polymerase (RNAP) is a widely used enzyme with recent applications in the production of RNA vaccines. For over 50 years denaturing sequencing gels have been used as key analysis tools for probi...

pmc.ncbi.nlm.nih.gov/articles/PMC...

As our ability to make new proteins in a high throughput manner increases, there is a need to create a platform that allows for rapid characterization of these proteins.
NEB recently published our HIKER platform (on Opentrons OT-2) to showcase 1500 time pts of misincorporations of our polymerases.

The # of states in the USDA milk testing program(H5N1)⬆️. Improve testing & iiMS-PCR was born:

*Indexing @ cDNA syn
*Opt annealing temps for full length/homo regions of primers.
*iiMS-PCR used for H5N1 response in Cambodia:
🐥https://shorturl.at/5blvl 🐓

A Peter Thielen (John Hopkins) & NEB collab

First bird flu death reported in the U.S., according to the CDC Health officials in Louisiana say a person there has died after catching bird flu. This marks the first reported death in the U.S. from the virus during the current outbreak.

Health officials in Louisiana say a person there has died after catching bird flu. This marks the first reported death in the U.S. from the virus during the current outbreak.

DNA reveals secrets of Australia's elusive marsupial mole Researchers have probed the genetics of one of Australia's most elusory animals, the marsupial mole.

Researchers have probed the genetics of one of Australia's most elusory animals, the marsupial mole.

Kia Ora from Takaka!

Email away message activated! Spending Christmas back in Christchurch. See you all in 2025!

Do you need us to send you some tim tam for your drawer?!

As we rush around towards the 2024 work finish line before the holidays, here's your blood donation reminder.
We are in need of all types, so please consider donating. Centres normally see a drop off in donations due to the chaotic festive season.

The discovery of 5mC-selective deaminases and their application to ultra-sensitive direct sequencing of methylated sites at base resolution. Mining phages for new enzymatic activities continues to be important for the development of new tools for biotechnology. In this study, we used MetaGPA—a method linking genotype to phenotype in metage...

Bacteriophages never stop giving: a new enzyme used in human methylome analysis (discovered from Metagenomics from bacteriophages found in sewage)

Congrats James!

Jenny Molloy from University of Cambridge talks about the significant disparity for African countries to advance in scientific research. Factors such as access to reagents, cost burden of cold chain logistics, lack of manufacturing capabilities severely slows down progress.

Ekkkk! Free science tattoos from the Centre of Excellence Syn Bio conference !

Decoding m6Am by simultaneous transcription-start mapping and methylation quantification N [6][1],2’- O -dimethyladenosine (m6Am) is a modified nucleotide located at the first transcribed position in mRNA and snRNA that is essential for diverse physiological processes. m6Am mapping method...

Jaffrey lab's recent publication on CROWN-seq which allows for identification of transcription start nucleotides and quantifies m6Am modification.
m6Am modification has diverse cellular context but effect of m6Am on mRNA is hugely unclear.

www.biorxiv.org/content/10.1...

My mum took me to see Grave of the Fireflies when I was 7. It left me traumatized. It was animation but the storyline was for adults!

This is a tough one. For me, I have sentimental ties with real trees as this is what we got every year in the states. For me, its all sensory: picking the tree in a cold parking lot, strapping it to our car, windows down and holding on tight to the rope, the smell of pine etc.

Sometimes getting an idea across with words can be difficult. Mark Dawson @mafdawson.bsky.social used this simple but effective image to get the EMBO students thinking about the definition of Epigenetics.

Story telling is so important in science.

Cream cheese in sushi was so popular in the states! I haven't really seen it take hold here in Australia

Hey Hamish, I totally agree about the lack of funding available to basic research, the lifeline of scientific discovery and advancement. Congrats on your new role at Proxima. I just had a chat with Amanda today!

Seven-year performance of a clinical metagenomic next-generation sequencing test for diagnosis of central nervous system infections - Nature Medicine Next-generation metagenomic testing increases the accuracy and sensitivity of the etiology of central nervous system infections in hospitalized patients.

Australia's META GP program has made strides in developing their own pipelines in each different nodes. This recent Charles Chiu paper highlights their clinical metagenomics NGS results for over 1100 patient samples & their diagnosis. A possible look into our future:
www.nature.com/articles/s41...

When we come together, we can do great things!
Afrigen's main goal is to close the gap on vaccine inequality by manufacturing mRNA vaccines for low income countries. This is achieved by partnerships w/ different entities like mRNA Victoria, New England Biolabs & many more.

tinyurl.com/fhxxxmdw

Sunday dinner because we can't make it to Malaysia this year

Oh this I love

Did you get stretchy business suit pants?

What, where did you get this and what will you do with it

My first blue sky post is about what I saw on X.... My eyes so tuned to science , I thought Ruggable ad was a PCR post first thing in the morning...